6G Vision: Towards Future Collaborative Cognitive Communication (3C) Systems

6G networks are expected to have a breakthrough by enabling the emergence of collaborative cognitive communication services over heterogeneous environments for industry 5.0 applications. These applications are required to adapt human-centric approach to make the most of human intuition and intelligence in Industry 4.0 automation.It calls for a transdisciplinarity research domain to investigate innovative systems with overlapping realms of Psychology, Sociology, Communication networks, Artificial Intelligence , Natural Language Processing and Collaborative Computing. The author at the Cognitive Systems Research Centre, London South Bank University has coined the expression “3C Systems" to refer to such artifacts which stands for "Collaborative Cognitive Communication Systems”. In this paper, an innovative framework for 3C Systems is proposed that is able to analyze and predict both the human as well as machine behaviors. It proactively diagnoses issues and recommends solutions without requiring any human intervention. The proposed concept of 3C Systems would potentially contribute towards 6G standardization. The automation and orchestration aspects of this research have variety of applications stretched across city infrastructures, retail, business, tourism, health, law, education and travel. A thorough insight to a broad view of 6G vision has been presented towards envisioned 3C Systems, while covering its enabling technologies. The experimental results for the proof of concept implementation has been presented. Results affirm the technical capabilities of the concept, to contribute to several industry 5.0 applications including, but not limited to holographic communication, self-driving vehicles, context-aware infrastructure and personalized interfaces

Asthma diagnosis and treatment - 1012. The efficacy of budesonide in the treatmetn of acute asthma in children: a double-blind, randomized, controlled trial.

Background Current evidence suggests that inhaled glucocorticoids (IGC) have a more profound topical none genomic effect on bronchial airways as compared to systemic glucocorticoids. The value of adding IGC to current therapy of acute asthma is not well established. Methods We conducted a double-blind, randomized, two-arm, parallel groups, controlled clinical trial to compare the addition of budesonide 1500 mcg or placebo (normal saline) to standard acute asthma treatment (albuterol and ipratropium bromide) administered in 3 divided mixed doses within 1 hour in the emergency department (ED). Children 2-12 years of age with moderate or severe acute asthma, scoring 8-15/15 on a well-validated scoring system were included. Both groups received a single dose of prednisone 2 mg/kg/day (max. 60 mg) at the beginning of therapy. The primary outcome was admission rate within 2-4 hours from starting therapy. Results A total of 723 children were enrolled in the study over 17 months duration, of whom 139 were allowed to re-enroll and be randomized to constitute 906 randomization assignments (458 on the treatment group and 448 on the control group); with baseline mean + SD asthma score of 10.63 + 1.73; age 5.52 + 2.76 years; 35% girls; 30.8% (16.5%) with baseline severe asthma score of ≥12 (≥ 13). Statistical Analysis plan allowed for the potential dependency in response due to reenrollments of a subset of children, using Generalized Linear Mixed Modeling (GLMM) techniques. Baseline demographic and clinical characteristics were not significantly different between the two randomized groups. Seventy-five out of 458 (16.4%) of the treatment group vs. 82/448 (18.3%) of the control group were admitted, (OR 0.85, CI: 0.59-1.23, p-value=0.39). Among the severe asthmatics with baseline score ≥13, treatment vs. placebo group, GLMM adjusted admission rate was 30% vs. 47%, indicating a 17% difference in admission rate in favor of the treatment group (adjusted OR of 0.49, CI: 0.25-0.95; p-value= 0.035) that indicated a 51% reduction in the risk of admission for the treatment vs. control group. Conclusions Children with baseline severe asthma score ≥13 who were treated with budesonide had a significant reduction in their admission rate

Gallstone ileus: retrospective review of a single centre\u27s experience using two surgical procedures

