OPTIMIZACIJA PROIZVODNJE STRONCIJEVIH SPOJEVA POMOĆU UZORKA CELESTINSKE RUDE

The direct conversion of celestine (SrSO4) to strontium carbonate as well as its enrichment by hydrometallurgy were investigated. A study was also conducted to investigate whether acid concentration affected the quality of strontium sulfate in celestine concentrates. Based on the results of a laboratory assay, it was determined that 98.04% SrSO4 was leached optimally under agitation. The ground sample of celestine concentrate was then leached by agitation for three hours after the dimensional analysis had determined the appropriate grinding time. To determine the optimal approach for the agitated leaching of strontium carbonate, different approaches were tested. Various factors, including temperature, return water, solid percentage, and sodium carbonate to strontium sulfate ratio, were studied. At 90°C, celestine completely converts into strontium carbonate with a solid percentage of 20% and a sodium carbonate to strontium sulfate ratio of 4:5. As part of the investigation into the possibility of producing strontium oxide, samples of celestine concentrate and strontium carbonate produced under optimal conditions were heated at 500 and 1000°C to determine which phase would form the oxidized phase. An X-ray analysis indicates that the oxidation phase forms at a temperature of more than 750°C.U radu se istražuje izravna pretvorba celestina (SrSO4) u stroncijev karbonat i njegovo obogaćivanje hidrometalurgijskim postupcima. Također, provedeno je istraživanje o utjecaju koncentracije kiseline na kvalitetu stroncijeva sulfata u koncentratima celestina. Na temelju rezultata laboratorijskih ispitivanja utvrđeno je da se 98,04 % SrSO4 optimalno izlužuje uz miješanje. Nakon što je dimenzijskom analizom određeno odgovarajuće vrijeme mljevenja, samljeveni uzorak koncentrata celestina izlužen je protresanjem tijekom tri sata. Testirani su različiti pristupi kako bi se odredio optimalan postupak za izluživanje uz protresanje stroncijeva karbonata. Proučavani su različiti čimbenici, uključujući temperaturu, povratnu vodu, postotak čvrste tvari i omjer natrijeva karbonata i stroncijeva sulfata. Na 90 °C celestin se potpuno pretvara u stroncijev karbonat s 20 % udjela čvrste tvari i omjerom natrijeva karbonata i stroncijeva sulfata od 4 : 5. Kako bi se utvrdilo koja će faza tvoriti oksidiranu fazu u sklopu istraživanja mogućnosti proizvodnje stroncijeva oksida, uzorci koncentrata celestina i stroncijeva karbonata načinjeni su u optimalnim uvjetima zagrijavanjem na 500 i 1000 °C. Rendgenska analiza pokazuje da se oksidacijska faza formira na temperaturi višoj od 750 °C

CRC-ICM: Colorectal Cancer Immune Cell Markers Pattern Dataset

Colorectal Cancer (CRC) is the second most common cause of cancer death in the world, ad can be identified by the location of the primary tumor in the large intestine: right and left colon, and rectum. Based on the location, CRC shows differences in chromosomal and molecular characteristics, microbiomes incidence, pathogenesis, and outcome. It has been shown that tumors on left and right sides also have different immune landscape, so the prognosis may be different based on the primary tumor locations. It is widely accepted that immune components of the tumor microenvironment (TME) plays a critical role in tumor development. One of the critical regulatory molecules in the TME is immune checkpoints that as the gatekeepers of immune responses regulate the infiltrated immune cell functions. Inhibitory immune checkpoints such as PD-1, Tim3, and LAG3, as the main mechanism of immune suppression in TME overexpressed and result in further development of the tumor. The images of this dataset have been taken from colon tissues of patients with CRC, stained with specific antibodies for CD3, CD8, CD45RO, PD-1, LAG3 and Tim3. The name of this dataset is CRC-ICM and contains 1756 images related to 136 patients. The initial version of CRC-ICM is published on Elsevier Mendeley dataset portal, and the latest version is accessible via: https://databiox.co

Assessment the relation between lifestyle with mental health and educational achievement in nursing students

