The pitch-heave dynamics of transportation vehicles

The analysis and design of suspensions for vehicles of finite length using pitch-heave models is presented. Dynamic models for the finite length vehicle include the spatial distribution of the guideway input disturbance over the vehicle length, as well as both pitch and heave degrees-of-freedom. Analytical results relate the vehicle front and rear accelerations to the pitch and heave natural frequencies, which are functions of vehicle suspension geometry and mass distribution. The effects of vehicle asymmetry and suspension contact area are evaluated. Design guidelines are presented for the modification of vehicle and suspension parameters to meet alternative ride quality criteria

The disappearing women: North West ICT project final report

Project Context The Disappearing Women: Northwest ICT project was embarked upon to further understand why more women leave the sector than are being recruited, 36% of new ICT recruits in the UK (in the first quarter of 2002) were women, yet in the same period, women accounted for 46% of all leavers or ‘disappearing’ women (The DTI Women in IT Champions report 2003, Grey and Healy 2004). This continuing trend shows a decline from 27% of women making up the ICT workforce in 1997 with a drop to 21% in 2004 (The DTI Women in IT Industry report 2005b). The number of women in the ICT sector remains disappointingly small considering that women make up around 50% of the total UK workforce and significantly this figure has gradually continued to fall despite numerous initiatives to attract more women into the sector (see Griffiths and Moore 2006 for a list of high profile ‘women in ICT’ initiatives). The research team’s first gender research project - Women in IT (WINIT) - ran for two years from January 2004 until March 2006 at the Information Systems Institute at The University of Salford and dealt solely with women who worked in the ICT sector in England. The WINIT Project via an online questionnaire and in-depth interviews gathered the stories and experiences of up to 500 participants and 19 interviewees respectively. The project enabled these women’s voices to be heard but the research team were constantly aware that a certain part of the female ICT workforce - the ‘disappearing’ women who had left ICT vowing never to return - had been overlooked and effectively silenced. It was these women who once found, may be able to facilitate a more in-depth understanding of why women were leaving the ICT sector. Having amassed skills and expertise, qualifications in ICT and crossed ICT recruitment barriers (DTI 2005a) the ‘disappearing’ women for whatever reasons decided to change their career trajectories and leave the sector. What ‘chilly’ (Falkner 2004) workplaces, disinterested organisational cultures and indifferent working conditions had these women encountered that became determining factors in leaving the ICT sector? There has been little (if any) research conducted involving this specific cohort of women and The Disappearing Women: North West ICT (DW: NW ICT) project seeks to make a research contribution to what is a continuing statistical and symbolic under-representation of women in the ICT labour market. The DW: NW ICT project was partly funded by the European Social Fund (ESF) from April 2006 until December 2006 under ESF Objective 3, Policy Field 5.1: Improving the Participation of Women. The DW: NW ICT project contributes research to priority 5 and its strategic objective to reduce the level of disadvantage faced by women in the labour market. The project was run in the Information Systems Group, Salford Business School of The University of Salford, Greater Manchester, UK. The report is structured as follows. The first section presents the backdrop for the research, looking in general at women in the ICT labour market in England and then women leaving the ICT sector focussing on the North West of England and more explicitly women leaving ICT employment in the North West of England. The research aims of the project form the following section; they have been loosely classified in to two groupings, the push and pull factors that are contributing to the high attrition rate of women leaving ICT. The methodology follows with the route taken in how this ‘hard to reach’ target sample were finally located, once contacted the life history interview process and procedures adopted is explained in full. The vignettes of the ‘disappearing’ women are included to allow the reader an opportunity to ‘get to know’ these women a little more closely. Key themes that have naturally emerged throughout the interview data analysis process are presented, including hostilities in the ICT workplace, significant events and the process of leaving ICT workplaces and finally stories of the ‘appearing’ women and their current situations are heard. A discussion regarding the findings of the DW: NW ICT project concludes this report

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas

Platinum drug-resistance in ovarian cancers is a major factor contributing to chemotherapeutic resistance of recurrent disease. Members of the Bcl-2 family such as the anti-apoptotic protein Bcl-XL have been shown to play a role in this resistance. Consequently, concurrent inhibition of Bcl-XL in combination with standard chemotherapy may improve treatment outcomes for ovarian cancer patients. Here, we develop a mathematical model to investigate the potential of combination therapy with ABT-737, a small molecule inhibitor of Bcl-XL, and carboplatin, a platinum-based drug, on a simulated tumor xenograft. The model is calibrated against in vivo\ud experimental data, wherein tumor xenografts were established in mice and treated with ABT-737 and carboplatin on a fixed periodic schedule, alone or in combination, and tumor sizes recorded regularly. We show that the validated model can be used to predict the minimum drug load that will achieve a predetermined level of tumor growth inhibition, thereby maximizing the synergy between the two drugs. Our simulations suggest that the time of infusion of each carboplatin dose is a critical parameter, with an 8-hour infusion of carboplatin administered each week combined with a daily bolus dose of ABT-737 predicted to minimize residual disease. We also investigate the potential of ABT-737 co-therapy with carboplatin to prevent or delay the onset of carboplatin-resistance under two scenarios. When resistance is acquired as a result of aberrant DNA-damage repair in cells treated with carboplatin, the model is used to identify drug delivery schedules that induce tumor remission with even low doses of combination therapy. When resistance is intrinsic, due to a pre-existing cohort of resistant cells, tumor remission is no longer feasible, but our model can be used to identify dosing strategies that extend disease-free survival periods. These results underscore the potential of our model to accelerate the development of novel therapeutics such as ABT-737, by predicting optimal treatment strategies when these drugs are given in combination with currently approved cancer medications

