A CO observation of the galactic methanol masers

Context: We investigated the molecular gas associated with 6.7 GHz methanol masers throughout the Galaxy using a J=1-0 transition of the CO isotopologues. Methods:Using the 13.7-meter telescope at the Purple Mountain Observatory (PMO), we have obtained ^{12}CO and ^{13}CO (1-0) lines for 160 methanol masers sources from the first to the third Galactic quadrants. We made efforts to resolve the distance ambiguity by careful comparison with the radio continuum and HI 21 cm observations. Results: First, the maser sources show increased ^{13}CO line widths toward the Galactic center, suggesting that the molecular gas are more turbulent toward the Galactic center. This trend can be noticeably traced by the ^{13}CO line width. Second, the ^{12}CO excitation temperature shows a noticeable correlation with the H_2 column density. A possible explanation consistent with the collapse model is that the higher surface-density gas is more efficient to the stellar heating and/or has a higher formation rate of high-mass stars. Third, comparing the IRDCs, the maser sources on average have significantly lower H_2 column densities, moderately higher temperatures, and similar line widths. Fourth, in the mapped regions, 51 ^{13}CO cores have been revealed. Only 17 coincide with the radio continuum emission (F_{cm}>6 mJy), while a larger fraction (30 cores) coincide with the infrared emissions. The IR-bright and radio-bright sources exhibit significantly higher $^{12}$CO excitation temperatures than the IR-faint and radio-faint sources, respectively. Conclusions: The 6.7 GHz masers show a moderately low ionization rate but have a common-existing stellar heating that generates the IR emissions. The relevant properties can be characterized by the ^{12}CO and ^{13}CO (1-0) emissions in several aspects as described above.Comment: 38 pages, 13 figures, 4 tables, accepted to Astronomy and Astrophysic

Infall and outflow detections in a massive core JCMT 18354-0649S

We present a high-resolution study of a massive dense core JCMT 18354-0649S with the Submillimeter Array. The core is mapped with continuum emission at 1.3 mm, and molecular lines including CH$_{3}$OH ($5_{23}$-$4_{13}$) and HCN (3-2). The dust core detected in the compact configuration has a mass of $47 M_{\odot}$ and a diameter of 2\arcsec (0.06 pc), which is further resolved into three condensations with a total mass of $42 M_{\odot}$ under higher spatial resolution. The HCN (3-2) line exhibits asymmetric profile consistent with infall signature. The infall rate is estimated to be $2.0\times10^{-3} M_{\odot}\cdot$yr$^{-1}$. The high velocity HCN (3-2) line wings present an outflow with three lobes. Their total mass is $12 M_{\odot}$ and total momentum is $121 M_{\odot}\cdot$km s$^{-1}$, respectively. Analysis shows that the N-bearing molecules especially HCN can trace both inflow and outflow.Comment: 21 pages, 7 figure

Outflow activities in the young high-mass stellar object G23.44-0.18

We present an observational study towards the young high-mass star forming region G23.44-0.18 using the Submillimeter Array. Two massive, radio-quiet dusty cores MM1 and MM2 are observed in 1.3 mm continuum emission and dense molecular gas tracers including thermal CH$_3$OH, CH$_3$CN, HNCO, SO, and OCS lines. The $^{12}$CO (2--1) line reveals a strong bipolar outflow originated from MM2. The outflow consists of a low-velocity component with wide-angle quasi-parabolic shape and a more compact and collimated high-velocity component. The overall geometry resembles the outflow system observed in the low-mass protostar which has a jet-driven fast flow and entrained gas shell. The outflow has a dynamical age of $6\times10^3$ years and a mass ejection rate $\sim10^{-3} M_{\odot}$ year$^{-1}$. A prominent shock emission in the outflow is observed in SO and OCS, and also detected in CH$_3$OH and HNCO. We investigated the chemistry of MM1, MM2 and the shocked region. The dense core MM2 have molecular abundances of 3 to 4 times higher than those in MM1. The abundance excess, we suggest, can be a net effect of the stellar evolution and embedded shocks in MM2 that calls for further inspection.Comment: 8 figures, 3 tables, accepted to MNRA

MicroRNA-646 inhibits the proliferation of ovarian granulosa cells via insulin-like growth factor 1 (IGF-1) in polycystic ovarian syndrome (PCOS)

Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrinopathy in women. MicroRNAs (miRNAs) have been proven to play a crucial role in balancing the proliferation and apoptosis of granulosa cells (GCs) in PCOS. Material and methods: The miRNA of PCOS was screened by bioinformatics analysis, and microRNA 646 (miR-646) was found to be involved in insulin-related pathways by enrichment analysis. The cell counting kit-8 (CCK-8), cell colony formation, and the 5-ethynyl-2’-deoxyuridine (EdU) assays were used to explore the effect of miR-646 on proliferation of GCs, flow cytometry was used to measure the cell cycle and apoptosis, and Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) were used to explore the biological mechanism of miR-646. The human ovarian granulosa cells KGN were selected by measuring the miR-646 and via insulin-like growth factor 1 (IGF-1) levels and used for cell transfection. Results: Overexpressed miR-646 inhibited KGN cell proliferation, and silenced miR-646 advanced it. Most cells were arrested in the S phase of cell cycle with overexpressed-miR-646, while after silencing miR-646, cells were arrested in the G2/M phase. And the miR-646 mimic raised apoptosis in KGN cells. Also, a dual-luciferase reporter proved the regulation effect of miR-646 on IGF-1, miR-646 mimic inhibited IGF-1, and miR-646 inhibitor advanced IGF-1. The cyclin D1, cyclin-dependent kinase 2 (CDK2), and B-cell CLL/lymphoma 2 (Bcl-2) levels were inhibited with overexpressed-miR-646, while silenced-miR-646 promoted their expression, and the bcl-2-like protein 4 (Bax) level was the opposite. This study found that silenced-IGF1 antagonized the promotive effect of the miR-646 inhibitor on cell proliferation. Conclusions: MiR-646 inhibitor treatment can promote the proliferation of GCs by regulating the cell cycle and inhibiting apoptosis, while silenced-IGF-1 antagonizes it

ALMA reveals sequential high-mass star formation in the G9.62+0.19 complex

Stellar feedback from high-mass stars (e.g., H{\sc ii} regions) can strongly influence the surrounding interstellar medium and regulate star formation. Our new ALMA observations reveal sequential high-mass star formation taking place within one sub-virial filamentary clump (the G9.62 clump) in the G9.62+0.19 complex. The 12 dense cores (MM 1-12) detected by ALMA are at very different evolutionary stages, from starless core phase to UC H{\sc ii} region phase. Three dense cores (MM6, MM7/G, MM8/F) are associated with outflows. The mass-velocity diagrams of outflows associated with MM7/G and MM8/F can be well fitted with broken power laws. The mass-velocity diagram of SiO outflow associated with MM8/F breaks much earlier than other outflow tracers (e.g., CO, SO, CS, HCN), suggesting that SiO traces newly shocked gas, while the other molecular lines (e.g., CO, SO, CS, HCN) mainly trace the ambient gas continuously entrained by outflow jets. Five cores (MM1, MM3, MM5, MM9, MM10) are massive starless core candidates whose masses are estimated to be larger than 25 M_{\sun}, assuming a dust temperature of $\leq$ 20 K. The shocks from the expanding H{\sc ii} regions ("B" \& "C") to the west may have great impact on the G9.62 clump through compressing it into a filament and inducing core collapse successively, leading to sequential star formation. Our findings suggest that stellar feedback from H{\sc ii} regions may enhance the star formation efficiency and suppress the low-mass star formation in adjacent pre-existing massive clumps.Comment: Accepted to Ap

Infall and outflow motions in the high-mass star forming complex G9.62+0.19

We present the results of a high resolution study with the Submillimeter Array towards the massive star forming complex G9.62+0.19. Three sub-mm cores are detected in this region. The masses are 13, 30 and 165 M_{\sun} for the northern, middle and southern dust cores, respectively. Infall motions are found with HCN (4-3) and CS (7-6) lines at the middle core (G9.62+0.19 E). The infall rate is $4.3\times10^{-3}~M_{\odot}\cdot$yr$^{-1}$. In the southern core, a bipolar-outflow with a total mass about 26 M_{\sun} and a mass-loss rate of $3.6\times10^{-5}~M_{\odot}\cdot$yr$^{-1}$ is revealed in SO ($8_{7}-7_{7}$) line wing emission. CS (7-6) and HCN (4-3) lines trace higher velocity gas than SO ($8_{7}-7_{7}$). G9.62+0.19 F is confirmed to be the driving source of the outflow. We also analyze the abundances of CS, SO and HCN along the redshifted outflow lobes. The mass-velocity diagrams of the outflow lobes can be well fitted by a single power law. The evolutionary sequence of the cm/mm cores in this region are also analyzed. The results support that UC~H{\sc ii} regions have a higher blue excess than their precursors.Comment: 50 pages, 16 figures, 4 table

