Mechanical stress states in heterogeneous, wound rolls

This paper presents a method of predicting the internal stress states in rolls simultaneously wound with independent supply spools of dissimilar material. The method is based on linear, orthotropic behavior of the mandrel and web materials, and is sufficiently general to allow an arbitrary choice for web materials and their respective winding tensions. The generality of the method also permits the introduction and termination of additional webs of arbitrary material at any time during the winding process. The method is analytical, and utilizes an elasticity solution with rigorous satisfaction of boundary conditions between each ply of the wound roll. A prototypical wound capacitor is used as an example to provide for numerical results of the internal stress states induced during the winding process. Differences in the winding tension loss of the two dissimilar web materials is discussed and explained, as are other mechanical threats to roll stability and performance. The influence of winding tension variations on internal, wound stress states is also discussed

Running Gauge Coupling in Asymptotically Safe Quantum Gravity

We investigate the non-perturbative renormalization group behavior of the gauge coupling constant using a truncated form of the functional flow equation for the effective average action of the Yang-Mills-gravity system. We find a non-zero quantum gravity correction to the standard Yang-Mills beta function which has the same sign as the gauge boson contribution. Our results fit into the picture according to which Quantum Einstein Gravity (QEG) is asymptotically safe, with a vanishing gauge coupling constant at the non-trivial fixed point.Comment: 27 page

Top Partner Discovery in the T→tZT\to tZ channel at the LHC

In this paper we study the discovery potential of the LHC run II for heavy vector-like top quarks in the decay channel to a top and a $Z$ boson. Despite the usually smaller branching ratio compared to charged-current decays, this channel is rather clean and allows for a complete mass reconstruction of the heavy top. The latter is achieved in the leptonic decay channel of the $Z$ boson and in the fully hadronic top channel using boosted jet and jet substructure techniques. To be as model-independent as possible, a simplified model approach with only two free parameters has been applied. The results are presented in terms of parameter space regions for $3\sigma$ evidence or $5\sigma$ discovery for such new states in that channel.Comment: 24 pages, 8 figures, version 2 updated to JHEP 01 (2015) 08

Role of quantitative p16(INK4A) mRNA assay and digital reading of p16(INK4A) immunostained sections in diagnosis of cervical intraepithelial neoplasia

Cancer Research UK programme grant. Grant Number: C569/A1040

A Finite Quantum Gravity Field Theory Model

We discuss the quantization of Delta gravity, a two symmetric tensors model of gravity. This model, in Cosmology, shows accelerated expansion without a cosmological constant. We present the $\tilde{\delta}$ transformation which defines the geometry of the model. Then we show that all delta type models live at one loop only. We apply this to General Relativity and we calculate the one loop divergent part of the Effective Action showing its null contribution in vacuum, implying a finite model. Then we proceed to study the existence of ghosts in the model. Finally, we study the form of the finite quantum corrections to the classical action of the model.Comment: Latex, 33 page

Temporal Registration in In-Utero Volumetric MRI Time Series

We present a robust method to correct for motion and deformations in in-utero volumetric MRI time series. Spatio-temporal analysis of dynamic MRI requires robust alignment across time in the presence of substantial and unpredictable motion. We make a Markov assumption on the nature of deformations to take advantage of the temporal structure in the image data. Forward message passing in the corresponding hidden Markov model (HMM) yields an estimation algorithm that only has to account for relatively small motion between consecutive frames. We demonstrate the utility of the temporal model by showing that its use improves the accuracy of the segmentation propagation through temporal registration. Our results suggest that the proposed model captures accurately the temporal dynamics of deformations in in-utero MRI time series.National Institutes of Health (U.S.) (NIH NIBIB NAC P41EB015902)National Institutes of Health (U.S.) (NIH NICHD U01HD087211)National Institutes of Health (U.S.) (NIH NIBIB R01EB017337)Wistron CorporationMerrill Lynch Wealth Management (Fellowship

Temporal Registration in In-Utero Volumetric MRI Time Series

We present a robust method to correct for motion and deformations in in-utero volumetric MRI time series. Spatio-temporal analysis of dynamic MRI requires robust alignment across time in the presence of substantial and unpredictable motion. We make a Markov assumption on the nature of deformations to take advantage of the temporal structure in the image data. Forward message passing in the corresponding hidden Markov model (HMM) yields an estimation algorithm that only has to account for relatively small motion between consecutive frames. We demonstrate the utility of the temporal model by showing that its use improves the accuracy of the segmentation propagation through temporal registration. Our results suggest that the proposed model captures accurately the temporal dynamics of deformations in in-utero MRI time series.National Institutes of Health (U.S.) (NIH NIBIB NAC P41EB015902)National Institutes of Health (U.S.) (NIH NICHD U01HD087211)National Institutes of Health (U.S.) (NIH NIBIB R01EB017337)Wistron CorporationMerrill Lynch Wealth Management (Fellowship

Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries

The nuclear topography of splicing snRNPs, mRNA transcripts and chromosome domains in various mammalian cell types are described. The visualization of splicing snRNPs, defined by the Sm antigen, and coiled bodies, revealed distinctly different distribution patterns in these cell types. Heat shock experiments confirmed that the distribution patterns also depend on physiological parameters. Using a combination of fluorescencein situ hybridization and immunodetection protocols, individual chromosome domains were visualized simultaneously with the Sm antigen or the transcript of an integrated human papilloma virus genome. Three-dimensional analysis of fluorescence-stained target regions was performed by confocal laser scanning microscopy. RNA transcripts and components of the splicing machinery were found to be generally excluded from the interior of the territories occupied by the individual chromosomes. Based on these findings we present a model for the functional compartmentalization of the cell nucleus. According to this model the space between chromosome domains, including the surface areas of these domains, defines a three-dimensional network-like compartment, termed the interchromosome domain (ICD) compartment, in which transcription and splicing of mRNA occurs

Inflation and quintessence with nonminimal coupling

The nonminimal coupling (NMC) of the scalar field to the Ricci curvature is unavoidable in many cosmological scenarios. Inflation and quintessence models based on nonminimally coupled scalar fields are studied, with particular attention to the balance between the scalar potential and the NMC term in the action. NMC makes acceleration of the universe harder to achieve for the usual potentials, but it is beneficial in obtaining cosmic acceleration with unusual potentials. The slow-roll approximation with NMC, conformal transformation techniques, and other aspects of the physics of NMC are clarified.Comment: 36 pages, LaTeX. Typos in Eq. (2.5) correcte