Misoprostol versus Placebo for Unsatisfactory Colposcopic Finding: A Randomized Controlled Trial

Objective: To assess the effectiveness of vaginal misoprostol for converting unsatisfactory to satisfactory colposcopy.Materials and Methods: Forty women with abnormal cervical cytology and unsatisfactory colposcopy who underwent colposcopic examination at colposcopic clinic Khon Kaen Hospital, between May, 2009 and June, 2010. Patients were randomly allocated to received either 200 μg misoprostol or placebo vaginally, and colposcopic examination were taken 4 hours later. The percentage of conversion to satisfaction result and the adverse effects were recorded.Result: There were 20 women in each misoprostol and placebo group. One patient was excluded from each group because of follow up problem. In misoprostol group, 13 out of 19 patients (68.4%) were converted into satisfactory colposcopy result compared with five out of 19 patients (26.3%) in placebo group. This effect was statistically significant difference (P=0.009). No serious adverse effects was reported in both groups. Conclusions: Two hundred micrograms of vaginal misoprostol was effective and safe to convert unsatisfactory to satisfactory colposcopy result

Membrane Stripping to Reduce Postdate Pregnancy: A Randomized Controlled Trial

Objectives: To compare delivery before 40 weeks of gestation between the pregnant women who had membrane stripping and those with no intervention.Materials and Methods: One hundred and seventy-eight pregnant women, gestational age of 38 weeks or more who attended antenatal care clinic at Khon Kaen Hospital from January to July, 2016 were randomized into two groups: membrane stripping group and no intervention group. The proportion of pregnant women who delivered before 40 weeks of gestation was analyzed.Results: Baseline characteristics were similar between groups. The proportion of women who delivered before 40 weeks of gestation in membrane stripping group was significantly higher than no intervention group (69.3% VS 51.1%, p=0.01) (RR=0.6, 95% CI 0.4-0.9). There was no significant difference in cesarean section rate, maternal complications and neonatal outcomes between groups.Conclusion: Membrane stripping can reduce postdate pregnancy