Introduction:Gallstone ileus is responsible for 1-3 percent of cases of mechanical small bowel obstruction. Debate continues regarding choice of optimal surgical procedure. One-stage procedure includes enterolithotomy, cholecystectomy and repair of fistula at the same setting, whereas staged procedure includes enterolithotomy alone, with fistula repair at a later stage. This study aims to determine factors influencing choice of surgical procedure in Patients with gallstone ileus. Methods : Data was collected for Patients diagnosed with gallstone ileus between 1990 and 2005. Five Patients underwent enterolithotomy alone (Group 1), while the remaining five Patients underwent enterolithotomy with cholecystectomy and repair of fistula as a single stage procedure (Group 2). Results: In Group 1, Patients presented late with deranged physiological parameters and pre-existing comorbidities accounting for an American Society of Anesthesiologists (ASA) score of 3 or above. In Group 2, Patients presented early with preserved physiological status accounting for an ASA score of 2. The mean operative time was 126 +/- 23 minutes in Group 1 and 245 +/- 54.4 minutes in Group 2. There was no mortality, three Patients in Group 1 had superficial wound infection, and one Patient in Group 2 had injury to the common bile duct necessitating hepaticojejunostomy. The mean follow-up period was 3.5 +/- 1.5 years. None of the Patients in both groups had recurrent symptoms requiring further intervention. Conclusions: Choice of surgical procedure was largely determined by the clinical status of the Patient. Single-stage procedure was performed in haemodynamically-stable Patients, while enterolithotomy alone was considered sufficient for unstable Patients

Completeness of case ascertainment and survival time error in English cancer registries: impact on 1-year survival estimates.

BACKGROUND: It has been suggested that cancer registries in England are too dependent on processing of information from death certificates, and consequently that cancer survival statistics reported for England are systematically biased and too low. METHODS: We have linked routine cancer registration records for colorectal, lung, and breast cancer patients with information from the Hospital Episode Statistics (HES) database for the period 2001-2007. Based on record linkage with the HES database, records missing in the cancer register were identified, and dates of diagnosis were revised. The effects of those revisions on the estimated survival time and proportion of patients surviving for 1 year or more were studied. Cases that were absent in the cancer register and present in the HES data with a relevant diagnosis code and a relevant surgery code were used to estimate (a) the completeness of the cancer register. Differences in survival times calculated from the two data sources were used to estimate (b) the possible extent of error in the recorded survival time in the cancer register. Finally, we combined (a) and (b) to estimate (c) the resulting differences in 1-year cumulative survival estimates. RESULTS: Completeness of case ascertainment in English cancer registries is high, around 98-99%. Using HES data added 1.9%, 0.4% and 2.0% to the number of colorectal, lung, and breast cancer registrations, respectively. Around 5-6% of rapidly fatal cancer registrations had survival time extended by more than a month, and almost 3% of rapidly fatal breast cancer records were extended by more than a year. The resulting impact on estimates of 1-year survival was small, amounting to 1.0, 0.8, and 0.4 percentage points for colorectal, lung, and breast cancer, respectively. INTERPRETATION: English cancer registration data cannot be dismissed as unfit for the purpose of cancer survival analysis. However, investigators should retain a critical attitude to data quality and sources of error in international cancer survival studies

Evaluation of the genetic structure of the urban dwelling species of Bank Myna (Acridotheres ginginisnus) using random amplified polymorphic DNA (RAPD) analysis

We used the random amplified polymorphic DNA (RAPD) technique to decipher the genetic structure of the Bank Myna (Acridotheres ginginisnus) in Pakistan. The samples were collected from four cities namely: Dera Ghazi Khan, Jahanian, Khanewal and Gujranwala. The analysis showed a high genetic diversity at species level (H = 0.318, S = 0.467) but low levels at population levels (H = 0.047, S = 0.069 to H = 0.195, S = 0.283). The four populations analyzed were genetically distant from each other and hinted the effect of urbanization role in isolating the urban dwelling species. The genetic distances between populations ranged from D = 0.2403 to D = 0.3419 and the similarity coefficient showed low range from 0.66 to 0.70. This study will help in future conservation plans and also help the understanding of the role of urbanization on fragmentation of species’ natural distribution and dispersal mechanism.Key words: Acridotheres ginginisnus, Bank Myna, random amplified polymorphic DNA (RAPD), genetic structure

