Planning for future uncertainties in electric power generation : an analysis of transitional strategies for reduction of carbon and sulfur emissions

The object of this paper is to identify strategies for the U.S. electric utility industry for reduction of both acid rain producing and global warming gases. The research used the EPRI Electric Generation Expansion Analysis System (EGEAS) utility optimization/simulation modeling structure and the EPRI developed regional utilities. It focuses on the North East and East Central region of the U.S. Strategies identified were fuel switching -- predominantly between coal and natural gas, mandated emission limits, and a carbon tax. The overall conclusions of the study are that using less (conservation) will always benefit Carbon Emissions but may or may not benefit Acid Rain emissions by the offsetting forces of improved performance of new plant as opposed to reduced overall consumption of final product. Results of the study are highly utility and regional demand specific. The study showed, however, that significant reductions in both acid rain and global warming gas production could be achieved with relatively small increases in the overall cost of production of electricity and that the current dispatch logics available to the utility control rooms were adequate to reschedule dispatch to meet these objectives.Supported by teh MIT Center for Energy Policy Research

Influence of Habitat and Number of Nestlings on Partial Brood Loss in Red-Cockaded Woodpeckers

Partial brood loss in red-cockaded woodpeckers (Picoides borealis) was studied during 2 breeding seasons in eastern Texas. The timing of partial brood loss, group size, number of initial nestlings, number of birds fledged, and habitat characteristics of the group\u27s cavity-tree cluster were examined for 37 woodpecker groups in loblolly- (Pinus taeda) shortleaf (P. echinata) pine habitat and 14 groups in longleaf (P palustris) pine habitat. Partial brood loss occurred slightly more in the loblolly-shortleaf pine habitat than in the longleaf pine habitat, largely because nests in loblolly-shortleaf habitat initially contained more nestlings. There was a trend for more young to be fledged by groups of 4 and 5 adult woodpeckers than by groups with only 2 or 3 adult birds. Partial brood loss was greater in nests with 4 initial nestlings than in nests with 3 or fewer nestlings. Partial brood loss was always observed in nests that initially contained 4 nestlings. When nests contained 3 nestlings, partial brood loss was significantly greater in clusters where hardwood midstory was present than in clusters where hardwood midstory was minimal, consistent with the brood reduction theory. Red-cockaded woodpeckers typically laid more eggs than they could possibly fledge young, lending support to the insurance egg hypothesis

A 2km-size asteroid challenging the rubble-pile spin barrier – A case for cohesion

The rubble pile spin barrier is an upper limit on the rotation rate of asteroids larger than ~200-300. m. Among thousands of asteroids with diameters larger than ~300. m, only a handful of asteroids are known to rotate faster than 2.0. h, all are in the sub-km range (≤0.6. km). Here we present photometric measurements suggesting that (60716) 2000 GD65, an S-complex, inner-main belt asteroid with a relatively large diameter of 2.3-0.7+0.6km, completes one rotation in 1.9529. ±. 0.0002. h. Its unique diameter and rotation period allow us to examine scenarios about asteroid internal structure and evolution: a rubble pile bound only by gravity; a rubble-pile with strong cohesion; a monolithic structure; an asteroid experiencing mass shedding; an asteroid experiencing YORP spin-up/down; and an asteroid with a unique octahedron shape results with a four-peak lightcurve and a 3.9. h period. We find that the most likely scenario includes a lunar-like cohesion that can prevent (60716) 2000 GD65 from disrupting without requiring a monolithic structure or a unique shape. Due to the uniqueness of (60716) 2000 GD65, we suggest that most asteroids typically have smaller cohesion than that of lunar regolith. Keywords: Asteroids; Asteroids, rotation; Rotational dynamics; PhotometryUnited States. National Aeronautics and Space Administration (Grant NNX12AL26G

An international comparative study of blood pressure in populations of European vs. African descent

Background: The consistent finding of higher prevalence of hypertension in US blacks compared to whites has led to speculation that African-origin populations are particularly susceptible to this condition. Large surveys now provide new information on this issue. Methods: Using a standardized analysis strategy we examined prevalence estimates for 8 white and 3 black populations (N = 85,000 participants). Results: The range in hypertension prevalence was from 27 to 55% for whites and 14 to 44% for blacks. Conclusions: These data demonstrate that not only is there a wide variation in hypertension prevalence among both racial groups, the rates among blacks are not unusually high when viewed internationally. These data suggest that the impact of environmental factors among both populations may have been under-appreciated

Randomised controlled trial of population screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the SAFER trial

Introduction: There is a lack of evidence that the benefits of screening for atrial fibrillation (AF) outweigh the harms. Following the completion of the Screening for Atrial Fibrillation with ECG to Reduce stroke (SAFER) pilot trial, the aim of the main SAFER trial is to establish whether population screening for AF reduces incidence of stroke risk. Methods and analysis: Approximately 82 000 people aged 70 years and over and not on oral anticoagulation are being recruited from general practices in England. Patients on the palliative care register or residents in a nursing home are excluded. Eligible people are identified using electronic patient records from general practices and sent an invitation and consent form to participate by post. Consenting participants are randomised at a ratio of 2:1 (control:intervention) with clustering by household. Those randomised to the intervention arm are sent an information leaflet inviting them to participate in screening, which involves use of a handheld single-lead ECG four times a day for 3 weeks. ECG traces identified by an algorithm as possible AF are reviewed by cardiologists. Participants with AF are seen by a general practitioner for consideration of anticoagulation. The primary outcome is stroke. Major secondary outcomes are: death, major bleeding and cardiovascular events. Follow-up will be via electronic health records for an average of 4 years. The primary analysis will be by intention-to-treat using time-to-event modelling. Results from this trial will be combined with follow-up data from the cluster-randomised pilot trial by fixed-effects meta-analysis. Ethics and dissemination: The London—Central National Health Service Research Ethics Committee (19/LO/1597) provided ethical approval. Dissemination will include public-friendly summaries, reports and engagement with the UK National Screening Committee. Trial registration number: ISRCTN72104369