Improvements in estimating proportions of objects from multispectral data

Methods for estimating proportions of objects and materials imaged within the instantaneous field of view of a multispectral sensor were developed further. Improvements in the basic proportion estimation algorithm were devised as well as improved alien object detection procedures. Also, a simplified signature set analysis scheme was introduced for determining the adequacy of signature set geometry for satisfactory proportion estimation. Averaging procedures used in conjunction with the mixtures algorithm were examined theoretically and applied to artificially generated multispectral data. A computationally simpler estimator was considered and found unsatisfactory. Experiments conducted to find a suitable procedure for setting the alien object threshold yielded little definitive result. Mixtures procedures were used on a limited amount of ERTS data to estimate wheat proportion in selected areas. Results were unsatisfactory, partly because of the ill-conditioned nature of the pure signature set

Mentoring trainee psychologists: learning from lived experience

Purpose – To examine service-users’ experiences of mentoring trainee clinical psychologists as part of an involvement initiative on a doctoral training course. Methodology – Seven service-users were paired with trainee clinical psychologists. Pairs met for one hour monthly over 6 months. Meetings were unstructured, lacked a formal agenda and were not evaluated academically. All seven mentors were interviewed. They were asked about positive and negative experiences, as well as about the support provided. Transcripts were subject to thematic analysis and themes were reviewed by mentors in a follow-up meeting. Findings - Overall, results demonstrate that service-users can be involved in training in a way that they find meaningful and contributes to their recovery. Seven themes were identified: Giving hope and optimism; making a difference; personal and professional development; the process; practicalities/ logistics; support (positives); support (areas for improvement). Practical implications – The importance of designing involvement initiatives in a way which implicitly supports service-user values was highlighted. Recommendations for designing effective support structures are given. Authors were also involved in the scheme which could have introduced bias. Originality/value – Research exploring service-users’ experiences of involvement in training health professionals is limited. This was the first study to explore in depth service users’ perspectives of involvement in a scheme such as the Mentoring Scheme. If initiatives are to seriously embrace the values of the service-user movement then seeking service-users’ perspectives is vital. Paper type: Research Pape

First record of an Odontaspidid shark in Ascension Island waters

The occurrence of the poorly understood shark species Odontapsis ferox is reported at an oceanic seamount in the central south Atlantic, within the Exclusive Economic Zone of Ascension Island. The presence of the species at this location is confirmed by the discovery of a tooth embedded in scientific equipment, and footage of at least one animal on autonomous underwater video. The new record of this shark species at this location demonstrates the knowledge gaps which still exist at many remote, oceanic structures and their candidacy for status as important conservation areas.info:eu-repo/semantics/publishedVersio

Highly sensitive alkane odour sensors based on functionalised gold nanoparticles

We deposit dense, ordered, thin films of Au-dodecanethiol core/shell nanoparticles by the Langmuir-Schafer (LS) printing method, and find that their resistance at ambient temperature responds selectively and sensitively to alkane odours. Response is a rapid resistance increase due to swelling, and is strongest for alkane odours where the alkane chain is similar in length to the dodecane shell. For decane odours, we find a response to concentrations as low as 15 ppm, about 600 times below the lower explosive limit. Response is weaker, but still significant, to aromatic odours (e.g. Toluene, Xylene), while potential interferants such as polar and/or hydrogen-bonding odours (e.g. alcohols, ketones, water vapour) are somewhat rejected. Resistance is weakly dependent on temperature, and recovers rapidly and completely to its original value within the error margin of measurement. (C) 2011 Elsevier B.V. All rights reserved

Framing data witnessing: Airwars and the production of authority in conflict monitoring

Civilian victims of aerial warfare too often go uncounted and unrecognised by the belligerents. Myriad images and video of attacks against Syrian civilians did little to end their suffering, for example. The UK-based not-for-profit Airwars has had tangible impact on civilian harm disclosures and reparations because they have been able to shape such representations in a form that will be recognised by those with the power to enact change. Building on established theories of media witnessing and their extension to what Gray calls ‘data witnessing’, we argue that Airwars reveals the operative role of framing in open-source investigation and the forms of it witnessing it produces. Through interviews with key team members and detailed analysis of Airwars published methodology and other materials, this article shows how open-source investigations broadens the frame for witnessing civilian harm and in doing so generates relational, multi-scalar accounts of state violence that remain open to contestation and confirmation. In doing so, Airwars claims an epistemic authority via its distinctive framing of emergent practices of witnessing that depend upon the assembling of roles, standards, spatialities and techniques

Reaction Diffusion and Ballistic Annihilation Near an Impenetrable Boundary

The behavior of the single-species reaction process $A+A\to O$ is examined near an impenetrable boundary, representing the flask containing the reactants. Two types of dynamics are considered for the reactants: diffusive and ballistic propagation. It is shown that the effect of the boundary is quite different in both cases: diffusion-reaction leads to a density excess, whereas ballistic annihilation exhibits a density deficit, and in both cases the effect is not localized at the boundary but penetrates into the system. The field-theoretic renormalization group is used to obtain the universal properties of the density excess in two dimensions and below for the reaction-diffusion system. In one dimension the excess decays with the same exponent as the bulk and is found by an exact solution. In two dimensions the excess is marginally less relevant than the bulk decay and the density profile is again found exactly for late times from the RG-improved field theory. The results obtained for the diffusive case are relevant for Mg$^{2+}$ or Cd$^{2+}$ doping in the TMMC crystal's exciton coalescence process and also imply a surprising result for the dynamic magnetization in the critical one-dimensional Ising model with a fixed spin. For the case of ballistic reactants, a model is introduced and solved exactly in one dimension. The density-deficit profile is obtained, as is the density of left and right moving reactants near the impenetrable boundary.Comment: to appear in J. Phys.