1,085 research outputs found
Non-adjustment for multiple testing in multi-arm trials of distinct treatments: rationale and justification
Temporal trends in incidence of Rolandic Epilepsy, prevalence of comorbidities and prescribing trends: Birth Cohort Study
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Dendrimer-Encapsulated Nanoparticles: New Synthetic and Characterization Methods and Catalytic Applications
In this article we describe the synthesis, characterization, and applications of dendrimer-encapsulated nanoparticles (DENs). These materials are synthesized using a template approach in which metal ions are extracted into the interior of dendrimers and then subsequently reduced chemically to yield nearly size-monodisperse particles having diameters in the 1-2 nm range. Monometallic, bimetallic (alloy and core@shell), and semiconductor nanoparticles have been prepared by this route. The dendrimer component of these composites serves not only as a template for preparing the nanoparticle replica, but also as a stabilizer for the nanoparticle. In this perspective, we report on progress in the synthesis, characterization, and applications of these materials since our last review in 2005. Significant advances in the synthesis of core@shell DENs, characterization, and applications to homogeneous and heterogeneous catalysis (including electrocatalysis) are emphasized.U.S. Department of Energy, Office of Basic Energy Sciences DE-FG02-09ER16090U.S. National Science Foundation 0847957Robert A. Welch Foundation F-0032Chemistr
Positing the problem : enhancing classification of extremist web content through textual analysis
Webpages with terrorist and extremist content are key factors in the recruitment and radicalization of disaffected young adults who may then engage in terrorist activities at home or fight alongside terrorist groups abroad. This paper reports on advances in techniques for classifying data collected by the Terrorism and Extremism Network Extractor (TENE) web-crawler, a custom-written program that browses the World Wide Web, collecting vast amounts of data, retrieving the pages it visits, analyzing them, and recursively following the links out of those pages. The textual content is subjected to enhanced classification through software analysis, using the Posit textual analysis toolset, generating a detailed frequency analysis of the syntax, including multi-word units and associated part-of-speech components. Results are then deployed in a knowledge extraction process using knowledge extraction algorithms, e.g., from the WEKA system. Indications are that the use of the data enrichment through application of Posit analysis affords a greater degree of match between automatic and manual classification than previously attained. Furthermore, the incorporation and deployment of these technologies promises to provide public safety officials with techniques that can help to detect terrorist webpages, gauge the intensity of their content, discriminate between webpages that do or do not require a concerted response, and take appropriate action where warranted
Home Ranges and Spatial Organization of Fishers, Martes pennanti, in Central British Columbia
We described the size and spatial arrangement of aggregate and seasonal home ranges for 17 radio-tagged resident Fishers (Martes pennanti) that were >1.5 years old in two areas of central British Columbia during 1990-1993 and 1996-2000. We estimated home range size for each Fisher from the 95% isopleth of the utilization distribution generated using a fixed kernel model with smoothing selected by least-squares cross-validation (95% FK). For comparison to previous studies, we also calculated the minimum convex polygon estimate of home range size (MCP) for each animal. The aggregate home ranges (95% FK) of female Fishers (mean = 37.9 km², SD = 18.5, range = 10.5 – 81.2, n = 11) were significantly smaller than those of males (mean = 161.3 km², SD = 100.0, range = 46.0 – 225.2, n = 3; P = 0.019). We observed minor overlap among 95% FK home ranges of Fishers of the same sex, but considerable overlap among home ranges of males and females. Home ranges (95% FK or MCP) that we observed in central British Columbia were larger than those reported elsewhere in North America, particularly for males. We suggest that the distribution of resources for Fishers may occur at lower gross densitiesin central British Columbia than in other portions of the Fisher’s range and that suitable habitat in which Fishers can establish home ranges is not found uniformly across the landscape
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Plural bodily subjects: a radical account of thinking and acting together