Compressed Magnetic Field in the Magnetically Regulated Global Collapsing Clump of G9.62+0.19

How stellar feedback from high-mass stars (e.g., H II regions) influences the surrounding interstellar medium and regulates new star formation is still unclear. To address this question, we observed the G9.62+0.19 complex in 850 mu m continuum with the James Clerk Maxwell Telescope/POL-2 polarimeter. An ordered magnetic field has been discovered in its youngest clump, the G9.62 clump. The magnetic field strength is determined to be similar to 1 mG. Magnetic field plays a larger role than turbulence in supporting the clump. However, the G9.62 clump is still unstable against gravitational collapse even if thermal, turbulent, and magnetic field support are taken into account together. The magnetic field segments in the outskirts of the G9.62 clump seem to point toward the clump center, resembling a dragged-in morphology, indicating that the clump is likely undergoing magnetically regulated global collapse. However, the magnetic field in its central region is aligned with the shells of the photodissociation regions and is approximately parallel to the ionization (or shock) front, indicating that the magnetic field therein is likely compressed by the expanding H II regions that formed in the same complex.Peer reviewe

ATOMS : ALMA Three-millimeter Observations of Massive Star-forming regions - XI. From inflow to infall in hub-filament systems

We investigate the presence of hub-filament systems in a large sample of 146 active proto-clusters, using (HCO+)-C-13 J = 1-0 molecular line data obtained from the ATOMS survey. We find that filaments are ubiquitous in proto-clusters, and hub-filament systems are very common from dense core scales (similar to 0.1 pc) to clump/cloud scales (similar to 1-10 pc). The proportion of proto-clusters containing hub-filament systems decreases with increasing dust temperature (T-d) and luminosity-to-mass ratios (L/M) of clumps, indicating that stellar feedback from H ii regions gradually destroys the hub-filament systems as proto-clusters evolve. Clear velocity gradients are seen along the longest filaments with a mean velocity gradient of 8.71 km s(-1) pc(-1) and a median velocity gradient of 5.54 km s(-1) pc(-1). We find that velocity gradients are small for filament lengths larger than similar to 1 pc, probably hinting at the existence of inertial inflows, although we cannot determine whether the latter are driven by large-scale turbulence or large-scale gravitational contraction. In contrast, velocity gradients below similar to 1 pc dramatically increase as filament lengths decrease, indicating that the gravity of the hubs or cores starts to dominate gas infall at small scales. We suggest that self-similar hub-filament systems and filamentary accretion at all scales may play a key role in high-mass star formation.Peer reviewe

The molecular emissions and the infall motion in the high-mass young stellar object G8.68−0.37

We present a multi-wavelength observational study towards the high-mass young stellar object G8.68−0.37. A single massive gas-and-dust core is observed in the (sub)millimetre continuum and molecular line emissions. We fitted the spectral energy distribution (SED) from the dust continuum emission. The best-fitting SED suggests the presence of two components with temperature of T_d = 20 and 120 K, respectively. The core has a total mass of up to 1.5 × 10^3 M_⊙ and a bolometric luminosity of 2.3 × 10^4 L_⊙. Both the mass and luminosity are dominated by the cold component (T_d= 20 K). The molecular lines of C^(18)O, C^(34)S, DCN and thermally excited CH_(3)OH are detected in this core. Prominent infall signatures are observed in the ^(12)CO (1 − 0) and (2 − 1). We estimated an infall velocity of 0.45 km s^(−1) and a mass infall rate of 7 × 10^(−4) M_⊙ yr^(−1). From the molecular lines, we have found a high DCN-to-HCN abundance ratio of 0.07. The overabundant DCN may originate from a significant deuteration in the previous cold pre-protostellar phase. And the DCN should now be rapidly sublimated from the grain mantles to maintain the overabundance in the gas phase