Debris and micrometeorite impact measurements in the laboratory

A method was developed to simulate space debris in the laboratory. This method, which is an outgrowth of research in inertial confinement fusion (ICF), uses laser ablation to accelerate material. Using this method, single 60 micron aluminum spheres were accelerated to 15 km/sec and larger 500 micron aluminum spheres were accelerated to 2 km/sec. Also, many small (less than 10 micron diameter) irregularly shaped particles were accelerated to speeds of 100 km/sec

About Gravitomagnetism

The gravitomagnetic field is the force exerted by a moving body on the basis of the intriguing interplay between geometry and dynamics which is the analog to the magnetic field of a moving charged body in electromagnetism. The existence of such a field has been demonstrated based on special relativity approach and also by special relativity plus the gravitational time dilation for two different cases, a moving infinite line and a uniformly moving point mass, respectively. We treat these two approaches when the applied cases are switched while appropriate key points are employed. Thus, we demonstrate that the strength of the resulted gravitomagnetic field in the latter approach is twice the former. Then, we also discuss the full linearized general relativity and show that it should give the same strength for gravitomagnetic field as the latter approach. Hence, through an exact analogy with the electrodynamic equations, we present an argument in order to indicate the best definition amongst those considered in this issue in the literature. Finally, we investigate the gravitomagnetic effects and consequences of different definitions on the geodesic equation including the second order approximation terms.Comment: 16 pages, a few amendments have been performed and a new section has been adde

Derivation of the Planck Spectrum for Relativistic Classical Scalar Radiation from Thermal Equilibrium in an Accelerating Frame

The Planck spectrum of thermal scalar radiation is derived suggestively within classical physics by the use of an accelerating coordinate frame. The derivation has an analogue in Boltzmann's derivation of the Maxwell velocity distribution for thermal particle velocities by considering the thermal equilibrium of noninteracting particles in a uniform gravitational field. For the case of radiation, the gravitational field is provided by the acceleration of a Rindler frame through Minkowski spacetime. Classical zero-point radiation and relativistic physics enter in an essential way in the derivation which is based upon the behavior of free radiation fields and the assumption that the field correlation functions contain but a single correlation time in thermal equilibrium. The work has connections with the thermal effects of acceleration found in relativistic quantum field theory.Comment: 23 page

Dynamics and Statics of Nonaxisymmetric Liquid Bridges

Theoretical and experimental investigation of the stability of nonaxisymmetric and nonaxisymmetric bridges contained between equal and unequal radii disks as a function of Bond and Weber number with emphasis on the transition from unstable axisymmetric to stable nonaxisymmetric shapes, are conducted. Numerical analysis of the stability of nonaxisymmetric bridges between unequal disks for various orientations of the gravity vector is performed. Experimental and theoretical investigation of large (nonaxisymmetric) oscillations and breaking of liquid bridges are also conducted

Intermediate Tail Dependence: A Review and Some New Results

The concept of intermediate tail dependence is useful if one wants to quantify the degree of positive dependence in the tails when there is no strong evidence of presence of the usual tail dependence. We first review existing studies on intermediate tail dependence, and then we report new results to supplement the review. Intermediate tail dependence for elliptical, extreme value and Archimedean copulas are reviewed and further studied, respectively. For Archimedean copulas, we not only consider the frailty model but also the recently studied scale mixture model; for the latter, conditions leading to upper intermediate tail dependence are presented, and it provides a useful way to simulate copulas with desirable intermediate tail dependence structures.Comment: 25 pages, 1 figur

Investigating RFC1 expansions in sporadic amyotrophic lateral sclerosis

A homozygous AAGGG repeat expansion within the RFC1 gene was recently described as a common cause of CANVAS syndrome. We examined 1069 sporadic ALS patients for the presence of this repeat expansion. We did not discover any carriers of the homozygous AAGGG expansion in our ALS cohort, indicating that this form of RFC1 repeat expansions is not a common cause of sporadic ALS. However, our study did identify a novel repeat conformation and further expanded on the highly polymorphic nature of the RFC1 locus

