An investigation of the relationship between characteristics of self-actualization and of job satisfaction of selected faculty in higher education

Does a relationship exist between characteristics of self-actualization and of job satisfaction of selected business faculty in higher education? Do these characteristics differ significantly when analyzed by independent variables: faculty rank, sex, age, degree (highest earned), salary, years (number teaching at present institution), total (years teaching in higher education), and business (number of years experience)? This study was an attempt to answer these questions;Faculty self-actualization was measured by the Personal Orientation Inventory (POI). The POI is a 150-item, two-choice comparative value and behavior judgments instrument. Faculty job satisfaction was measured by the Minnesota Satisfaction Questionnaire (MSQ) long form, consisting of 100 items. Subjects selected a single response per questionnaire item among five responses that were available in a Likert-type format, the response range being very dissatisfied, dissatisfied, neither, satisfied, or very satisfied. A Faculty Data Sheet was developed by the investigator to collect the necessary independent variable data;Survey packets, which included a cover letter, POI, MSQ, and Faculty Data Sheet, were distributed to 108 business faculty members at the University of Iowa, 42 business faculty at Drake University, and 52 to business faculty at the Des Moines Area Community College. A total of 53 valid survey packets (POI, MSQ, and Faculty Data Sheet) were returned;The Statistical Package for Social Sciences X (SPSS(\u27x)), Computer Center of Iowa State University, was used for the analysis of the data. Subprograms Pearson CORR., t-test, one-way analysis of variance, and Scheffe and Duncan tests were used in the analysis. The alpha level of .05 was used to determine significant differences;Two null hypotheses were tested in this study: (1) No significant relationships exist among the scores on the 12 scales of the POI and scores on the 21 scales of the MSQ. (2) No significant differences exist among independent variables and scores on the 12 scales of the POI and scores on the 21 scales of the MSQ;As a result of the analysis of data, null Hypothesis 1 was not rejected and null Hypothesis 2 was rejected. A key finding of this study was the impact that the level of business experience had on a large number of MSQ scales

Methodology for evaluating vehicle fatigue life and durability

Vehicle durability, which defines the useful life of a vehicle, is a high priority for some consumers. Life consumption monitoring can be used to determine fatigue damage by directly or indirectly monitoring the loads placed on critical vehicle components that are susceptible to failure from fatigue damage. By monitoring vehicle life consumption, the Army can predict mechanical failures before they occur and determine the useful life of vehicles. The example vehicle used for this study is the Ml 101 High Mobility Trailer (HMT) that is normally towed behind a High Mobility Multi-purpose Wheeled Vehicle (HMMWV). As originally designed, the HMT experiences a fatigue failure of the drawbar. For this analysis, experimental data was taken from a HMT traveling over known test courses. The data was used to validate a computer simulation, and to determine the feasibility of life consumption monitoring. Multivariate regressions and principal component analysis (PCA) were used to determine which sensors most accurately reflect the loads on the drawbar at\u27 the failure point. Regression and dynamic models were made after the proper decimation and filtering of the data was determined. The models were then used to predict the fatigue life of the trailer. The results of this study show that simulations can be modified to be representative of the vehicle being tested. The results also show that the fatigue life and durability of the vehicle can be predicted with a model and data from sensors placed on the vehicle

Transcending the status quo: a communication perspective for improving health behaviors at Eastern Washington University

There is a belief known as the \u27college experience;\u27 an experience that some understand as a right of passage. This notion continues to be passed from generation to generation; what happens without our noticing is that the demands of that \u27college experience\u27 are changing. Survey results indicate that this \u27experience\u27 continues to perpetuate, that college students have skewed perceptions of vulnerabilities and are willing to take unhealthy risks, all as part of the \u27college experience.\u27 Through a mixed methods approach, this research demonstrates that advances in remedial health education are positively affecting students \u27abilities\u27 to gain access to, understand and use information in ways which promote and maintain good health\u27\u27 (World Health Organization, as cited in Nutbeam, 2000, p.264 and Ratzan, 2000, p. 210). This research also identifies the disparity between having the \u27ability\u27 and having the \u27motivation\u27 to mitigate risk. This research further substantiates an exigent need for a holistic approach to improving health literacy, and designing health messages for improving health behaviors at Eastern Washington University --Document