Blood Pressure Changes Following Antihypertensive Medication Reduction, by Drug Class and Dose Chosen for Withdrawal: Exploratory Analysis of Data From the OPTiMISE Trial

Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with polypharmacy, but there is little evidence to inform which drug (or dose) should be withdrawn. This study used data from the OPTiMISE trial to examine whether short-term outcomes of deprescribing vary by drug class and dose of medication withdrawn. Methods: The OPTiMISE trial included patients aged ≥80 years with controlled systolic blood pressure (SBP; <150 mmHg), receiving ≥2 antihypertensive medications. This study compared SBP control, mean change in SBP and frequency of adverse events after 12 weeks in participants stopping one medication vs. usual care, by drug class and equivalent dose of medication withdrawn. Equivalent dose was determined according to the defined daily dose (DDD) of each medication type. Drugs prescribed below the DDD were classed as low dose and those prescribed at ≥DDD were described as higher dose. Outcomes were examined by generalized linear mixed effects models. Results: A total of 569 participants were randomized, aged 85 ± 3 years with controlled blood pressure (mean 130/69 mmHg). Within patients prescribed calcium channel blockers, higher dose medications were more commonly selected for withdrawal (90 vs. 10%). In those prescribed beta-blockers, low dose medications were more commonly chosen (87 vs. 13%). Withdrawal of calcium channel blockers was associated with an increase in SBP (5 mmHg, 95%CI 0–10 mmHg) and reduced SBP control (adjusted RR 0.89, 95%CI 0.80–0.998) compared to usual care. In contrast, withdrawal of beta-blockers was associated with no change in SBP (−4 mmHg, 95%CI −10 to 2 mmHg) and no difference in SBP control (adjusted RR 1.15, 95%CI 0.96–1.37). Similarly, withdrawal of higher dose medications was associated with an increase in SBP but no change in BP control. Withdrawal of lower dose medications was not associated with a difference in SBP or SBP control. There was no association between withdrawal of specific drug classes and adverse events. Conclusion: These exploratory data suggest withdrawal of higher dose calcium channel blockers should be avoided if the goal is to maintain BP control. However, low dose beta-blockers may be removed with little impact on blood pressure over 12-weeks of follow-up. Larger studies are needed to confirm these associations

Hsp90 governs dispersion and drug resistance of fungal biofilms

Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires surgical removal of infected devices. Here we implicate the molecular chaperone Hsp90 as a key regulator of biofilm dispersion and drug resistance. We previously established that in the leading human fungal pathogen, Candida albicans, Hsp90 enables the emergence and maintenance of drug resistance in planktonic conditions by stabilizing the protein phosphatase calcineurin and MAPK Mkc1. Hsp90 also regulates temperature-dependent C. albicans morphogenesis through repression of cAMP-PKA signalling. Here we demonstrate that genetic depletion of Hsp90 reduced C. albicans biofilm growth and maturation in vitro and impaired dispersal of biofilm cells. Further, compromising Hsp90 function in vitro abrogated resistance of C. albicans biofilms to the most widely deployed class of antifungal drugs, the azoles. Depletion of Hsp90 led to reduction of calcineurin and Mkc1 in planktonic but not biofilm conditions, suggesting that Hsp90 regulates drug resistance through different mechanisms in these distinct cellular states. Reduction of Hsp90 levels led to a marked decrease in matrix glucan levels, providing a compelling mechanism through which Hsp90 might regulate biofilm azole resistance. Impairment of Hsp90 function genetically or pharmacologically transformed fluconazole from ineffectual to highly effective in eradicating biofilms in a rat venous catheter infection model. Finally, inhibition of Hsp90 reduced resistance of biofilms of the most lethal mould, Aspergillus fumigatus, to the newest class of antifungals to reach the clinic, the echinocandins. Thus, we establish a novel mechanism regulating biofilm drug resistance and dispersion and that targeting Hsp90 provides a much-needed strategy for improving clinical outcome in the treatment of biofilm infections

Measuring emotional support in family networks: Adapting the Family Network Method for individuals with a mild intellectual disability.

Informal supportive networks of individuals with intellectual disability have become increasingly important. The aim of this paper is to describe how the Family Network Method - Intellectual Disability (FNM-ID) offers a way to gather the perspective of people with mild intellectual disability on their family support. The FNM is designed to explore how individuals define their family contexts, and more specifically how they perceive existing supportive relationships in these contexts. By carefully piloting ways of questioning people with mild intellectual disability, systematic adaptations were made to the original FNM. Data obtained by the FNM-ID can be analysed using social network analysis. Thereby, the FNM-ID provides rich, theoretically significant information on emotional support in the family networks of individuals with mild intellectual disability. The FNM-ID is a useful and successfully adapted tool for other researchers and professionals to systematically explore the family support experiences of individuals with mild intellectual disability