Synthesis and Use of Silica Xerogels Doped with Iron as a Photocatalyst to Pharmaceuticals Degradation in Water

The main objective of this study was to assess the photoactive properties of iron-doped silica xerogels under solar radiation. For this purpose, silica xerogels (XGS) synthesized by the sol-gel method were doped with Fe (III) by two routes: impregnation and polymerization. XGS samples were texturally and chemically characterized by N2 adsorption, XRD, FTIR, Raman, SEM-EDX, DRS, and PL, evidencing the suitability of using XGS substrates to host iron clusters on their surface with total compatibility. Chlorphenamine (CPM), ciprofloxacin (CIP), and ranitidine (RNT) were used as model compounds. The degradation of the molecules was made under simulated solar radiation testing the synthesis pad, load, material size, and reuse. It was found that XGS doped with Fe by the impregnation route (XGS-Fe-Im) were able to completely degrade CPM and RNT in 30 min and 10 min, respectively, whilst for CIP it achieved the removal of 60% after 1 h of solar radiation exposure, outperforming parent materials and solar radiation by itself. The study of the degradation mechanism elucidated a major influence from the action of HO radicals. The present investigation offers a potential route of application of XGS Fe-doped materials for the removal of emerging concern contaminants under near real-world conditions.Junta de AndaluciaEuropean CommissionSpanish Government P18-RT-4193Consejo Nacional de Ciencia y Tecnologia (CONACyT) CVU 4921

Ciprofloxacin, ranitidine, and chlorphenamine removal from aqueous solution by adsorption. Mechanistic and regeneration analysis.

This work was supported by Consejo Nacional de Ciencia y Tecnología, for the schoolarship CVU49215Several studies have reported the presence of pharmaceuticals in freshwater bodies all around the world. For this investigation, the removal of the pharmaceuticals ciprofloxacin (CIP) ranitidine (RNT), and chlorphenamine (CPM) using lignocellulose-derived granular activated carbon (GAC) was analyzed, and the physicochemical mechanisms of removal were elucidated. Additionally, the textural and surface properties of the GAC were evaluated, the concentrations of the contaminants were monitored with UV–Vis Spectrophotometry. The results revealed that GAC is a mesoporous material with a surface area of 940 m2/g and an acidic character with a point of zero charge (pH PZC) around 2. The adsorption isotherms showed a consistent behavior with the Prausnitz–Radke model, reporting adsorption capacities of 668, 521, and 582μmol/g (221, 173 and 193 mg/g), at an equilibrium concentration of 50μmol/L, pH 7 and 25 °C for CIP, RNT and CPM, respectively. Moreover, studies at different pH levels, temperature, and reversibility suggested that adsorption obeys physical mechanisms, which led to the proposal of a chemical regeneration process with organic (ethanol and methanol) and inorganic (NaOH and HCl) diluents. Better results were obtained using the inorganic diluents, ranging between 44 and 73% thermodynamic desorption. Additionally, three reuse cycles were successfully performed at the best conditions, with a regeneration efficiency in the range of 68%–98% for each of the pharmaceuticals. The results demonstrate the viability of the use of GAC for the removal of drugs with different characteristics in scenarios that are very close to the real ones.Consejo Nacional de Ciencia y Tecnología CVU4921

Remediación de efluentes acuosos contaminados con fármacos mediante procesos de adsorción y fotoquímicos

Tesis Univ. Granada

Synthesis and Use of Silica Xerogels Doped with Iron as a Photocatalyst to Pharmaceuticals Degradation in Water