Estimation of conditional laws given an extreme component

Let $(X,Y)$ be a bivariate random vector. The estimation of a probability of the form $P(Y\leq y \mid X >t)$ is challenging when $t$ is large, and a fruitful approach consists in studying, if it exists, the limiting conditional distribution of the random vector $(X,Y)$, suitably normalized, given that $X$ is large. There already exists a wide literature on bivariate models for which this limiting distribution exists. In this paper, a statistical analysis of this problem is done. Estimators of the limiting distribution (which is assumed to exist) and the normalizing functions are provided, as well as an estimator of the conditional quantile function when the conditioning event is extreme. Consistency of the estimators is proved and a functional central limit theorem for the estimator of the limiting distribution is obtained. The small sample behavior of the estimator of the conditional quantile function is illustrated through simulations.Comment: 32 pages, 5 figur

Genotypes and phenotypes for apolipoprotein E and Alzheimer disease in the Honolulu-Asia aging study

BACKGROUND: The utility of apolipoprotein E (ApoE) type as an indicator of genetic susceptibility to Alzheimer disease (AD) depends on the reliability of typing. Although ApoE protein isoform phenotyping is generally assumed equivalent to genotyping from DNA, phenotype-genotype differences have been reported. METHODS: ApoE genotype and phenotype results were examined for 3564 older (ages 71-93 years) Japanese-American male participants of the Honolulu-Asia Aging Study, an ongoing population-based study of aging and dementia. RESULTS: Both methods demonstrated similar associations of ApoE type with AD: a direct association with ApoE4 and a less dramatic inverse association ApoE2. Advanced age did not appear to influence the ApoE4-AD association. The association with AD among ApoE4 homozygotes [odds ratio (OR) = 14.7] was higher than expected based on an observed OR of 2.0 in heterozygotes. Phenotype-genotype nonconcordance was more frequent for ApoE2 than for ApoE4. The ApoE2 phenotype occurred at a frequency of 7.9% vs a genotype frequency of 4.9%, corresponding to a probability of 56% that an individual with ApoE2 phenotype had the same genotype. CONCLUSIONS: Whereas E4 and E2 phenotypes and genotypes were comparably associated with AD, neither method would be expected to substantially improve the efficiency of case finding in the context of population screening beyond prediction based on age and education. Nonconcordance of phenotype and genotype was substantial for E2 and modest for E4 in this population. The ApoE4-AD association was independent of age

Identification of anthranilate and benzoate metabolic operons of Pseudomonas fluorescens and functional characterization of their promoter regions

BACKGROUND: In an effort to identify alternate recombinant gene expression systems in Pseudomonas fluorescens, we identified genes encoding two native metabolic pathways that were inducible with inexpensive compounds: the anthranilate operon (antABC) and the benzoate operon (benABCD). RESULTS: The antABC and benABCD operons were identified by homology to the Acinetobacter sp. anthranilate operon and Pseudomonas putida benzoate operon, and were confirmed to be regulated by anthranilate or benzoate, respectively. Fusions of the putative promoter regions to the E. coli lacZ gene were constructed to confirm inducible gene expression. Each operon was found to be controlled by an AraC family transcriptional activator, located immediately upstream of the first structural gene in each respective operon (antR or benR). CONCLUSION: We have found the anthranilate and benzoate promoters to be useful for tightly controlling recombinant gene expression at both small (< 1 L) and large (20 L) fermentation scales

Representing addition and subtraction : learning the formal conventions

The study was designed to test the effects of a structured intervention in teaching children to represent addition and subtraction. In a post-test only control group design, 90 five-year-olds experienced the intervention entitled Bi-directional Translation whilst 90 control subjects experienced typical teaching. Post-intervention testing showed some significant differences between the two groups both in terms of being able to effect the addition and subtraction operations and in being able to determine which operation was appropriate. The results suggest that, contrary to historical practices, children's exploration of real world situations should precede practice in arithmetical symbol manipulation