Population genetic structure of Rufous-Vented Prinia (Prinia burnesii) in Pakistan

The objective of the study is to ascertain genetic variation within Rufous-vented Prinia, Prinia burnesii an endemic species, by DNA fingerprinting applying random amplified polymorphic DNA (RAPD) technique. Genetic material was obtained from three distant sites along western bank of River Indus. These sites include Chashma barrage (32°50’N, 71°20’E), in the north; Taunsa barrage (30°45’N, 70°45’E) and the southern population from Guddu barrage (28°26’N, 69°44’E). In total, 14 RAPD primers were selected to determine the genetic variability between three populations of the species. The Nei’s (1973) genetic diversity in three populations ranged from 0.190 to 0.320. The genetic distance between Populations ranged from 0.149 to 0.265. The polymorphism levels ranged from 48 to 83% in three populations and at species level, polymorphism were 93.07%. The results further indicate that they are genetically isolated populations.Keywords: Random Amplified Polymorphic DNA, Prinia, genetic variation, river Indu

Cloning and expression of Toxoplasma gondii tachyzoite P22 protein

Delay in diagnosis of Toxoplasma gondii infection in pregnant women who have been infected during the first trimester of gestation can lead to death of her fetus. Serological tests based on recombinant proteins are the main diagnosis methods for the detection of anti Toxoplasma antibody in serum samples. The aim of this study was to clone and express a gene encoding a P22 protein of T. gondii tachyzoite as using antigen for ELISA serology method. DNA was extracted from T. gondii (RH-strain) tachyzoites and PCR reaction was done using corresponding primers. The PCR product was purified, ligated to PTZ57R plasmid via T/A cloning method and subcloned into SacI and BamHI digested pET32a expression vector. Recombinant plasmid was transformed in E. coli (Bl21 DE3) and induced by 1 mM IPTG and analyzed by 12% SDS-PAGE. Expressd protein was purified by affinity chromatography and confirmed by western blot analysis. We successfully cloned and expressed T. gondii P22 protein.Key words: Toxoplasma gondii, cloning, recombinant P22

Environmental health and wildlife researchwith transnational education forebodings, applicability and approach

Pakistan, the sixth most populous country (91.71 million)in the world, is battling to keep the balance between economic growth and environmental protection. At present the government is mainly focusing on meeting the energy and food needs of the country and environmental protection is lacking serious attention. Pollution (air, water, and soil), sanitation and loss of wildlife and biodiversity are growing environmental health issues in Pakistan. In order to deliver demand led solutions to these multifaceted challenges development of institutional and technical capacities in the countryis prerequisite. Transnational Education (TNE) provides institutional mobility in tertiary education and through British Council facilitated links we were successful in developing a much needed baseline courses work and underway the research for environmental health related issues. The Government of Pakistan will certainly use the data from the research and experts will also be available to concerned departments to tackle emerging environmental problems. Additionally the understanding and concerns of TNE in academic, economic, career and socio-cultural contexts could be imperative challenges. Through TNE it was learned that other nations / regions can be benefitted from such institutes and concerned people for a true flow of knowledge for reciprocated problems. The recommendations include general considerations for policy makers which are linked with environmental health and wildlife. Among the general considerations, or overarching advice, is that policies should promote community-wide action to manage wildlife, biodiversity, environmental health and that the safety of new emissions and exposure with technologies must be assessed rather than estimated

Development and Operation Analysis of Spectrum Monitoring Subsystem 2.4–2.5 GHz Range

The paper presents a substantiation of the effectiveness of IEEE 802.11 wireless network analysis subsystem implementation using miniature spectrum analyzers. Also it was given an overview of firmware work scheme, development process of trial versions, monitoring system development approaches, current development stage, infrastructure for research system, reliability and scan check, our system design and hardware implementation, future work, etc. Paper also provides technical solutions on automation, optimal algorithms searching, errors correcting, organizing software according to the Model-View-Controller scheme, harmonizing data exchange protocols, storing and presenting the obtained results