Mixed Reality for Orthopedic Elbow Surgery Training and Operating Room Applications: A Preliminary Analysis

The use of Mixed Reality in medicine is widely documented to be a candidate to revolutionize surgical interventions. In this paper we present a system to simulate k-wire placement, that is a common orthopedic procedure used to stabilize fractures, dislocations, and other traumatic injuries. With the described system, it is possible to leverage Mixed Reality (MR) and advanced visualization techniques applied on a surgical simulation phantom to enhance surgical training and critical orthopedic surgical procedures. This analysis is centered on evaluating the precision and proficiency of k-wire placement in an elbow surgical phantom, designed with a 3D modeling software starting from a virtual 3D anatomical reference. By visually superimposing 3D reconstructions of internal structures and the target K-wire positioning on the physical model, it is expected not only to improve the learning curve but also to establish a foundation for potential real-time surgical guidance in challenging clinical scenarios. The performance is measured as the difference between K-wires real placement in respect to target position; the quantitative measurements are then used to compare the risk of iatrogenic injury to nerves and vascular structures of MR- guided vs non MR-guided simulated interventions

La verità visibile nella natura e nella scrittura. Sul baco da seta di Khamis bar Qardahe (fine del XIII secolo)

Khamis bar Qardaḥe was an East Syrian author active in the last decades of the 13th century, probably a representative member of the East-Syrian community at the court camp of the Il-Khans, and somehow connected with the town of Arbela. In the present article, his poetic work is presented in the broader context of the so-called ‘Syriac Renaissance’, as an example of late East-Syriac literature profoundly influenced by Persian poetry. The poem On the Silk-Worm is here critically edited and translated for the first time into a European language. Its complicated imagery turns out to be an interesting mélange of philosophical concepts, meta-literary reflection – poetry as a way to knowledge and salvation –, Christian themes – including the virginal conception of Mary –, and Persian, possibly Sufic, motifs. The monorhyme poem is rich with sound figures such as alliteration and etymological play

La verità visibile nella natura e nella scrittura: Sul baco da seta di Khamis bar Qardaḥe (fine del XIII secolo)

Khamis bar Qardaḥe was an East Syrian author active in the last decades of the 13th century, probably a representative member of the East-Syrian community at the court camp of the Il-Khans, and somehow connected with the town of Arbela. In the present article, his poetic work is presented in the broader context of the so-called ‘Syriac Renaissance’, as an example of late East-Syriac literature profoundly influenced by Persian poetry. The poem On the Silk-Worm is here critically edited and translated for the first time into a European language. Its complicated imagery turns out to be an interesting mélange of philosophical concepts, meta-literary reflection – poetry as a way to knowledge and salvation –, Christian themes – including the virginal conception of Mary –, and Persian, possibly Sufic, motifs. The monorhyme poem is rich with sound figures such as alliteration and etymological play

La verit\ue0 visibile nella natura e nella scrittura: Sul baco da seta di Khamis bar Qarda\u1e25e (fine del XIII secolo)

Khamis bar Qarda\u1e25e was an East Syrian author active in the last decades of the 13th century, probably a representative member of the East-Syrian community at the court camp of the Il-Khans, and somehow connected with the town of Arbela. In the present article, his poetic work is presented in the broader context of the so-called \u2018Syriac Renaissance\u2019, as an example of late East-Syriac literature profoundly influenced by Persian poetry. The poem On the Silk-Worm is here critically edited and translated for the first time into a European language. Its complicated imagery turns out to be an interesting m\ue9lange of philosophical concepts, meta-literary reflection \u2013 poetry as a way to knowledge and salvation \u2013, Christian themes \u2013 including the virginal conception of Mary \u2013, and Persian, possibly Sufic, motifs. The monorhyme poem is rich with sound figures such as alliteration and etymological play

CNVs analysis in a cohort of isolated and syndromic DD/ID reveals novel genomic disorders, position effects and candidate disease genes

Array-comparative genomic hybridization (array-CGH) is a widely used technique to detect Copy Number Variants (CNVs) associated with developmental delay/intellectual disability (DD/ID). We performed a comprehensive array-CGH investigation of 1,015 consecutive cases with DD/ID and combined literature mining, genetic evidence, evolutionary constraint scores, and functional information in order to assess the pathogenicity of the CNVs. We identified non-benign CNVs in 29% of patients. Amongst the pathogenic variants (11%), detected with a yield consistent with the literature, we found rare genomic disorders and CNVs spanning known disease genes. We further identified and discussed 51 cases with likely pathogenic CNVs spanning novel candidate genes, including genes encoding synaptic components and/or proteins involved in corticogenesis. Additionally, we identified two deletions spanning potential Topological Associated Domain (TAD) boundaries likely affecting the regulatory landscape. In conclusion, we show how phenotypic and genetic analyses of array-CGH data allow unraveling complex cases, identifying rare disease genes, and revealing unexpected position effects

Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry

International audienceBackground and Aims Even though vegetation size in infective endocarditis (IE) has been associated with embolic events (EEs) and mortality risk, it is unclear whether vegetation size associated with these potential outcomes is different in left-sided IE (LSIE). This study aimed to seek assessing the vegetation cut-off size as predictor of EE or 30-day mortality for LSIE and to determine risk predictors of these outcomes. Methods The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis is a prospective, multicentre registry including patients with definite or possible IE throughout 2016–18. Cox multivariable logistic regression analysis was performed to assess variables associated with EE or 30-day mortality. Results There were 2171 patients with LSIE (women 31.5%). Among these affected patients, 459 (21.1%) had a new EE or died in 30 days. The cut-off value of vegetation size for predicting EEs or 30-day mortality was >10 mm [hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.13–1.69, P = .0015]. Other adjusted predictors of risk of EE or death were as follows: EE on admission (HR 1.89, 95% CI 1.54–2.33, P < .0001), history of heart failure (HR 1.53, 95% CI 1.21–1.93, P = .0004), creatinine >2 mg/dL (HR 1.59, 95% CI 1.25–2.03, P = .0002), Staphylococcus aureus (HR 1.36, 95% CI 1.08–1.70, P = .008), congestive heart failure (HR 1.40, 95% CI 1.12–1.75, P = .003), presence of haemorrhagic stroke (HR 4.57, 95% CI 3.08–6.79, P < .0001), alcohol abuse (HR 1.45, 95% CI 1.04–2.03, P = .03), presence of cardiogenic shock (HR 2.07, 95% CI 1.29–3.34, P = .003), and not performing left surgery (HR 1.30 95% CI 1.05–1.61, P = .016) (C-statistic = .68). Conclusions Prognosis after LSIE is determined by multiple factors, including vegetation size