147 research outputs found

    Brownian motion meets Riemann curvature

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    The general covariance of the diffusion equation is exploited in order to explore the curvature effects appearing on brownian motion over a d-dimensional curved manifold. We use the local frame defined by the so called Riemann normal coordinates to derive a general formula for the mean-square geodesic distance (MSD) at the short-time regime. This formula is written in terms of O(d)O(d) invariants that depend on the Riemann curvature tensor. We study the n-dimensional sphere case to validate these results. We also show that the diffusion for positive constant curvature is slower than the diffusion in a plane space, while the diffusion for negative constant curvature turns out to be faster. Finally the two-dimensional case is emphasized, as it is relevant for the single particle diffusion on biomembranes.Comment: 16 pages and 3 figure

    Hybrid simulations of lateral diffusion in fluctuating membranes

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    In this paper we introduce a novel method to simulate lateral diffusion of inclusions in a fluctuating membrane. The regarded systems are governed by two dynamic processes: the height fluctuations of the membrane and the diffusion of the inclusion along the membrane. While membrane fluctuations can be expressed in terms of a dynamic equation which follows from the Helfrich Hamiltonian, the dynamics of the diffusing particle is described by a Langevin or Smoluchowski equation. In the latter equations, the curvature of the surface needs to be accounted for, which makes particle diffusion a function of membrane fluctuations. In our scheme these coupled dynamic equations, the membrane equation and the Langevin equation for the particle, are numerically integrated to simulate diffusion in a membrane. The simulations are used to study the ratio of the diffusion coefficient projected on a flat plane and the intramembrane diffusion coefficient for the case of free diffusion. We compare our results with recent analytical results that employ a preaveraging approximation and analyze the validity of this approximation. A detailed simulation study of the relevant correlation functions reveals a surprisingly large range where the approximation is applicable.Comment: 12 pages, 9 figures, accepted for publication in Phys. Rev.

    Reducing preventable adverse events in obstetrics by improving interprofessional communication skills - Results of an intervention study.

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    BACKGROUND: Progress in medicine involves the structured analysis and communication of errors. Comparability between the individual disciplines is only possible to a limited extent and obstetrics plays a special role: the expectation of a self-determined and joyful event meets with possibly serious complications in highly complex care situations. This must be managed by an interdisciplinary team with an increasingly condensed workload. Adverse events cannot be completely controlled. However, taking controllable risk factors into account and with a focused communication a reduction of preventable adverse events is possible. In the present study, the effect of interprofessional team training on preventable adverse events in an obstetric department was investigated. METHODS: The training consisted of a 4-h interdisciplinary training session based on psychological theories. Preventable adverse events were defined in six categories according to potential patterns of causation. 2,865 case records of a refence year (2018) and 2,846 case records of the year after the intervention (2020) were retrospectively evaluated. To determine the communication training effect, the identified preventable adverse events of 2018 and 2020 were compared according to categories and analyzed for obstetrically relevant controllable and uncontrollable risk factors. Questionnaires were used to identify improvements in self-reported perceptions and behaviors. RESULTS: The results show that preventable adverse events in obstetrics were significantly reduced after the intervention compared to the reference year before the intervention (13.35% in the year 2018 vs. 8.83% in 2020, p < 0.005). Moreover, obstetrically controllable risk factors show a significant reduction in the year after the communication training. The questionnaires revealed an increase in perceived patient safety (t(28) = 4.09, p < .001), perceived communication behavior (t(30) = -2.95, p = .006), and self-efficacy to cope with difficult situations (t(28) = -2.64, p = .013). CONCLUSIONS: This study shows that the communication training was able to reduce preventable adverse events and thus increase patient safety. In the future, regular trainings should be implemented alongside medical emergency trainings in obstetrics to improve patient safety. Additionally, this leads to theΒ strengthening of human factors and ultimately also to the prevention of second victims. Further research should follow up implementing active control groups and a randomized-controlled trail study design. TRIAL REGISTRATION: The study was approved by the Ethics Committee of University Hospital  (protocol code 114/19-FSt/Sta, date of approval 29 May 2019), study registration: NCT03855735