The design and testing of an electromagnetic anti-lock brake system with microprocessor control

Anti-lock brake systems are used to prevent wheel lockup on most vehicles sold today. This thesis involves the design and testing of an electromagnetic antilock brake system. This system is designed as a replacement for the current anti-lock brake systems used on drum brakes. The primary difference in the two systems is the replacement of the pressure modulator that is currently used with an electromagnetic release system. The Electromagnetic release system consists of two main parts, a cam and an electromagnet.The cam is located between the lower pivot points of the brake shoes. The cam is connected to the electromagnet by a release arm. The magnet is held in close proximity to a steel plate connected to the rotating hub. When the electromagnet is energized it is attracted to the rotating steel plate. The cam is then rotated by the release arm which is connected to the electromagnet. This causes the lower points of the brake shoes to move together and release the brake, thus preventing complete wheel lockup, and tends to keep the wheel slip near the peak of the braking coefficient curve. When the deceleration has decreased to an acceptable level, the magnet is de-energized and the return spring rotate the cam which reapplies the brake. The electromagnetic release system is less expensive and simpler than the pressure modulators used in current anti-lock drum brake systems.The electromagnetic release system also has the capability to operate faster than the pressure modulators used in current anti-lock brake systems.The electromagnetic anti-lock brake system proved to work reasonably well in preventing wheel lockup and in controlling deceleration. The electromagnetic anti-lock brake system was limited by the capabilities of itk control system. The control system used for testing had a limited resolution and reduced the speed of the system.The electromagnetic anti-lock brake system has the potential for being a suitable replacement for current anti-lock drum brake systems.V

Salesperson Listening: A Replication And Extension Of The ILPS Scale

The primary purpose of this study was further testing of the ILPS scale (Castleberry, et al. 1999). The sample consisted of 101 salespeople from three business-to-business firms in the Midwest.  In addition to the ILPS exhibiting good reliability, results are consistent with prior research indicating a significant positive relationship between listening ability and salesperson performance.  Results also found a significant positive relationship between listening ability and adaptability and age.  Contrary to past salesperson listening research, females were found to be better listeners than men, and there was no significant relationship between listening and salesperson experience. Implications for managers and researchers are offered.&nbsp

Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence

<p>Abstract</p> <p>Background</p> <p>Anti-Aβ immunotherapy is a promising approach to the prevention and treatment of Alzheimer's disease (AD) currently in clinical trials. There is extensive evidence, both in mice and humans that a significant adverse event is the occurrence of microhemorrhages. Also, vasogenic edema was reported in phase 2 of a passive immunization clinical trial. In order to overcome these vascular adverse effects it is critical that we understand the mechanism(s) by which they occur.</p> <p>Methods</p> <p>We have examined the matrix metalloproteinase (MMP) protein degradation system in two previously published anti-Aβ immunotherapy studies. The first was a passive immunization study in which we examined 22 month old APPSw mice that had received anti-Aβ antibodies for 1, 2 or 3 months. The second is an active vaccination study in which we examined 16 month old APPSw/NOS2-/- mice treated with Aβ vaccination for 4 months.</p> <p>Results</p> <p>There is a significant activation of the MMP2 and MMP9 proteinase degradation systems by anti-Aβ immunotherapy, regardless of whether this is delivered through active vaccination or passive immunization. We have characterized this activation by gene expression, protein expression and zymography assessment of MMP activity.</p> <p>Conclusions</p> <p>Since the MMP2 and MMP9 systems are heavily implicated in the pathophysiology of intracerbral hemorrhage, these data may provide a potential mechanism of microhemorrhage due to immunotherapy. Increased activity of the MMP system, therefore, is likely to be a major factor in increased microhemorrhage occurrence.</p

HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

Donors of nitroxyl (HNO), the one electron-reduction product of nitric oxide (NO. ), posi-tively modulate cardiac contractility/relaxation while limiting ischemia-reperfusion (I/R) injury. The mechanisms underpinning HNO anti-ischemic effects remain poorly understood. Using isolated perfused rat hearts subjected to 30 min global ischemia/1 or 2 h reperfusion, here we tested whether, in analogy to NO., HNO protection requires PKCε translocation to mitochondria and KATP channels activation. To this end, we compared the benefits afforded by ischemic preconditioning (IPC; 3 cycles of I/R) with those eventually granted by the NO. donor, diethylamine/NO, DEA/NO, and two chemically unrelated HNO donors: Angeli’s salt (AS, a prototypic donor) and isopropyla-mine/NO (IPA/NO, a new HNO releaser). All donors were given for 19 min before I/R injury. In control I/R hearts (1 h reperfusion), infarct size (IS) measured via tetrazolium salt staining was 66 ± 5.5% of the area at risk. Both AS and IPA/NO were as effective as IPC in reducing IS [30.7 ± 2.2 (AS), 31 ± 2.9 (IPA/NO), and 31 ± 0.8 (IPC), respectively)], whereas DEA/NO was significantly less so (36.2 ± 2.6%, p < 0.001 vs. AS, IPA/NO, or IPC). IPA/NO protection was still present after 120 min of reperfusion, and the co-infusion with the PKCε inhibitor (PKCV1-2500 nM) prevented it (IS = 30 ± 0.5 vs. 61 ± 1.8% with IPA/NO alone, p < 0.01). Irrespective of the donor, HNO anti-ischemic effects were insensitive to the KATP channel inhibitor, 5-OH decanoate (5HD, 100 μM), that, in contrast, abrogated DEA/NO protection. Finally, both HNO donors markedly enhanced the mitochondrial permeability transition pore (mPTP) ROS threshold over control levels (≅35–40%), an action again insensitive to 5HD. Our study shows that HNO donors inhibit mPTP opening, thus limiting myo-cyte loss at reperfusion, a beneficial effect that requires PKCε translocation to the mitochondria but not mitochondrial K+ channels activation

N,N′-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase

The synthesis and biological evaluation of new types of N,N′-disubstituted thiourea and urea derivatives as inhibitors of both neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) are described. These compounds have been designed by reduction of the carbonyl group in the thiourea and urea kynurenamine derivatives 3 previously synthesized by our research group. The synthetic route performed to this new family also allows us to obtain the molecules 3 with less synthetic steps and higher global yield. Regarding the biological results, in general, the new derivatives 4a–q inhibit the neuronal NOS isoform better than the inducible one. Furthermore, thioureas exhibit higher inhibition than ureas for both isoenzymes. Among all the tested compounds, 4g shows significant nNOS (80.6%) and iNOS (76.6%) inhibition values without inhibiting eNOS. This molecule could be an interesting starting point for the design of new inhibitors with application in neurological disorders where both isoenzymes are implicated such as Parkinson's disease.We are very grateful to Dr. Pedro A. Sánchez-Murcia for his help. This work was partially supported by the Instituto de Salud Carlos III through grant FI11/00432 and by Ministerio de Economía y Competitividad, Instituto de Salud Carlos III (RIC RD12/0042/0011)

Thiol-Activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy

Metallonitrosyl complexes are promising as nitric oxide (NO) donors for the treatment of cardiovascular, endothelial, and pathogenic diseases, as well as cancer. Recently, the reduced form of NO– (protonated as HNO, nitroxyl, azanone, isoelectronic with O2) has also emerged as a candidate for therapeutic applications including treatment of acute heart failure and alcoholism. Here, we show that HNO is a product of the reaction of the RuII complex [Ru(bpy)2(SO3)(NO)]+ (1) with glutathione or N-acetyl-L-cysteine, using met-myoglobin and carboxy-PTIO (2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide) as trapping agents. Characteristic absorption spectroscopic profiles for HNO reactions with met-myoglobin were obtained, as well as EPR evidence from carboxy-PTIO experiments. Importantly, the product HNO counteracted NO-induced as well as hypoxia-induced stabilization of the tumor-suppressor HIF-1α in cancer cells. The functional disruption of neovascularization by HNO produced by this metallonitrosyl complex was demonstrated in an in vitro angiogenesis model. This behavior is consistent with HNO biochemistry and contrasts with NO-mediated stabilization of HIF-1α. Together, these results demonstrate for the first time thiol-dependent production of HNO by a ruthenium complex and subsequent destabilization of HIF-1α. This work suggests that the complex warrants further investigation as a promising antiangiogenesis agent for the treatment of cancer

Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy

Immunotherapy with IL-2 and anti-CD40 induces the expression of NOS2 in tumor-associated macrophages, and its expression is required for the inhibition of tumor metastasis