The Reliability and Validity of Persian Translation of the Seattle Angina Questionnaire in Patients with Myocardial Infarction

AbstractIntroduction: Myocardial Infarction (MI) is the major cause of death in the industrial countries. In addition to the clinical and economic burden, MI affects health related quality of life (HRQoL). Original version of the SAQ was developed cross-sectionally and may be used for measuring clinically important dimensions of coronary artery disease. However, the Persian translation is not available for Myocardial Infarction patients. Materials and Methods: After multi-stage translating based on Manufacturers Alliance for Productivity and Innovation (MAPI) protocol, the reliability examined on 130 patients with MI. The SF-36 was used to assess the validity of the SAQ. To assess test-retest reliability, the patients refilled the SAQ after 5 days. Results: Reliability of the SAQ was assessed by Cronbach’s Alpha and the Intra-class Correlation Coefficient (ICC). Validity was determined using Pearson correlation matrix for the subclasses and the total scores (ρ). ICC exceeded 0.6 in all domains. The weighted kappa ranged from 0.492 to 0.853. Conclusion: Reliability and validity of the Persian version of the SAQ is acceptable and seems that this questionnaire can be a useful tool in assessing health related quality of life in Persian speaking patients with myocardial infarction suffering from angina. Keywords: Seattle Angina Questionnaire (SAQ), myocardial infarction, health related quality of life, reliability, validit

Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

Abstarct Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate the association between glaucoma and other neurodegenerative disorders by investigating glaucoma-associated protein changes in the retina and vitreous humour. The multiplexed Tandem Mass Tag based proteomics (TMT-MS3) was carried out on retinal tissue and vitreous humour fluid collected from glaucoma patients and age-matched controls followed by functional pathway and protein network interaction analysis. About 5000 proteins were quantified from retinal tissue and vitreous fluid of glaucoma and control eyes. Of the differentially regulated proteins, 122 were found linked with pathophysiology of Alzheimer’s disease (AD). Pathway analyses of differentially regulated proteins indicate defects in mitochondrial oxidative phosphorylation machinery. The classical complement pathway associated proteins were activated in the glaucoma samples suggesting an innate inflammatory response. The majority of common differentially regulated proteins in both tissues were members of functional protein networks associated brain changes in AD and other chronic degenerative conditions. Identification of previously reported and novel pathways in glaucoma that overlap with other CNS neurodegenerative disorders promises to provide renewed understanding of the aetiology and pathogenesis of age related neurodegenerative diseases