    Curvature-coupling dependence of membrane protein diffusion coefficients

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    We consider the lateral diffusion of a protein interacting with the curvature of the membrane. The interaction energy is minimized if the particle is at a membrane position with a certain curvature that agrees with the spontaneous curvature of the particle. We employ stochastic simulations that take into account both the thermal fluctuations of the membrane and the diffusive behavior of the particle. In this study we neglect the influence of the particle on the membrane dynamics, thus the membrane dynamics agrees with that of a freely fluctuating membrane. Overall, we find that this curvature-coupling substantially enhances the diffusion coefficient. We compare the ratio of the projected or measured diffusion coefficient and the free intramembrane diffusion coefficient, which is a parameter of the simulations, with analytical results that rely on several approximations. We find that the simulations always lead to a somewhat smaller diffusion coefficient than our analytical approach. A detailed study of the correlations of the forces acting on the particle indicates that the diffusing inclusion tries to follow favorable positions on the membrane, such that forces along the trajectory are on average smaller than they would be for random particle positions.Comment: 16 pages, 8 figure

    Π­Π»Π΅ΠΊΡ‚Ρ€ΠΎΠΏΡ€ΠΈΠ²ΠΎΠ΄ ΠΊΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ Π·Π°Π΄Π²ΠΈΠΆΠΊΠΈ, Π½Π° основС ВРН-АД

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    Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Ρ‹ исслСдования динамичСских Ρ€Π΅ΠΆΠΈΠΌΠΎΠ² Ρ€Π°Π±ΠΎΡ‚Ρ‹ асинхронного элСктропривода ΠΊΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ Π·Π°Π΄Π²ΠΈΠΆΠΊΠΈ. Π’ процСссС Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡŒ ΠΌΠΎΠ΄Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄Π½Ρ‹Ρ… процСссов асинхронного двигатСля Π² ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ½ΠΎΠΉ срСдС MATLAB Simulink. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ Ρ€Π°Π±ΠΎΡ‚Ρ‹ Π±Ρ‹Π»Π° смодСлирована систСма "тиристорный рСгулятор напряТСния – асинхронный Π΄Π²ΠΈΠ³Π°Ρ‚Π΅Π»ΡŒ", Ρ€Π΅Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Ρ‹ Ρ€Π΅ΠΆΠΈΠΌΡ‹ пуска ΠΈ динамичСского тормоТСния ΠΈ ΠΏΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Ρ‹ Π³Ρ€Π°Ρ„ΠΈΠΊΠΈ ΠΏΠ΅Ρ€Π΅Ρ…ΠΎΠ΄Π½Ρ‹Ρ… процСссов. Π˜ΡΡΠ»Π΅Π΄ΡƒΠ΅ΠΌΠ°Ρ систСма ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅Ρ‚ΡΡ Π² качСствС элСктропривода ΠΊΠ»ΠΈΠ½ΠΎΠ²ΠΎΠΉ Π·Π°Π΄Π²ΠΈΠΆΠΊΠΈ, устанавливаСмой Π½Π° ΠΌΠ°Π³ΠΈΡΡ‚Ρ€Π°Π»ΡŒΠ½ΠΎΠΌ Π½Π΅Ρ„Ρ‚Π΅ΠΏΡ€ΠΎΠ²ΠΎΠ΄Π΅. ЭкономичСская ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Π·Π°ΠΊΠ»ΡŽΡ‡Π°Π΅Ρ‚ΡΡ Π² Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΌ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠΈ рСсурса ΠΌΠ΅Ρ…Π°Π½ΠΈΠ·ΠΌΠ° ΠΈ элСктричСской части элСктропривода.In the work, the dynamic modes of operation of an asynchronous electric drive of a wedge gate valve are investigated. In the process of work, modeling of transient processes of an induction motor in the MATLAB Simulink software environment was carried out. As a result of the work, the system "thyristor voltage regulator - asynchronous motor" was simulated, the startup and dynamic braking modes were realized and the transient graphs were analyzed. The system under investigation is used as an electric drive of a wedge gate valve installed on a main oil pipeline. Economic efficiency consists in a significant increase in the life of the mechanism and the electrical part of the electric drive

