Long-lived selective spin echoes in dipolar solids under periodic and aperiodic pi-pulse trains

The application of Carr-Purcell-Meiboom-Gill (CPMG) $\pi-$trains for dynamically decoupling a system from its environment has been extensively studied in a variety of physical systems. When applied to dipolar solids, recent experiments have demonstrated that CPMG pulse trains can generate long-lived spin echoes. While there still remains some controversy as to the origins of these long-lived spin echoes under the CPMG sequence, there is a general agreement that pulse errors during the $\pi-$pulses are a necessary requirement. In this work, we develop a theory to describe the spin dynamics in dipolar coupled spin-1/2 system under a CPMG($\phi_{1},\phi_{2}$) pulse train, where $\phi_{1}$ and $\phi_{2}$ are the phases of the $\pi-$pulses. From our theoretical framework, the propagator for the CPMG($\phi_{1},\phi_{2}$) pulse train is equivalent to an effective ``pulsed'' spin-locking of single-quantum coherences with phase $\pm\frac{\phi_{2}-3\phi_{1}}{2}$, which generates a periodic quasiequilibrium that corresponds to the long-lived echoes. Numerical simulations, along with experiments on both magnetically dilute, random spin networks found in C$_{60}$ and C$_{70}$ and in non-dilute spin systems found in adamantane and ferrocene, were performed and confirm the predictions from the proposed theory.Comment: 25 pages, 12 figures, submitted to Physical Review

Making sense of the evolving nature of depression narratives and their inherent conflicts

Originally a psychiatric diagnosis fashioned by Western psychiatry in the 20th Century, depression evolved to encompass varying lineages of discourse and care. This article elucidates some of the current challenges – as well as emerging discourses – influencing the category of depression. Depression-like experiences are shaped by (at times conflicting) subjectivities, claims to knowledge, material realities, social contexts and access to resources. With no unified understanding of the category of ‘depression’ available, lay people, social and neuro scientists, GPs, psychiatrists, talking therapists and pharmaceutical companies all attempt to shape narratives of depression. The current paper focuses on patient narratives about depression – in the context of these wider debates – to better elucidate the ways in which depression discourses are publically developing along varying lines. In conclusion, the paper suggests that we could better conceptualise the resulting ‘depression(s)’ with concepts such as ‘society of mind’ and notions of subjectivity unbounded by individuals

In one’s own time: Contesting the temporality and linearity of bereavement

This article explores the experience and meaning of time from the perspective of caregivers who have recently been bereaved following the death of a family member. The study is situated within the broader cultural tendency to understand bereavement within the logic of stages, including the perception of bereavement as a somewhat predictable and certainly time-delimited ascent from a nadir in death to a ‘new normal’ once loss is accepted. Drawing on qualitative data from interviews with 15 bereaved family caregivers we challenge bereavement as a linear, temporally bound process, examining the multiple ways bereavement is experienced and how it variously resists ideas about the timeliness, desirability and even possibility of ‘recovery’. We posit, on the basis of these accounts, that the lived experience of bereavement offers considerable challenges to normative understandings of the social ties between the living and the dead and requires a broader reconceptualization of bereavement as an enduring affective state

The behaviours that dementia care home staff in South Africa find challenging:An exploratory study

Background: Behavioural and psychological symptoms of dementia are often the reasons for moving to a care home. Care staff, often with limited dementia training, may have to support residents with distressed behaviour on a daily basis. Evidence about the support of residents with distressed or challenging behaviour in the South African context is lacking. This exploratory study aimed to gain an understanding of what care home staff perceived to be distressed behaviour, their coping strategies and how they learned to work with residents with behavioural symptoms of dementia. Methods: An exploratory study was conducted among 17 participants working in four care homes in the Western Cape province of South Africa in 2014. Semi-structured interviews were audio-recorded. Data were analysed thematically. Findings: Findings reflected the literature with regard to examples of behavioural symptoms of people with dementia that staff find challenging to manage. Overall, the majority of staff reported holding positive feelings about working with people with dementia. All preferred interpersonal approaches to manage distressed behaviour above medication although a small minority noted the use of medication in some cases. Dementia training was considered by most participants as an unmet need. Conclusion: This exploratory study identified care home workers’ desires for training about dementia and their preferences for interpersonal as opposed to pharmacological approaches to managing residents’ distressed behaviour. The legacy of race and cultural perspectives in South Africa appears to still influence care practice and provision. Staff commitment, their interest in advancing their practice and their aspirations to offer more person-centred care were evident. Dementia training was identified as potentially helpful to care home staff who manage residents’ distressed behaviour. Training should be developed in South Africa to promote good practice

A 13CO and C18O Survey of the Molecular Gas Around Young Stellar Clusters Within 1kpc of the Sun

As the first step of a multi-wavelength investigation into the relationship between young stellar clusters and their environment we present fully-sampled maps in the J=1--0 lines of 13CO and C18O and the J=2--1 line of C18O for a selected group of thirty young stellar groups and clusters within 1kpc of the Sun. This is the first systematic survey of these regions to date. The clusters range in size from several stars to a few hundred stars. Thirty fields ranging in size from 8'x 8' to 60'x 30' were mapped with 47'' resolution simultaneously in the J=1-0 lines with Five College Radio Observatory. Seventeen sources were mapped over fields ranging in size from 3'x 3' to 13'x 13' in the J=2--1 line with 35'' resolution with the Heinrich Hertz Telescope. We compare the cloud properties derived from each of the three tracers in order to better understand systematic uncertainties in determing masses and linewidths. Cloud masses are determined independently using the 13CO and C18O transitions, these masses range from 30 to 4000 M_sun. Finally, we present a simple morphological classification scheme which may serve as a rough indicator of cloud evolution.Comment: 52 pages, 29 figures. Accepted for publication in AJ. Some figures have been reduced in resolution, a full resolution version is available from http://daisy.astro.umass.edu/~naomi/pubs/pubs.htm

Ethical issues, research and vulnerability : gaining the views of children and young people in residential care

Children and young people in residential care are some of the most vulnerable in our society. They may have experienced violence and physical, sexual or emotional abuse. They may be involved in offending or the misuse of drugs and alcohol. They are separated from their families and have to cope with living in a group situation with other young people and staff members. Children and young people in residential care also possess strengths, competencies and resilience. We have much to learn from their experiences and perspectives, both generally and surrounding their time in care. This paper will address the ethical issues which arise from gaining the views of children and young people in residential care, drawing on the experience of carrying out three studies in particular (Kendrick et al. 2004, The development of a residential unit working with sexually aggressive young men. In: H.G. Eriksson and T. Tjelflaat, eds. Residential care: horizons for the new century. Aldershot: Ashgate, 38-55; Docherty et al. 2006, Designing with care: interior design and residential child care. Farm7 and SIRCC. http://www.sircc.strath.ac.uk/publications/Designing_with_Care.pdf; Steckley, L. and Kendrick, A., 2005. Physical restraint in residential child care: the experiences of young people and residential workers. Childhoods 2005: Children and Youth in Emerging and Transforming Societies, University of Oslo, Norway, 29 June-3 July 2005, Steckley and Kendrick 2007, Young people's experiences of physical restraint in residential care: subtlety and complexity in policy and practice. In: M. Nunno, L. Bullard and D. Day, eds. For our own safety: examining the safety of high-risk interventions for children and young people. Washington, DC: Child Welfare League of America, forthcoming). The paper will discuss: information, consent and choice about involvement in the research; confidentiality, privacy and safety. It will also explore some of the more complex issues of ethical good practice which arise from researching children in their own living space. The negotiation of children's time and space must be approached carefully, with consideration of their rights and wishes. Sensitivity to children and young people's priorities and preoccupations must be paramount

The Gaia-ESO Survey: Dynamical analysis of the L1688 region in Ophiuchus

The Gaia ESO Public Spectroscopic Survey (GES) is providing the astronomical community with high-precision measurements of many stellar parameters including radial velocities (RVs) of stars belonging to several young clusters and star-forming regions. One of the main goals of the young cluster observations is to study their dynamical evolution and provide insight into their future, revealing whether they will eventually disperse to populate the field rather than evolve into bound open clusters. In this paper we report the analysis of the dynamical state of L1688 in the ρ Ophiuchi molecular cloud using the dataset provided by the GES consortium. We performed the membership selection of the more than 300 objects observed. Using the presence of the lithium absorption and the location in the Hertzspung-Russell diagram, we identify 45 already known members and two new association members. We provide accurate RVs for all 47 confirmed members. A dynamical analysis, after accounting for unresolved binaries and errors, shows that the stellar surface population of L1688 has a velocity dispersion σ ~ 1.14 ± 0.35 km s-1 that is consistent with being in virial equilibrium and is bound with a ~80% probability. We also find a velocity gradient in the stellar surface population of ~1.0 km s-1 pc-1 in the northwest-southeast direction, which is consistent with that found for the pre-stellar dense cores, and we discuss the possibility of sequential and triggered star formation in L1688

COVID-19: Rapid antigen detection for SARS-CoV-2 by lateral flow assay: A national systematic evaluation of sensitivity and specificity for mass-testing

Background Lateral flow device (LFD) viral antigen immunoassays have been developed around the world as diagnostic tests for SARS-CoV-2 infection. They have been proposed to deliver an infrastructure-light, cost-economical solution giving results within half an hour. Methods LFDs were initially reviewed by a Department of Health and Social Care team, part of the UK government, from which 64 were selected for further evaluation from 1st August to 15th December 2020. Standardised laboratory evaluations, and for those that met the published criteria, field testing in the Falcon-C19 research study and UK pilots were performed (UK COVID-19 testing centres, hospital, schools, armed forces). Findings 4/64 LFDs so far have desirable performance characteristics (orient Gene, Deepblue, Abbott and Innova SARS-CoV-2 Antigen Rapid Qualitative Test). All these LFDs have a viral antigen detection of >90% at 100,000 RNA copies/ml. 8951 Innova LFD tests were performed with a kit failure rate of 5.6% (502/8951, 95% CI: 5.1–6.1), false positive rate of 0.32% (22/6954, 95% CI: 0.20–0.48). Viral antigen detection/sensitivity across the sampling cohort when performed by laboratory scientists was 78.8% (156/198, 95% CI 72.4–84.3). Interpretation Our results suggest LFDs have promising performance characteristics for mass population testing and can be used to identify infectious positive individuals. The Innova LFD shows good viral antigen detection/sensitivity with excellent specificity, although kit failure rates and the impact of training are potential issues. These results support the expanded evaluation of LFDs, and assessment of greater access to testing on COVID-19 transmission. Funding Department of Health and Social Care. University of Oxford. Public Health England Porton Down, Manchester University NHS Foundation Trust, National Institute of Health Research