Distribution of the <i>COX-2 −1195</i> and <i>−765</i> genotypes and corresponding ORs in patients with IBD, CD or UC versus controls.

+<p>In the ulcerative colitis group, there are some missing data (n = 5) due to unsuccessful PCR for the <i>−765 G→C</i> polymorphism.</p><p>OR = Odds ratio; CI = confidence interval.</p

<i>COX-2</i> diplotype distribution and corresponding ORs in patients with IBD, CD or UC versus controls.

<p>OR = Odds ratio; CI = confidence interval.</p

Clinical characteristics of patients with Crohn's disease (n = 525).

+<p>Patients could be classified as having disease localisation in the upper gastrointestinal tract next to ileal, colonic or ileocolonic localisation.</p><p>*Note that data of patients are missing.</p

Diplotype-phenotype correlations in patients with Crohn's disease.

<p>Diplotype-phenotype correlations in patients with Crohn's disease in which the AG/AG diplotype served as reference.</p>+<p>Patients could be classified as having disease localisation in the upper gastrointestinal tract next to ileal, colonic or ileocolonic localisation.</p>*<p>For full notation see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015011#pone-0015011-t004" target="_blank">Table 4</a>.</p

Diplotype-phenotype correlations in patients with ulcerative colitis.

<p>Diplotype-phenotype correlations in patients with ulcerative colitis in which AG/AG served as reference.</p>#<p>For full notation see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015011#pone-0015011-t004" target="_blank">Table 4</a>.</p

Genotype distribution in patients with gastrointestinal cancer and controls.

<p>*Note that some patients or controls are missing because of failure of the genotyping.</p><p>**Adjusted for age.</p><p>GI, gastrointestinal; OR, odds ratio; CI, confidence interval.</p

Associations of the SNPs rs6214 and rs6898743 with gastrointestinal cancer.

<p>Only significant associations are visualized. Associations are given as follows: rs number of the SNP, genotype, odds ratio with corresponding 95% confidence interval. The homozygous most common genotype is taken as reference. EAC, esophageal adenocarcinoma; ESCC, esophageal squamous cell carcinoma.</p

Genotype distribution and ORs (95% CI) for the genotypes of SNPs rs6214 and rs6898743 in patients with EAC, ESCC, proximal CRC or distal CRC.

<p>EAC, esophageal adenocarcinoma; ESCC, esophageal squamous cell carcinoma; CRC, colorectal cancer.</p

Characteristics of the study population.

<p>n = number of patients or controls; GI, gastrointestinal; SD = standard deviation; EAC = esophageal adenocarcinoma; ESCC = esophageal squamous cell carcinoma;</p>1<p><i>p</i>-value mean age = 0.000;</p>2<p><i>p</i>-value mean age = 0.001.</p

Sequences of primers and probes, including the optimal annealing temperature and MgCl₂-concentration.

<p>F = forward; R = reverse; WT = wild type; VAR = variant; the bold underlined letters represent the wild type (most common) allele (Allele 1) and the variant allele (Allele 2) in the WT probe and VAR probe, respectively.</p