Gastric Extremely Well-Diferentiated Intestinal-Type Adenocarcinoma: A Challenging Lesion to Achieve Complete Endoscopic Resection

Extremely well-differentiated tubular adenocarcinomas (EWDAs) of the stomach are characterized by surface maturation and their mimicking of intestinal metaplasia. Endoscopically, intramucosal EWDAs are frequently ill defined with indistinct borders due to the pallor of the neoplastic mucosa and the lack of contrast against the background atrophic and metaplastic mucosa. We evaluated the effectiveness of endoscopic resection for EWDAs after endoscopic submucosal dissection (ESD). Among 872 patients with early gastric cancer, 17 EWDAs were identified (1.9 %). Endoscopically, the flat or depressed type was significantly more common among EWDAs (88.2 %) than among early gastric cancers of other histologies (37.8 %; P < 0.01). The discrepancy between endoscopically estimated tumor size and tumor size as confirmed in pathology reports was significantly greater among EWDAs (18.4 ± 22.0 mm) than among others (5.8 ± 7.5 mm). Involvement of the lateral resection margin was more common (29.4 % vs. 2.5 %; P < 0.05), and complete resection was achieved less often in EWDAs (47.1 % vs. 80.4 %; P = 0.01) compared to the others. EWDAs are associated with higher rates of incomplete resection after ESD, especially along the lateral margins. Pathologists should alert endoscopists when this diagnosis is made, with its associated risks; and endoscopists should pay particular attention to the extent of these tumors during resection

The rotation curves of dwarf galaxies: a problem for Cold Dark Matter?

We address the issue of accuracy in recovering density profiles from observations of rotation curves of galaxies. We ``observe'' and analyze our models in much the same way as observers do the real galaxies. We find that the tilted ring model analysis produces an underestimate of the central rotational velocity. In some cases the galaxy halo density profile seems to have a flat core, while in reality it does not. We identify three effects, which explain the systematic biases: (1) inclination (2), small bulge, and (3) bar. The presence of even a small non-rotating bulge component reduces the rotation velocity. In the case of a disk with a bar, the underestimate of the circular velocity is larger due to a combination of non-circular motions and random velocities. Signatures of bars can be difficult to detect in the surface brightness profiles of the model galaxies. The variation of inclination angle and isophote position angle with radius are more reliable indicators of bar presence than the surface brightness profiles. The systematic biases in the central ~ 1 kpc of galaxies are not large. Each effect separately gives typically a few kms error, but the effects add up. In some cases the error in circular velocity was a factor of two, but typically we get about 20 percent. The result is the false inference that the density profile of the halo flattens in the central parts. Our observations of real galaxies show that for a large fraction of galaxies the velocity of gas rotation (as measured by emission lines) is very close to the rotation of stellar component (as measured by absorption lines). This implies that the systematic effects discussed in this paper are also applicable both for the stars and emission-line gas.Comment: ApJ, in press, 30 pages, Latex, 21 .eps figure

Gas‐source molecular‐beam epitaxy using Si2H6 and GeH4 and x‐ray characterization of Si1−xGex (0≤x≤0.33) alloys

Gas‐source molecular‐beam epitaxy (MBE) has been used to grow SiGe alloys with Si2H6 and GeH4 as sources on (100) Si substrates. Single‐crystalline epilayers with Ge composition as high as 33% have been produced at 610 °C, the lowest temperature hitherto used for gas‐source SiGe MBE. Growth parameters, growth modes, and the structural characteristics have been studied by a variety of in situ and ex situ techniques. Double‐crystal x‐ray diffraction data for the alloys have been obtained for the first time in thin mismatched layers.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69862/2/JAPIAU-71-10-4916-1.pd

Decentralised Learning MACs for Collision-free Access in WLANs

By combining the features of CSMA and TDMA, fully decentralised WLAN MAC schemes have recently been proposed that converge to collision-free schedules. In this paper we describe a MAC with optimal long-run throughput that is almost decentralised. We then design two \changed{schemes} that are practically realisable, decentralised approximations of this optimal scheme and operate with different amounts of sensing information. We achieve this by (1) introducing learning algorithms that can substantially speed up convergence to collision free operation; (2) developing a decentralised schedule length adaptation scheme that provides long-run fair (uniform) access to the medium while maintaining collision-free access for arbitrary numbers of stations

