Mechanisms involved in the promoting activity of fibroblasts in HTLV-1-mediated lymphomagenesis: Insights into the plasticity of lymphomatous cells

Among the mechanisms leading to progression to Adult T-cell Leukaemia/Lymphoma in Human T-cell Leukaemia Virus type 1 (HTLV-1)-infected subjects, the contribution of stromal components remains poorly understood. To dissect the role of fibroblasts in HTLV-1-mediated lymphomagenesis, transcriptome studies, cytofluorimetric and qRT-PCR analyses of surface and intracellular markers linked to plasticity and stemness in coculture, and in vivo experiments were performed. A transcriptomic comparison between a more lymphomagenic (C91/III) and the parental (C91/PL) cell line evidenced hyperactivation of the PI3K/Akt pathway, confirmed by phospho-ELISA and 2-DE and WB analyses. C91/III cells also showed higher expression of mesenchymal and stemness genes. Short-term coculture with human foreskin fibroblasts (HFF) induced these features in C91/PL cells, and significantly increased not only the cancer stem cells (CSCs)-supporting CD10+GPR77+ HFF subpopulation, but also the percentage of ALDH1bright C91/PL cells. A non-cytotoxic acetylsalicylic acid treatment decreased HFF-induced ALDH1bright C91/PL cells, downregulated mesenchymal and stemness genes in cocultured cells, and delayed lymphoma growth in immunosuppressed mice, thus hindering the supportive activity of HFF on CSCs. These data suggest that crosstalk with HFF significantly intensifies the aggressiveness and plasticity of C91/PL cells, leading to the enrichment in lymphoma-initiating cells. Additional research is needed to better characterize these preliminary findings

Agroecologia e justiça ambiental: um diálogo possível

O movimento por justiça ambiental surgiu nos EUA na década de 1970 quando pesquisas revelaram que os resíduos tóxicos eram destinados de forma desproporcional à populações afrodescendentes. A agroecologia, campo de produção científico interdisciplinar, também se consolidou na década de 1970, oriunda da fusão das ciências naturais e sociais, com o propósito de permitir o estilos de agricultura com maiores níveis de sustentabilidade, socialmente justa e economicamente viável. Esse trabalho situa-se no campo da pesquisa teórica, de caráter exploratório sobre as concepções e convergências da área da justiça ambiental e da agroecologia, utilizando-se de uma pesquisa bibliográfica com abordagem qualitativa. Ao fortalecer os modos de vida camponeses, a agroecologia tem contribuído na luta por justiça ambiental. Nesse sentido, podemos perceber a relação entre o movimento agroecológico e o movimento por justiça ambiental, dada suas convergências no objetivo de promover a justiça social.The movement for environmental justice emerged in the US in the 1970s when research revealed that toxic waste was allocated proportional to the Afro-descendant populations. Agroecology, interdisciplinary scientific production field, also consolidated in the 1970s, derived from the fusion of natural and social sciences, in order to allow the farming styles with higher levels of sustainability, socially just and economically viable. This work lies in the field of theoretical research, exploratory on the concepts and similarities of the area of environmental justice and agroecology, using a literature research with qualitative approach. By strengthening livelihoods farmers, agroecology has contributed in the struggle for environmental justice. In this sense, we can see the relationship between agro-ecological movement and the movement for environmental justice, given their convergence in order to promote social justice.Eje A6: Desarrollo Rural, Movimientos Sociales, Estado y AgroecologíaFacultad de Ciencias Agrarias y Forestale

Agroecologia e justiça ambiental: um diálogo possível

O movimento por justiça ambiental surgiu nos EUA na década de 1970 quando pesquisas revelaram que os resíduos tóxicos eram destinados de forma desproporcional à populações afrodescendentes. A agroecologia, campo de produção científico interdisciplinar, também se consolidou na década de 1970, oriunda da fusão das ciências naturais e sociais, com o propósito de permitir o estilos de agricultura com maiores níveis de sustentabilidade, socialmente justa e economicamente viável. Esse trabalho situa-se no campo da pesquisa teórica, de caráter exploratório sobre as concepções e convergências da área da justiça ambiental e da agroecologia, utilizando-se de uma pesquisa bibliográfica com abordagem qualitativa. Ao fortalecer os modos de vida camponeses, a agroecologia tem contribuído na luta por justiça ambiental. Nesse sentido, podemos perceber a relação entre o movimento agroecológico e o movimento por justiça ambiental, dada suas convergências no objetivo de promover a justiça social.The movement for environmental justice emerged in the US in the 1970s when research revealed that toxic waste was allocated proportional to the Afro-descendant populations. Agroecology, interdisciplinary scientific production field, also consolidated in the 1970s, derived from the fusion of natural and social sciences, in order to allow the farming styles with higher levels of sustainability, socially just and economically viable. This work lies in the field of theoretical research, exploratory on the concepts and similarities of the area of environmental justice and agroecology, using a literature research with qualitative approach. By strengthening livelihoods farmers, agroecology has contributed in the struggle for environmental justice. In this sense, we can see the relationship between agro-ecological movement and the movement for environmental justice, given their convergence in order to promote social justice.Eje A6: Desarrollo Rural, Movimientos Sociales, Estado y AgroecologíaFacultad de Ciencias Agrarias y Forestale

Saúde, ambiente e sustentabilidade.

Colaboradores: Ada Cristina Pontes Aguiar; Guilherme Costa Delgado; Horácio Martins de Carvalho; Lucas Resende; Marcelo Firpo de Souza Porto; Núcleo Tramas; Pedro Costa Cavalcanti de Albuquerque; Vanira Matos Pessoa; Veruska Prado Alexandre; Vicente Eduardo Soares de Almeida, CNPH