41 research outputs found
A Dual Model of Open Source License Growth
Every open source project needs to decide on an open source license. This
decision is of high economic relevance: Just which license is the best one to
help the project grow and attract a community? The most common question is:
Should the project choose a restrictive (reciprocal) license or a more
permissive one? As an important step towards answering this question, this
paper analyses actual license choice and correlated project growth from ten
years of open source projects. It provides closed analytical models and finds
that around 2001 a reversal in license choice occurred from restrictive towards
permissive licenses.Comment: 14 pages, 6 figure
Absolute frequency measurement of the magnesium intercombination transition
We report on a frequency measurement of the clock
transition of Mg on a thermal atomic beam. The intercombination
transition has been referenced to a portable primary Cs frequency standard with
the help of a femtosecond fiber laser frequency comb. The achieved uncertainty
is which corresponds to an increase in accuracy of six
orders of magnitude compared to previous results. The measured frequency value
permits the calculation of several other optical transitions from to
the -level system for Mg, Mg and Mg. We describe in
detail the components of our optical frequency standard like the stabilized
spectroscopy laser, the atomic beam apparatus used for Ramsey-Bord\'e
interferometry and the frequency comb generator and discuss the uncertainty
contributions to our measurement including the first and second order Doppler
effect. An upper limit of in one second for the short term
instability of our optical frequency standard was determined by comparison with
a GPS disciplined quartz oscillator.Comment: 8 pages, 8 figure
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10−5. We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10−17; including ADGC data, meta P = 5.0 × 10−21) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10−14; including ADGC data, meta P = 1.2 × 10−16) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10−4; including ADGC data, meta P = 8.6 × 10−9), CD33 (GERAD+, P = 2.2 × 10−4; including ADGC data, meta P = 1.6 × 10−9) and EPHA1 (GERAD+, P = 3.4 × 10−4; including ADGC data, meta P = 6.0 × 10−10)