Hyper-Uricemia and Gouty Access in the Adult Population of the Southeast of Gabon: Biochemical Aspects

Gout is caused by a chronic hyperuricemia whose complications are not currently well evaluated in Africa. The aim of this study was to determine the prevalence and risk factors of hyperuricemia and gout in 85 patients recruited. A total of 26 cases of hyperuricemia, i.e., 30.6% of the study population, with 12 cases of gout and seven cases of gouty access. In this population, hyperuricemia was proportional to age (p-value < 10−4, OR = 2.6), but it was more prevalent in men, 23.5% versus 7.1% for women (p-value = 0.0047). In addition, none of these women showed signs of a gouty affection. Consumption of alcohol (OR = 13) and nucleoprotein-rich foods, obesity (BMI 30 kg/m2; OR = 6), family history of gout (OR = 6.8), as well as diseases such as high blood pressure (associated with taking diuretics; OR = 1.7), renal insufficiency (OR = 4.4) and diabetes (p < 0.049) were the main factors of the diseases associated with gout and hyperuricemia in this population. The biochemical role of these factors may increase and/or decrease the processes of synthesis and/or elimination of uric acid by acting on metabolites involved in the regulation of urate production

Bacteriological profile and antibiotic sensitivity of pus isolates in patients at Regional Hospital Center of Franceville in Gabon

Background:Bacterial resistance to antibiotics is a public health problem, it is a threat to the future. It compromises the effectiveness of antibiotic treatment and is constantly increasing worldwide. This work has been highlighted by the profile and sensitivity of pyogenic bacteria isolated at Franceville Regional Hospital Center. Methods:Effective antibiotic strategy, suppurations from the wounds of 530 patients were collected and analyzed. Biochemical identification of isolated bacterial strains was performed with Api 10s galleries and verified using Vitek-2 system. The Kirby-Bauer technic was used to perform the antibiogram. Five antibiotics were first tested in a simple way and then combined in pairs. Results:360 samples showed bacterial strains and 170 were sterile cultures. 360 microorganisms were isolated, of which 230 strains came from hospitalization surgery, 110 from minor surgery and 20 from medicine.The bacterial families identified are Enterobacteriaceae, Moraxellaceae, Pseudomonadaceae, Streptococcaceae and Xanthomonadaceae. Enterobacterizceae is the most common family with 64.69% and has revealed 7 genera Citrobacter, Enterobacter, Escherichia, Klebsiella, Serratia, Yersinia and Proteus 65% antibiotic sensitivity of simple antibiotics showed the best sensitivities with Ciprofloxacin and Ofloxacin a resistance rate 31.25%, 100% unlike Amoxicillin and Metronidazole. Ceftazidim was not very active on bacterial strains with a resistance rate of 93.75%. The interactions between antibiotics combined gave antagonistic, synergistic, indifferent and additive effects. The indifferent effect was much more observed (44 cases), in contrast to the additive effect which represented only 23 cases. The antagonic and synergistic effects were reported in 14 cases. Combined Amoxicillin and Metronidazole, Ceftazidim antibiotics showed good activity on bacterial strains, with good synergy and additive effect, or were not combined. Conclusion:The emergence of bacteria is major global problem multi-resistance. The rationalization of the prescription of antibiotics, especially Ofloxacin and Ciprofloxacin, and the optimization of bacteriological prescriptions are desirable in surgical services. However, rigor in dispensing pharmacies and the rational use of these antibiotics are essential to avoid the emergence of resistance phenomena

Phytochemical studies, antiangiogenic, anti-inflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon

Abstract Background The search for new anti-cancer molecules is one of the main concerns of oncology researchers. Scyphocephalium ochocoa is a plant of Myristicaceae family, used in traditional medicine against inflammatory diseases and several types of cancer. It is well established that free radicals, chronic inflammation and angiogenesis play an important role in initiation, tumor progression and metastasis formation. The aim of this study was to carry out a phytochemical screening, to determine the phenolic compounds content, to investigate the antiangiogenic, anti-inflammatory and antioxidant activities of water, water-ethanol and ethanol extracts of S. ochocoa. Methods Phytochemical screening and determination of phenolic compounds content were performed using standard methods. Antiangiogenic activity was assessed using chick chorioallantoic membrane (CAM) model and Drabkin test. Anti-inflammatory activity was estimated by protein denaturation and erythrocyte membrane stabilization method. Finally the antioxidant activity was appreciated by DPPH radical inhibition and phosphomolybdenum assay. Results The results of phytochemical studies show that extracts of bark of S. ochocoa are rich in polyphenols, tannins, flavonoids, proantocyanidins, saponosides, flavonols, flavanonols, sterol and triterpenes. The water extract showed good antiangiogenic activity (IC50 = 1.153 μg/mL). Strong anti-inflammatory activity was observed with all extracts, IC50 ranging from 34.775 ± 2.543 μg/mL to 74.577 ± 3.456 μg/mL for protein denaturation inhibition test and IC50 values ranging from 36.793 ± 0.529 μg/mL at 48.912 ± 0.957 μg/mL for antihemolytic activity. In addition, all extracts showed good antioxidant activity marked by a strong inhibition of the DPPH radical (IC50 ranging from 4.969 ± 0.263 μg/mL to 16.188 ± 0.336 μg/mL and AAI ranging from 3.090 ± 0.065 to 10.080 ± 0.517) and by greater total antioxidant capacity (with contents ranging from 37.654 ± 0.995 to 131.302 ± 1.102 VtCE (mg)/g dry extract). Conclusion Ultimately, these results could justify the use of S. ochocoa extracts in traditional medicine in the treatment of diseases related to angiogenesis and cancer, inflammatory diseases and diseases due to oxidative stress. A phyto-product with such a pharmacological profile could be a good candidate for the development of anticancer

Correction to: Phytochemical studies, antiangiogenic, antiinflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon

Following the publication of this article [1], the authors noticed that Figs. 1, 2 and 3 were in the incorrect order and thus had incorrect captions. The images that were incorrectly published as Figs. 1, 2 and 3 should have been published as Figs. 2, 3 and 1 respectively