5 research outputs found
The expression of CD markers in solid tumors: Significance in metastasis and prognostic value
Objective. The clusters of differentiations
(CDs) are among the surface markers expressed on
different cells in the body, which are involved in the
communication of cells with each other and the
induction of signaling. Moreover, the evaluation of the
ectopic expression of these markers in solid tumors has
led to the detection of disease in early stages. In this
paper, we have examined the effect of CD markers
expression on the function of cancer cells, as well as
their importance as the diagnostic and prognostic factors
for monitoring the progression of solid tumors. Materials
and methods Relevant literature was identified by a
PubMed search (1988-2017) of English the language
papers using the terms “CD markers”, “diagnostic”,
“prognostic”, “predictive marker” and “solid tumors.”
Discussion. Finally, it can be stated that the evaluation of
CDs is not only of diagnostic value at disease onset, but
these markers can be used as prognostic and predictive
markers to contribute to the treatment of disease and
predict its relapse. Conclusion. Monitoring of tumors
progression through CDs expressed on circulating tumor
cells could be a new diagnostic and prognostic factor in
the future
Bone marrow blood vessels: normal and neoplastic niche
Blood vessels are among the most important factors in the transport of materials such as nutrients and oxygen. This study will review the role of blood vessels in normal bone marrow hematopoiesis as well as pathological conditions like leukemia and metastasis. Relevant literature was identified by a Pubmed search (1992-2016) of English-language papers using the terms bone marrow, leukemia, metastasis, and vessel. Given that blood vessels are conduits for the transfer of nutrients, they create a favorable situation for cancer cells and cause their growth and development. On the other hand, blood vessels protect leukemia cells against chemotherapy drugs. Finally, it may be concluded that the vessels are an important factor in the development of malignant diseases