The Intracluster Light and its Link with the Dynamical State of the Host Group/Cluster: the Role of the Halo Concentration

We investigate on the role of the halo concentration in the formation of the intra-cluster light (ICL) in galaxy groups and clusters, as predicted by a state-of-art semi-analytic model of galaxy formation, coupled with a set of high-resolution dark matter only simulations. The analysis focuses on how the fraction of ICL correlates with halo mass, concentration and fraction of early-type galaxies (ETGs) in a large sample of groups and clusters with $13.0\leq \log M_{halo} \leq 15.0$. The fraction of ICL follows a normal distribution, a consequence of the stochastic nature of the physical processes responsible for the formation of the diffuse light. The fractional budget of ICL depends on both halo mass (very weakly) until group scales, and concentration (remarkably). More interestingly, the ICL fraction is higher in more concentrated objects, a result of the stronger tidal forces acting in the innermost regions of the haloes where the concentration is the quantity playing the most relevant role. Our model predictions do not show any dependence between the ICL and ETGs fractions and so, we instead suggest the concentration rather than the mass, as recently claimed, to be the main driver of the ICL formation. The diffuse light starts to form in groups via stellar stripping and mergers and later assembled in more massive objects. However, the formation and assembly keep going on group/cluster scales at lower redshift through the same processes, mainly via stellar stripping in the vicinity of the central regions where tidal forces are stronger.Comment: 16 pages, 6 figures, 1 table. Accepted for publication in ApJ, small correction

Time--Splitting Schemes and Measure Source Terms for a Quasilinear Relaxing System

Several singular limits are investigated in the context of a $2 \times 2$ system arising for instance in the modeling of chromatographic processes. In particular, we focus on the case where the relaxation term and a $L^2$ projection operator are concentrated on a discrete lattice by means of Dirac measures. This formulation allows to study more easily some time-splitting numerical schemes

The Origin of the Brightest Cluster Galaxies

Most clusters and groups of galaxies contain a giant elliptical galaxy in their centres which far outshines and outweighs normal ellipticals. The origin of these brightest cluster galaxies is intimately related to the collapse and formation of the cluster. Using an N-body simulation of a cluster of galaxies in a hierarchical cosmological model, we show that galaxy merging naturally produces a massive, central galaxy with surface brightness and velocity dispersion profiles similar to observed BCG's. To enhance the resolution of the simulation, 100 dark halos at $z=2$ are replaced with self-consistent disk+bulge+halo galaxy models following a Tully-Fisher relation using 100000 particles for the 20 largest galaxies and 10000 particles for the remaining ones. This technique allows us to analyze the stellar and dark matter components independently. The central galaxy forms through the merger of several massive galaxies along a filament early in the cluster's history. Galactic cannibalism of smaller galaxies through dynamical friction over a Hubble time only accounts for a small fraction of the accreted mass. The galaxy is a flattened, triaxial object whose long axis aligns with the primordial filament and the long axis of the cluster galaxy distribution agreeing with observed trends for galaxy-cluster alignment.Comment: Revised and accepted in ApJ, 25 pages, 10 figures, online version available at http://www.cita.utoronto.ca/~dubinski/bcg

Two-Temperature Intracluster Medium in Merging Clusters of Galaxies

We investigate the evolution of intracluster medium during a cluster merger, explicitly considering the relaxation process between the ions and electrons by N-body and hydrodynamical simulations. When two subclusters collide each other, a bow shock is formed between the centers of two substructures and propagate in both directions along the collision axis. The shock primarily heats the ions because the kinetic energy of an ion entering the shock is larger than that of an electron by the ratio of masses. In the post-shock region the energy is transported from the ions to electrons via Coulomb coupling. However, since the energy exchange timescale depends both on the gas density and temperature, distribution of electron temperature becomes more complex than that of the plasma mean temperature, especially in the expanding phase. After the collision of two subclusters, gas outflow occurs not only along the collision axis but also in its perpendicular direction. The gas which is originally located in the central part of the subclusters moves both in the parallel and perpendicular directions. Since the equilibrium timescale of the gas along these directions is relatively short, temperature difference between ions and electrons is larger in the directions tilted by the angles of $\pm 45^\circ$ with respect to the collision axis. The electron temperature could be significantly lower that the plasma mean temperature by $\sim 50$ at most. The significance of our results in the interpretation of X-ray observations is briefly discussed.Comment: 20 pages, 11 figures, Accepted for publication in Ap