The primary aim of this thesis is to defend the idea that there are ontologically collective forms of thought and action. This is to say, that there are at least some instances in which a thought or action is appropriately ascribed not to the individual members of a group, but only to the group as a whole. In chapters 2 and 4 existing attempts, primarily in analytic philosophy, to defend such phenomena by appealing to either the content, mode, or subject of intentional states are criticised. These criticisms in turn motivate an alternative understanding of subjectivity, outlined in chapters 3 and 5. This alternative draws on the phenomenological work of Dan Zahavi and Maurice Merleau-Ponty, to argue that subjectivity must be understood, firstly, as constituted by the pre-reflective self-awareness that is central to all intentional experience and, secondly, as intrinsically bodily. Finally, in chapter 6, and by drawing on Merleau-Ponty’s thoughts on habituation and intersubjectivity, it is argued that it is possible to understand groups as continually in the process of developing such a form of plural bodily subjectivity through processes of group-level habituation. Overall, therefore, a radical position will be defended, which holds that not only can groups think and act in an ontologically collective sense, but that they can do so in virtue of the fact that they can achieve a certain level of phenomenal self-consciousness. However, this position will be tempered by the thought that unified self-awareness and subjectivity is a matter of degree; where to have a unified pre-reflective sense of self is to be an individual subject, groups must be understood as always in the process of developing a form of unity that is, ultimately, out of their grasp
LOWER EXTREMITY COORDINATION VARIABILITY DURING ANTICIPATED AND UNANTICIPATED SIDESTEPPING: IMPLICATIONS FOR ACL INJURY PREVENTION
Non-contact anterior cruciate ligament (ACL) injuries commonly occur during sidestepping, particularly under time constraints. This study investigated the differences in lower limb coordination variability (CV) of five male team sport athletes during anticipated and unanticipated sidestepping. Intra-limb couplings associated with ACL injury mechanisms were investigated. Athletes demonstrated 21% greater thigh rot/leg rot CV; 31% greater thigh abd-add/leg abd-add CV; 22% greater knee flex-ext/hip rot CV and 14% greater hip rot/knee abd-add CV during unanticipated sidestepping. These results suggest that CV increases as a function of task complexity. Consequently, injury prevention programs must incorporate perceptual components in order to optimise planning time and coordinate appropriate postural adjustments to counter external loads
TASK CONSTRAINTS MODIFY INTRISIC HEAD-TRUNK DYNAMICS DURING RUNNING AND SIDESTEPPING
The purpose of this study was to examine head movement control during running and sidestepping tasks. Fourteen collegiate male athletes performed running and sidestepping tasks. Sagittal and transverse head and trunk angles, vertical trunk displacement and head-trunk coordination were assessed during the flight and stance phases. The sidestepping task resulted in greater transverse and sagittal plane head and trunk range of motion. During stance, transverse plane head-trunk coordination was more in-phase, with reduced vertical trunk-sagittal head anti-phase coordination during sidestepping tasks. During sidestepping tasks, visual field reorientation required greater contributions from the head in the transverse plane, but with reduced sagittal plane compensation, reduced perceptual awareness may be observed, with negative implications on sport performance and injury risk
Passage Through a Small Drainage Culvert by Mule Deer, Odocoilus hemionus, and Other Mammals
Cameras with infra-red triggers were used to monitor the passage of wildlife through underground passages that ran under a major highway and railway. Several species of mammals were detected traveling through the passages; of particular interest was the movement of Mule Deer (Odocoileus hemionus) through a relatively small culvert that would not have been predicted to see usage by these animals
Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis CHEST Guideline and Expert Panel Report
BACKGROUND: Wet or productive cough is common in children with chronic cough. We formulated recommendations based on systematic reviews related to the management of chronic wet cough in children (aged METHODS: We used the CHEST expert cough panel\u27s protocol for systematic reviews and the American College of Chest Physicians (CHEST) methodologic guidelines and GRADE framework (the Grading of Recommendations Assessment, Development and Evaluation). Data from the systematic reviews in conjunction with patients\u27 values and preferences and the clinical context were used to form recommendations. Delphi methodology was used to obtain consensus for the recommendations/suggestions made. RESULTS: Combining data from the systematic reviews, we found high-quality evidence in children aged 4 weeks\u27 duration) wet/productive cough that using appropriate antibiotics improves cough resolution, and further investigations (eg, flexible bronchoscopy, chest CT scans, immunity tests) should be undertaken when specific cough pointers (eg, digital clubbing) are present. When the wet cough does not improve following 4 weeks of antibiotic treatment, there is moderate-quality evidence that further investigations should be considered to look for an underlying disease. New recommendations include the recognition of the clinical diagnostic entity of protracted bacterial bronchitis. CONCLUSIONS: Compared with the 2006 Cough Guidelines, there is now high-quality evidence for some, but not all, aspects of the management of chronic wet cough in specialist settings. However, further studies (particularly in primary health) are required
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