Objective: This study was aimed to assess the correlation between lifestyle with mental health and educational achievement of nursing students. Materials and Methods: This is a descriptive-correlational study that all students in nursing college in 2015 were selected by the census sampling method. Data gathering tool were standard Walker's lifestyle questionnaire and General Health Questionnaire-28 and data were analyzed by SPSS/21. Results: The results reported that most subjects (61.01%) displayed moderate levels of lifestyle. In considering domains mental health 37.28%, were depression and 34.74% anxiety. Based on the Pearson correlation coefficient test, there was a diverse correlation between lifestyle (p=0.004, r=-0.34) and educational achievement (p=0.001, r=-0.24) with mental health but there was a direct linear correlation between lifestyle and educational achievement. Conclusion: Regarding the role of lifestyle and mental health and to ensure the efficiency and dynamism of the people in the education and prevention of academic failure recommended that be scheduled by improve methods of lifestyle to promote educational status and activate counseling centers and guidance on psychological issues the mental health. Keywords Author Keywords:lifestyle; mental health; educational achievement; students KeyWords Plus:QUALITY-OF-LIFE; ACADEMIC-PERFORMANCE; CANCE

Investigating the Effects of Land Use Changes on Dust Storms in the Sistan Region Using Markov Chain Forecasting

IntroductionPopulation growth and the excessive use of natural resources have caused significant changes in natural ecosystems, including a decrease in rainfall and an increase in temperature. The potential exists for them to decrease vegetation and increase barren areas. Serious economic, social, and environmental damage can occur in natural ecosystems due to the destruction of land cover and other damages, such as dust storms. Therefore, ecosystem changes are taking place worldwide, both at the temporal and spatial scale, due to human activities and natural factors. So, investigating the amount of land use/cover changes, their effect on dust storms, and predicting these changes for the coming years can be an important step in reducing and controlling unprincipled changes, planning, and optimizing resource. Climate change and human activities, such as drought, human activities, and non-compliance with water rights, have a significant impact on the Hamon wetland area, so that the dry bed of the wetland has become the main sources of dust. This research is focused on investigating the impact of land use changes on dust storms and forecasting land use changes in the Sistan region for the next 20 years. Material and MethodsThe impact of land use changes on dust storms in the Sistan region was examined using Markov chain forecasting methods. For this purpose, first of all, the land use maps of 2002, 2011 and 2022 were prepared using satellite images. An anomalous method was used to investigate climatic parameters, including temperature, rainfall, and the number of days with dust, in the next step. To evaluate climatic changes, it is necessary to use a method that shows long-term changes. The anomaly method was employed for this purpose. The values of this index can be either positiveor negative. In order to predict land use changes for the next 20 years, the combination of the maps of 2002 and 2022 for severe drought conditions were used by using Markov chain and Cell models. The Markov model was predicted to generate multiple images. The transfer probability matrix allows for the expression of the probability that any type of land cover will be found in any location in the future. Despite the accuracy of transmission probabilities for each user is unknown, due to the lack of information on the spatial distribution of users, the Markov model does not have any spatial dependence information.  In contrast, to the automatic network, it is an agent that has the ability to change its state based on the application of the law that shows the new state in accordance with the previous state and the state of its neighbors. Results and DiscussionThis study examined the impact of land use change on dust in the Sistan region. At first, climatic changes of temperature, rainfall and number of dusty days were investigated and the results showed that the temperature has increased and rainfall has decreased in the Sistan region during the last two decades. The land use maps also showed that in the years when the Hamon wetland has been drained, pastures and dense vegetation have increased and barren lands and salt marshes have decreased. But due to the recent droughts like the year 2022, when a drought has occurred in the region, the use of vegetation and pasture has decreased and barren and salt marshes have increased. These conditions cause an increase in the level of dust in the region. The land use map for severe drought conditions in the next 20 years was predicted using the Markov model.  It showed that in the future, pastures and dense vegetation will decrease, but barren lands and salt marsh areas will increase dramatically. As desertification and wind erosion increase, dust storms will also increase as a result of these conditions. The economic, social, environmental, and health conditions of residents in the region are adversely affected by dust storms. Therefore, proper planning and management can reduce the damages caused by dust storms in the Sistan region

Optimization of Aflatoxin B1 Aptasensing

Combination of aptamers with DNAzymes attracted intense attention for development of DNA-based biosensors for detection of mycotoxins. In the present study a combination of aflatoxin B1 specific aptamer and HRP- (horseradish peroxidase-) mimicking DNAzyme was optimized for detecting aflatoxin B1. Detecting approach is based on the binding affinity of aflatoxin B1 to its specific aptamer and conversion of substrate to a detectable colorimetric signal by a linked DNAzyme. Compared to conventional methods for aflatoxin B1 detection, DNA-based assay has the advantages of low cost, long-term stability, and rapid, simple, and user-friendly steps

