Designing Affordable Housing out of Shipping Containers for Chicago (Semester Unknown) IPRO 339: DesigningAffordableHousingOutOfShippingContainersForChicagoIPRO339FinalReportSu09

The City of Chicago has been nominated as the U.S. Bid City for 2016 Olympic Games and currently remains a strong contender for this title. If Chicago is selected as the Host City it will face the enormous task of providing temporary housing for all Olympiad participants including athletes, coaches, organizers, and media reporters. Continuing in the vein of last semester’s IPRO, our IPRO is proposing an economical and environmentally friendly solution to this challenge. We propose to utilize thousands of old shipping containers that are cluttering up shipping yards in the Chicago area and to convert them into low-cost housing units. With proper foresight, this challenge can become an opportunity for the I P R O 3 3 9 City to demonstrate an attitude of sustainability that can serve as a model for other cities around the world to follow suit. The intense media attention directed towards the Olympic Games could be channeled to showcase our commitment to environmentally and socially responsible actions.Deliverable

Designing Affordable Housing out of Shipping Containers for Chicago (Semester Unknown) IPRO 339: DesigningAffordableHousingOutOfShippingContainersForChicagoIPRO339BrochureSu09

The City of Chicago has been nominated as the U.S. Bid City for 2016 Olympic Games and currently remains a strong contender for this title. If Chicago is selected as the Host City it will face the enormous task of providing temporary housing for all Olympiad participants including athletes, coaches, organizers, and media reporters. Continuing in the vein of last semester’s IPRO, our IPRO is proposing an economical and environmentally friendly solution to this challenge. We propose to utilize thousands of old shipping containers that are cluttering up shipping yards in the Chicago area and to convert them into low-cost housing units. With proper foresight, this challenge can become an opportunity for the I P R O 3 3 9 City to demonstrate an attitude of sustainability that can serve as a model for other cities around the world to follow suit. The intense media attention directed towards the Olympic Games could be channeled to showcase our commitment to environmentally and socially responsible actions.Deliverable

Designing Affordable Housing out of Shipping Containers for Chicago (Semester Unknown) IPRO 339: DesigningAffordableHousingOutOfShippingContainersForChicagoIPRO339PosterSu09

The City of Chicago has been nominated as the U.S. Bid City for 2016 Olympic Games and currently remains a strong contender for this title. If Chicago is selected as the Host City it will face the enormous task of providing temporary housing for all Olympiad participants including athletes, coaches, organizers, and media reporters. Continuing in the vein of last semester’s IPRO, our IPRO is proposing an economical and environmentally friendly solution to this challenge. We propose to utilize thousands of old shipping containers that are cluttering up shipping yards in the Chicago area and to convert them into low-cost housing units. With proper foresight, this challenge can become an opportunity for the I P R O 3 3 9 City to demonstrate an attitude of sustainability that can serve as a model for other cities around the world to follow suit. The intense media attention directed towards the Olympic Games could be channeled to showcase our commitment to environmentally and socially responsible actions.Deliverable

Designing Affordable Housing out of Shipping Containers for Chicago (Semester Unknown) IPRO 339

The City of Chicago has been nominated as the U.S. Bid City for 2016 Olympic Games and currently remains a strong contender for this title. If Chicago is selected as the Host City it will face the enormous task of providing temporary housing for all Olympiad participants including athletes, coaches, organizers, and media reporters. Continuing in the vein of last semester’s IPRO, our IPRO is proposing an economical and environmentally friendly solution to this challenge. We propose to utilize thousands of old shipping containers that are cluttering up shipping yards in the Chicago area and to convert them into low-cost housing units. With proper foresight, this challenge can become an opportunity for the I P R O 3 3 9 City to demonstrate an attitude of sustainability that can serve as a model for other cities around the world to follow suit. The intense media attention directed towards the Olympic Games could be channeled to showcase our commitment to environmentally and socially responsible actions.Deliverable

Designing Affordable Housing out of Shipping Containers for Chicago (Semester Unknown) IPRO 339: DesigningAffordableHousingOutOfShippingContainersForChicagoIPRO339ProjectPlanSu09_redacted

The City of Chicago has been nominated as the U.S. Bid City for 2016 Olympic Games and currently remains a strong contender for this title. If Chicago is selected as the Host City it will face the enormous task of providing temporary housing for all Olympiad participants including athletes, coaches, organizers, and media reporters. Continuing in the vein of last semester’s IPRO, our IPRO is proposing an economical and environmentally friendly solution to this challenge. We propose to utilize thousands of old shipping containers that are cluttering up shipping yards in the Chicago area and to convert them into low-cost housing units. With proper foresight, this challenge can become an opportunity for the I P R O 3 3 9 City to demonstrate an attitude of sustainability that can serve as a model for other cities around the world to follow suit. The intense media attention directed towards the Olympic Games could be channeled to showcase our commitment to environmentally and socially responsible actions.Deliverable

Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trialResearch in context

Summary: Background: Anti-COVID-19 hyperimmune immunoglobulin (hIG) can provide standardized and controlled antibody content. Data from controlled clinical trials using hIG for the prevention or treatment of COVID-19 outpatients have not been reported. We assessed the safety and efficacy of subcutaneous anti-COVID-19 hyperimmune immunoglobulin 20% (C19-IG20%) compared to placebo in preventing development of symptomatic COVID-19 in asymptomatic individuals with SARS-CoV-2 infection. Methods: We did a multicentre, randomized, double-blind, placebo-controlled trial, in asymptomatic unvaccinated adults (≥18 years of age) with confirmed SARS-CoV-2 infection within 5 days between April 28 and December 27, 2021. Participants were randomly assigned (1:1:1) to receive a blinded subcutaneous infusion of 10 mL with 1 g or 2 g of C19-IG20%, or an equivalent volume of saline as placebo. The primary endpoint was the proportion of participants who remained asymptomatic through day 14 after infusion. Secondary endpoints included the proportion of individuals who required oxygen supplementation, any medically attended visit, hospitalisation, or ICU, and viral load reduction and viral clearance in nasopharyngeal swabs. Safety was assessed as the proportion of patients with adverse events. The trial was terminated early due to a lack of potential benefit in the target population in a planned interim analysis conducted in December 2021. ClinicalTrials.gov registry: NCT04847141. Findings: 461 individuals (mean age 39.6 years [SD 12.8]) were randomized and received the intervention within a mean of 3.1 (SD 1.27) days from a positive SARS-CoV-2 test. In the prespecified modified intention-to-treat analysis that included only participants who received a subcutaneous infusion, the primary outcome occurred in 59.9% (91/152) of participants receiving 1 g C19-IG20%, 64.7% (99/153) receiving 2 g, and 63.5% (99/156) receiving placebo (difference in proportions 1 g C19-IG20% vs. placebo, −3.6%; 95% CI -14.6% to 7.3%, p = 0.53; 2 g C19-IG20% vs placebo, 1.1%; −9.6% to 11.9%, p = 0.85). None of the secondary clinical efficacy endpoints or virological endpoints were significantly different between study groups. Adverse event rate was similar between groups, and no severe or life-threatening adverse events related to investigational product infusion were reported. Interpretation: Our findings suggested that administration of subcutaneous human hyperimmune immunoglobulin C19-IG20% to asymptomatic individuals with SARS-CoV-2 infection was safe but did not prevent development of symptomatic COVID-19. Funding: Grifols