    Анализ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΈ Π²Ρ‹Π±ΠΎΡ€Π° способа эксплуатации Бугмутского нСфтяного мСстороТдСния (ЯНАО)

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    ЦСлью Π΄Π°Π½Π½ΠΎΠΉ выпускной ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ Ρ€Π°Π±ΠΎΡ‚Ρ‹ являСтся ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ состояния Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ мСстороТдСния, стСпСни Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΎΠ΅ΠΊΡ‚Π½Ρ‹Ρ… Ρ€Π΅ΡˆΠ΅Π½ΠΈΠΉ ΠΈ прСдлоТСния ΠΏΠΎ ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΡŽ процСсса Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ мСстороТдСнияThe purpose of this final qualifying work is to study the state of development, the degree of implementation of design solutions and proposals for improving the development of field

    Communication and patient safety in gynecology and obstetrics - study protocol of an intervention study.

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    BACKGROUND: Patient safety is a key target in public health, health services and medicine. Communication between all parties involved in gynecology and obstetrics (clinical staff/professionals, expectant mothers/patients and their partners, close relatives or friends providing social support) should be improved to ensure patient safety, including the avoidance of preventable adverse events (pAEs). Therefore, interventions including an app will be developed in this project through a participatory approach integrating two theoretical models. The interventions will be designed to support participants in their communication with each other and to overcome difficulties in everyday hospital life. The aim is to foster effective communication in order to reduce the frequency of pAEs. If communication is improved, clinical staff should show an increase in work satisfaction and patients should show an increase in patient satisfaction. METHODS: The study will take place in two maternity clinics in Germany. In line with previous studies of complex interventions, it is divided into three interdependent phases. Each phase provides its own methods and data. Phase 1: Needs assessment and a training for staff (n = 140) tested in a pre-experimental study with a pre/post-design. Phase 2: Assessment of communication training for patients and their social support providers (n = 423) in a randomized controlled study. Phase 3: Assessment of an app supporting the communication between staff, patients, and their social support providers (n = 423) in a case-control study. The primary outcome is improvement of communication competencies. A range of other implementation outcomes will also be assessed (i.e. pAEs, patient/treatment satisfaction, work satisfaction, safety culture, training-related outcomes). DISCUSSION: This is the first large intervention study on communication and patient safety in gynecology and obstetrics integrating two theoretical models that have not been applied to this setting. It is expected that the interventions, including the app, will improve communication practice which is linked to a lower probability of pAEs. The app will offer an effective and inexpensive way to promote effective communication independent of users' motivation. Insights gained from this study can inform other patient safety interventions and health policy developments. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03855735; date of registration: February 27, 2019

    Curvature correction to the mobility of fluid membrane inclusions

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    For the first time, using rigorous low-Reynolds-number hydrodynamic theory on curved surfaces via a Stokeslet-type approach, we provide a general and concise expression for the leading-order curvature correction to the canonical, planar, Saffman-DelbrΓΌck value of the diffusion constant for a small inclusion embedded in an arbitrarily (albeit weakly) curved fluid membrane. In order to demonstrate the efficacy and utility of this wholly general result, we apply our theory to the specific case of calculating the diffusion coefficient of a locally curvature inducing membrane inclusion. By including both the effects of inclusion and membrane elasticity, as well as their respective thermal shape fluctuations, excellent agreement is found with recently published experimental data on the surface tension dependent mobility of membrane bound inclusions
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