Different Cytotoxic Effects of Caper from Different Geographical Regions May Be Related to Changes in Mitochondrial Sirt3

Background and objectives: Beside its nutritional role, caper (Capparis spinosa) has long been used as an analgesic, anti-inflammatory, anti-diabetic and anti-cancer remedy. In the present study, we tested whether this plant can make effective changes in Sirt3 and mitochondrial function in colorectal carcinoma cell line since mitochondrial dysfunction has long been implicated in both cancer and diabetes and benefit confers by caper in these diseases might be due to mitochondrial alterations. Methods: Total flavonoids and phenolics were assayed using colorimetric tests. Cytotoxicity of a phenolic-flavonoid rich extract of caper collected from two different geographical regions (south and west) were mechanistically studied in HT-29 cell line. Activity of an essential mitochondrial enzyme, Sirt3 has also been evaluated along with other parameters. IC50 of extracts were determined by MTT cytotoxicity assay, cell death and mitochondrial membrane potential were evaluated via flow cytometric analysis. Also, at IC50 concentrations, Sirt3 activity was determined fluorimetrically. Results: The results showed that caper induced significant cytotoxicity in HT-29 cells followed by mitochondrial membrane potential collapse, ROS overproduction, Sirt3 activity alteration and cell death. Conclusions: The above-mentioned cytotoxic parameters were inversely proportional to the phenolic and flavonoid contents of the extract showing that other mechanisms beyond their antioxidant capacities may contribute to their anti-cancer effects. In other term, these results suggest that antioxidant capacity may not directly contribute to the anticancer property

Adenoid Hyperplasia in a Patient With a Rare Type of Hyper Immunoglobulin M Syndrome Due to CD40 Deficiency

CD40 deficiency yield to an autosomal recessive subtype of hyper-immunoglobulin M syndrome (HGIM type 3), presenting with an almost identical clinical picture to X-linked CD40L deficiency (HIGM type 1) with profound T-cell dysfunction yielding to opportunistic infections as well as neutropenia, autoimmunity, and malignancy. We presented a girl with recurrent upper respiratory tract infections and lymphoid hyperplasia which was diagnosed with type 3 hyper IgM syndrome due to CD40 gene mutation. Otitis media with opportunistic germs and no evidence for an X-linked pattern of inheritance were diagnostic keys to type 3 hyper IgM syndrome in our patient

Potential Molecular Mechanisms of Bisphenol A in Obesity Development

Bisphenol A (BPA), an endocrine disruptor, is associated with metabolic disorders. However, several studies have suggested that exposure to BPA can cause obesity. It has recently got more attention from scientists as a risk factor for obesity due to its ability to mimic natural estrogens and bind to their receptors. Nonetheless, the molecular mechanism underpinning the environmental etiology of metabolic disorders has not been not fully clarified. In this regard, BPA exposure directly disrupts endocrine regulation, neuroimmune and signaling pathways, and gut microbes, resulting in obesity. In addition, epidemiological studies have revealed a significant relationship between BPA exposure and the development of obesity, although conflicting results have been reported. Therefore, this review summarized the possible role and molecular mechanisms associated with BPA exposure that may lead to obesity based on in vivo and in vivo studies

Atypical Ataxia Presentation in Variant Ataxia Telangiectasia: Iranian Case-Series and Review of the Literature

Ataxia-telangiectasia (AT) is a rare autosomal recessive neurodegenerative multisystem disorder. A minority of AT patients can present late-onset atypical presentations due to unknown mechanisms. The demographic, clinical, immunological and genetic data were collected by direct interview and examining the Iranian AT patients with late-onset manifestations. We also conducted a systematic literature review for reported atypical AT patients. We identified three Iranian AT patients (3/249, 1.2% of total registry) with later age at ataxia onset and slower neurologic progression despite elevated alpha-fetoprotein levels, history of respiratory infections, and immunological features of the syndrome. Of note, all patients developed autoimmunity in which a decrease of naïve T cells and regulatory T cells were observed. The literature searches also summarized data from 73 variant AT patients with atypical presentation indicating biallelic mild mutations mainly lead to an atypical phenotype with an increased risk of cancer. Variant AT patients present with milder phenotype or atypical form of classical symptoms causing under- or mis- diagnosis. Although missense mutations are more frequent, an atypical presentation can be associated with deleterious mutations due to unknown modifying factors