Individual item fit for RHS in order of difficulty.

<p>Individual item fit for RHS in order of difficulty.</p

RHS Pilot sample demographics and discriminative/groups validity.

<p>RHS Pilot sample demographics and discriminative/groups validity.</p

SMA Type 3 sub analysis: RHS timed tests (all SMA 3a).

<p>SMA Type 3 sub analysis: RHS timed tests (all SMA 3a).</p

Revised Hammersmith Scale for Spinal Muscular Atrophy: Process of development.

<p>Iterative process of RHS development—expert panel, SMA outcome measure review, draft instrument, scale pilot and subsequent modification summarised for draft version 1, 2 and final version of the RHS.</p

Rasch analysis: RHS 17.03.2015 threshold map for items in RHS in ranked order of difficulty.

<p>The presence of horizontal bars indicates that for these items as an individual’s ability increases they would be more likely to achieve a higher score and that this would increase systematically in a logical progression. They would first score 0, then 1 and then 2 as ability improves. The inverse is also true. Within each bar a number 1 represents a score of 0 on the RHS, 2 represents a score of 1, and 3 represents a score of 2.</p

Overall properties of RHS using the Rasch measurement method.

<p>Overall properties of RHS using the Rasch measurement method.</p

Age stratification versus median RHS score (IQR).

<p>Age stratification versus median RHS score (IQR).</p

Discriminative/groups validity of the RHS.

<p>Median RHS total score (IQR and Range) versus a) SMA type combined with current ambulatory status; b) Highest current level of motor ability according to WHO groups.</p

Rasch analysis: RHS 17.03.2015 person item threshold distribution.

<p><b>Targeting of the patient sample (top) to individual items (bottom)</b>. The figure shows the targeting between the distribution of person measurements (upper histogram) and the distribution of the item locations (lower histogram).</p

Mean annual rate of change on the 6MWT, overall and by subgroup.

<p>Mean annual rate of change on the 6MWT, overall and by subgroup.</p