The main objective of this study was to assess the photoactive properties of iron-doped silica xerogels under solar radiation. For this purpose, silica xerogels (XGS) synthesized by the sol-gel method were doped with Fe (III) by two routes: impregnation and polymerization. XGS samples were texturally and chemically characterized by N2 adsorption, XRD, FTIR, Raman, SEM-EDX, DRS, and PL, evidencing the suitability of using XGS substrates to host iron clusters on their surface with total compatibility. Chlorphenamine (CPM), ciprofloxacin (CIP), and ranitidine (RNT) were used as model compounds. The degradation of the molecules was made under simulated solar radiation testing the synthesis pad, load, material size, and reuse. It was found that XGS doped with Fe by the impregnation route (XGS-Fe-Im) were able to completely degrade CPM and RNT in 30 min and 10 min, respectively, whilst for CIP it achieved the removal of 60% after 1 h of solar radiation exposure, outperforming parent materials and solar radiation by itself. The study of the degradation mechanism elucidated a major influence from the action of HO• radicals. The present investigation offers a potential route of application of XGS Fe-doped materials for the removal of emerging concern contaminants under near real-world conditions

Synthesis and Use of Silica Xerogels Doped with Iron as a Photocatalyst to Pharmaceuticals Degradation in Water

The main objective of this study was to assess the photoactive properties of iron-doped silica xerogels under solar radiation. For this purpose, silica xerogels (XGS) synthesized by the sol-gel method were doped with Fe (III) by two routes: impregnation and polymerization. XGS samples were texturally and chemically characterized by N2 adsorption, XRD, FTIR, Raman, SEM-EDX, DRS, and PL, evidencing the suitability of using XGS substrates to host iron clusters on their surface with total compatibility. Chlorphenamine (CPM), ciprofloxacin (CIP), and ranitidine (RNT) were used as model compounds. The degradation of the molecules was made under simulated solar radiation testing the synthesis pad, load, material size, and reuse. It was found that XGS doped with Fe by the impregnation route (XGS-Fe-Im) were able to completely degrade CPM and RNT in 30 min and 10 min, respectively, whilst for CIP it achieved the removal of 60% after 1 h of solar radiation exposure, outperforming parent materials and solar radiation by itself. The study of the degradation mechanism elucidated a major influence from the action of HO• radicals. The present investigation offers a potential route of application of XGS Fe-doped materials for the removal of emerging concern contaminants under near real-world conditions

ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin

The use of nanomaterials for the controlled release of drugs aims to enhance their effectiveness, especially when poorly soluble in water, and achieve their rapid, localized, and effective administration. The present study focuses on the use of a Zeolitic Imidazolate Framework-8 (ZIF-8) as vehicle for the transport and controlled release of the antibiotic ciprofloxacin (CIP) as model due to its favorable physicochemical characteristics. The objective is to synthesize the ZIF-8 material loaded with CIP through encapsulation for subsequent release of the drug in neutral and acid physiological media. In addition, functionalization of the CIP/ZIF compound with magnetic nanoparticles (NP) was sought to increase its traceability through the possible use of magnetic fields. Characterizations by XRD, FT-IR, SEM-EDX, and TGA showed a satisfactory synthesis of both pure ZIF-8 and ciprofloxacin-loaded ZIF-8, with high crystallinity and thermal stability. The release profiles showed an abrupt initial release that stabilized over time. A much higher release (20–80% greater) was obtained in acid versus neutral pH in all cases, attributable to the collapse of the ZIF-8 structure in acid media. In addition, functionalization of the material with iron NPs did not affect the behavior of the system during drug release. Antimicrobial activity tests against E. coli and S. aureus showed that ZIF-8 per se exerts antimicrobial activity, while the compounds CIP/ZIF and magnetic CIP/ZIF increased the antimicrobial capacity of pure CIP by 10–20%. The ZIF-8 system has high potential as a drug carrier and release agent for the treatment of diseases, especially those that cause acidification of the cellular environment, achieving a rapid, localized, and targeted action with the possibility of achieving traceability of the system after its magnetic functionalization.P18-RT-419

Mis casos Clínicos de Odontopediatría y Ortodoncia

Libro que conjunta casos en el área de Odontopediatría y OrtodonciaEs para los integrantes de la Red de Investigación en Estomatología (RIE) una enorme alegría presentar el tercer libro del 2021, sobre casos clínicos, revisiones de la literatura e investigaciones. La RIE está integrada por cuerpos académicos de la UAEH, UAEM, UAC y UdeG