Mars Prototype Rover Environmental Measurement System

In my senior project, the problem I am trying to solve is how to efficiently design, create, and install an original library onto a Mars prototype rover operating system and to further use that library to integrate a new weather measurement sensor device into the rover system with the necessary software and hardware implementations. This is an important and highly valued problem as many aerospace and other engineering companies utilize rovers and other autonomous systems for important research, explorations, and reconnaissance missions and goals. In solving this problem, I utilized many resources that were available to me such as advisors, clients, peer rover development teams, and many other academic videos and articles for understanding and guidance. I also spent a lot of time studying the existing code and hardware on the rover as I progressed on my senior project. In the end, I managed to successfully integrate my new sensor into the rover\u27s software and hardware design and was able to gather and display the desired measurements from the sensor through the rover\u27s operating system. The success of this project shows that although computer software and electrical hardware integration is complicated and tedious, advancements in this field of computer engineering could prove to be the key to propelling mankind into the next era of technology in engineering

Design and Synthesis of Novel and Selective Glycine Transporter‑1 (GlyT1) Inhibitors with Memory Enhancing Properties

We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo­[3,4-<i>c</i>]­pyrazoles amides (<b>21</b>–<b>50</b>) with good in vitro potency. Subsequent optimization of physicochemical and in vitro ADME properties produced several compounds with promising pharmacokinetic profiles. In vivo inhibition of GlyT1 was demonstrated for select compounds within this series by measuring the elevation of glycine in the cerebrospinal fluid (CSF) of rats after a single oral dose of 10 mg/kg. Ultimately, an optimized lead, compound <b>46</b>, demonstrated in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg