Progressive Tetraparesis in a 57-Year-Old Man With Congenital Absence of an Anterior Spinal Artery: A Case of Anterior Spinal Cord Infarction

A 57-year-old man presented with sudden neck pain radiating down his arms. This pain progressed to bilateral upper and subsequently lower extremity weakness and numbness. His vitals were notable for systolic blood pressures lower than his baseline (down to 90 mm Hg). The patient’s neurological examination as well as magnetic resonance imaging of the cervical and thoracic spine localized to a lesion in the anterior spinal cord. The differential diagnosis for such an acute presentation included stroke, demyelination, intramedullary neoplasm, infection, metabolic myelopathy, and a dural arteriovenous fistula. Further imaging with angiography demonstrated that our patient lacked an anterior spinal artery. In its place, collateral flow from cervical artery branches provided sustenance to the anterior spinal cord. In the setting of hemodynamic instability, this variant anatomy likely predisposed the patient to ischemia, leading to the classic presentation of anterior cord syndrome. </jats:p

Intracranial infectious aneurysms: a comprehensive review

Intracranial infectious aneurysms, or mycotic aneurysms, are rare infectious cerebrovascular lesions which arise through microbial infection of the cerebral arterial wall. Due to the rarity of these lesions, the variability in their clinical presentations, and the lack of population-based epidemiological data, there is no widely accepted management methodology. We undertook a comprehensive literature search using the OVID gateway of the MEDLINE database (1950-2009) using the following keywords (singly and in combination): infectious, mycotic, cerebral aneurysm, and intracranial aneurysm. We identified 27 published clinical series describing a total of 287 patients in the English literature that presented demographic and clinical data regarding presentation, treatment, and outcome of patients with mycotic aneurysms. We then synthesized the available data into a combined cohort to more closely estimate the true demographic and clinical characteristics of this disease. We follow by presenting a comprehensive review of mycotic aneurysms, highlighting current treatment paradigms. The literature supports the administration of antibiotics in conjunction with surgical or endovascular intervention depending on the character and location of the aneurysm, as well as the clinical status of the patient. Mycotic aneurysms comprise an important subtype of potentially life-threatening cerebrovascular lesions, and further prospective studies are warranted to define outcome following both conservative and surgical or endovascular treatment

Abstract WMP59: Trends And Predictors Of Delay In Hospital Presentation After Symptom Onset Among Ischemic Stroke Patients: A Single-center Study

Background: Delivery of acute ischemic stroke therapies is contingent on the duration from last known normal (LKN) to emergency department arrival time (EDAT). Methods: We studied patients presenting to Yale-New Haven Hospital from 2010-2020 who met these criteria 1) ischemic stroke, 2) age ≥ 18, 3) not transferred from another hospital, and 4) stroke symptom onset prior to hospital presentation. The outcome was LKN to EDAT dichotomized at 4.5 hours. Temporal trends were assessed by linear regression. Covariates analyzed for association with later arrival were: age, gender, race, ethnicity, median household income &lt; 50,000 by ZIP, arrival means, and NIHSS. We built a multivariable logistic regression model by stepwise selection with variables significant at p-value < 0.05). Results: We included 5,242 ischemic stroke patients; 1,964 (37.5%) presented early (<4.5 hrs). Patients presenting early decreased from 47.2% to 32.3% over time (p<0.01, Figure 1 ) and downward slope was steeper among non-White patients. Compared to early presenters, late presenters were more likely younger (median 72 vs 74 years; p<0.001), of non-White race (35.3% vs 26.8%, p<0.001), of Hispanic ethnicity (8.2% vs 6.2%, p=0.010), have a median household income < 50,000 (27.0% vs 21.2%, p=&lt;0.001), arrive by means other than emergency medical services (EMS) (66.4% vs 85.8%, p&lt;0.001), and have an NIHSS &lt; 4 (57.5% vs 41.6%, p&lt;0.001). In a multivariable model, non-White race (OR 1.4, 95% C.I. 1.2-1.7), arrival by means other than EMS (OR 2.4, 95% C.I. 1.9-3.0), and NIHSS &lt; 4 (OR 1.6, 95% C.I. 1.3-1.9) were significant, independent predictors of presenting later. Conclusion: Frequency of ischemic stroke patients presenting beyond 4.5 hrs increased from 2010 to 2020. Non-White race, arriving by means other than EMS, and minor stroke symptoms were linked with delay in presentation. Further study is necessary to identify and target barriers to timely hospital presentation among ischemic stroke patients. </jats:p

Renal dysfunction as an independent predictor of outcome after aneurysmal subarachnoid hemorrhage: a single-center cohort study

BACKGROUND AND PURPOSE: Acute kidney injury occurs in 1% to 25% of critically ill patients with small increases in creatinine adversely affecting outcome. We sought to determine the burden of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage and whether this dysfunction affects outcome. METHODS: Between 1996 and 2008, 787 consecutive patients with aneurysmal subarachnoid hemorrhage were enrolled in our prospective database. Demographics, serum creatinine levels, and discharge modified Rankin scores were recorded, and changes in creatinine clearance were calculated. A multiple logistic regression was performed using known predictors for poor outcome after aneurysmal subarachnoid hemorrhage in addition to burden of contrast-enhanced imaging and change in creatinine clearance. RESULTS: One hundred seventy-nine (23.1%) patients were at risk for renal failure during their hospitalization. In a multivariate model, those patients who developed risk for renal failure were twice as likely to have a poor 3-month outcome (OR, 2.01; P=0.021). Survival curves comparing those not at risk, those at risk (increasing severity classes Risk, Injury, and Failure, and the 2 outcome classes Loss and End-Stage Kidney Disease [RIFLE] R), and those with renal injury or failure (RIFLE I and F) demonstrated that risk of death increases significantly as one progresses through the RIFLE classes (log rank, P\u3c0.0001). CONCLUSIONS: In a large, consecutive series of prospectively enrolled patients with aneurysmal subarachnoid hemorrhage, we demonstrate, using the newly defined RIFLE classification for risk of renal failure, that even seemingly insignificant decreases in creatinine clearance are associated with significantly worse 3-month outcomes. This study highlights the importance of close surveillance of renal function and stresses the value of renal hygiene in the aneurysmal subarachnoid hemorrhage population

Epidemiological trends in the neurological intensive care unit from 2000 to 2008

Intensive care units (ICU) specializing in the treatment of patients with neurological diseases (Neuro-ICU) have become increasingly common. However, there are few data on the longitudinal demographics of this patient population. Identifying admission trends may provide targets for improving resource utilization. We performed a retrospective analysis of admission logs for primary diagnosis, age, sex, and length of stay, for all patients admitted to the Neuro-ICU at Columbia University Medical Center (CUMC) between 2000 and 2008. From 2000 to 2008, inclusive, the total number of Neuro-ICU admissions increased by 49.9%. Overall mean patient age (54.6 ± 17.4 to 56.2 ± 18.0 years, p=0.041) and gender (55.9-50.3% female, p=0.005) changed significantly, while median length of stay (2 days) did not. When comparing the time period prior to construction of a larger Neuro-ICU (2000-2004) to that after completion (2005-2008), patient age (56.0 ± 17.6 compared to 56.9 ± 17.5 years, p=0.012) and median length of stay (1 compared to 2 days, p\u3c0.001) both significantly increased. Construction of a newer, larger Neuro-ICU at CUMC led to a substantial increase in admissions and changes in diagnoses from 2000 to 2008. Advances in neurocritical care, neurosurgical practices, and the local and global expansion and utilization of ICU resources likely led to differences in lengths of stay