Genital warts and sexual abuse in children. American Academy of Dermatology Task Force on Pediatric Dermatology

Genital warts in children indicate the possibility of sexual abuse. If sexual child abuse is recognized or suspected, then the law in all states requires that the physician report this to the appropriate authority. The dermatologist may be the first person to suspect the problem and can be of great help in protecting the child from future harm

Development of a quality-of-life instrument for autoimmune bullous disease: The autoimmune bullous disease quality of life questionnaire

IMPORTANCE Quality-of-life (QOL) evaluation is an increasingly important outcome measure in dermatology, with disease-specific QOL instruments being the most sensitive to changes in disease status. OBJECTIVE To develop a QOL instrument specific to autoimmune bullous disease (AIBD). DESIGN A comprehensive item generation process was used to build a 45-item pilot Autoimmune Bullous Disease Quality of Life (ABQOL) questionnaire, distributed to 70 patients with AIBD. Experts in bullous disease refined the pilot ABQOL before factor analysis was performed to yield the final ABQOL questionnaire of 17 questions.We evaluated validity and reliability across a range of indices. SETTING Australian dermatology outpatient clinics and private dermatology practices. PATIENTS AND EXPOSURE Patients with a histological diagnosis of AIBD. MAIN OUTCOMES AND MEASURES The development of an AIBD-specific QOL instrument. RESULTS Face and content validity were established through the comprehensive patient interview process and expert review. In terms of convergent validity, the ABQOL was found to have a moderate correlation with scores on the Dermatology Life Quality Index (R = 0.63) and the General Health subscale of the 36-Item Short Form Health Survey (R = 0.69; P = .009) and low correlation with the Pemphigus Disease Area Index (R = 0.42) and Autoimmune Bullous Disease Skin Disorder Intensity Score (R = 0.48). In terms of discriminant validity, the ABQOL was found to be more sensitive than the Dermatology Life Quality Index (P = .02). The ABQOL was also found to be a reliable instrument evaluated by internal consistency (Cronbach α coefficient, 0.84) and test-retest reliability (mean percentage variation, 0.92). CONCLUSIONS AND RELEVANCE The ABQOL has been shown to be a valid and reliable instrument that may serve as an end point in clinical trials. Future work should include incorporating patient weighting on questions to further increase content validity and translation of the measure to other languages

Gaia16apd - A link between fast and slowly declining type I superluminous supernovae

We present ultraviolet (UV), optical and infrared photometry and optical spectroscopy of the type Ic superluminous supernova (SLSN) Gaia16apd (=SN 2016eay), covering its evolution from 26 d before the g-band peak to 234.1 d after the peak. Gaia16apd was followed as a part of the NOT Unbiased Transient Survey (NUTS). It is one of the closest SLSNe known (z = 0.102 ± 0.001), with detailed optical and UV observations covering the peak. Gaia16apd is a spectroscopically typical type Ic SLSN, exhibiting the characteristic blue early spectra with O II absorption, and reaches a peak Mg = -21.8 ± 0.1 mag. However, photometrically it exhibits an evolution intermediate between the fast and slowly declining type Ic SLSNe, with an early evolution closer to the fast-declining events. Together with LSQ12dlf, another SLSN with similar properties, it demonstrates a possible continuum between fast and slowly declining events. It is unusually UV-bright even for an SLSN, reaching a non-K-corrected Muvm2 ? -23.3 mag, the only other type Ic SLSN with similar UV brightness being SN 2010gx. Assuming that Gaia16apd was powered by magnetar spin-down, we derive a period of P = 1.9 ± 0.2 ms and a magnetic field of B = 1.9 ± 0.2 × 1014 G for the magnetar. The estimated ejecta mass is between 8 and 16 M?, and the kinetic energy between 1.3 and 2.5 × 1052 erg, depending on opacity and assuming that the entire ejecta is swept up into a thin shell. Despite the early photometric differences, the spectra at late times are similar to slowly declining type Ic SLSNe, implying that the two subclasses originate from similar progenitors. © 2017 The Authors.Villum Fonden Federación Española de Enfermedades Raras, FEDER: ESP2016-80079-C2-1-R, MDM-2014-0369, ESP2014-55996-C2-1-R AST-1008343, PRIN 2010-2011, AST-1613472 National Science Foundation, NSF: 1545949 Suomen Kulttuurirahasto 1994 PRIN-INAF 2014 Instituto de Ciencias del Cosmos, Universitat de Barcelona, ICCUB Ministry of Economy Infocomm Development Authority of Singapore, IDA: Danish Astronomy Emil Aaltosen Säätiö International Parkinson and Movement Disorder Society, MDS National Centre for Atmospheric Science, NCAS: OPUS 2015/17/B/ST9/03167 Københavns Universitet, KU Ministerio de Economía y Competitividad, MINECOWe thank the anonymous referee for comments that helped improve this paper considerably. We thank Subo Dong, Cosimo Inserra, Christa Gall, Peter Brown and Andrea Pastorello for their suggestions. We acknowledge ESA Gaia, DPAC and the Photometric Science Alerts Team (http://gsaweb.ast.cam.ac.uk/alerts). The pt5m and TJO preliminary photometric calibrations were obtained using the Cambridge Photometric Calibration Server (CPCS), designed and maintained by Sergey Koposov and Lukasz Wyrzykowski. Based on observations made with the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association, and with the Gran Telescopio Canarias (GTC), at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. The data presented here were obtained in part with ALFOSC,which is provided by the Instituto deAstrofisica de Andalucia (IAA) under a joint agreement with the University of Copenhagen and NOTSA. We also thank support astronomers working in Telescopi Joan Or? at Montsec Observatory (OAdM) for their help to run the needed sequences on time for our Gaia alert programme. TK acknowledges financial support by the Emil Aaltonen Foundation. NB was supported by the GROWTH project funded by the National Science Foundation under Grant No. 1545949. JH acknowledges support by the Finnish Cultural Foundation. MF acknowledges the support of a Royal Society-Science Foundation Ireland University Research Fellowship. NER acknowledges financial support by the 1994 PRIN-INAF 2014 (project 'Transient Universe: unveiling new types of stellar explosions with PESSTO') and by MIUR PRIN 2010-2011, 'The darkUniverse and the cosmic evolution of baryons: from current surveys to Euclid'. EYH acknowledges the support provided by the National Science Foundation under Grant No. AST-1008343 and AST-1613472. MDS is funded by generous support provided by the DanishAgency for Science and Technology and Innovation realized through a Sapere Aude Level 2 grant and a grant from the Villum Foundation. This work was supported by the MINECO (Spanish Ministry of Economy)-FEDER through grants ESP2016-80079-C2-1-R and ESP2014-55996-C2-1-R and MDM-2014-0369 of ICCUB (Unidad de Excelencia 'Mar?a de Maeztu'). NUTS is funded in part by the IDA (Instrument Centre for Danish Astronomy). LW was supported by Polish National Science Centre Grant No. OPUS 2015/17/B/ST9/03167. -