The importance of individualized pharmaceutical therapy in the treatment of diabetes mellitus

Individualized pharmaceutical care for patients with diabetes is necessary for several reasons. First, diabetes is a highly complex disease caused by the interplay among genetic, physiological, and environmental factors that vary from individual to individual. Second, the profile of patients with diabetes has evolved to include people of all ages and socioeconomic backgrounds, with varying medical histories and health behaviors. Third, diabetes often occurs concurrently with other medical conditions, especially in certain groups, such as the elderly. While the treatment goals for all patients with diabetes are the sameto stabilize and maintain healthy blood glucose levels to prevent serious complicationsthe treatment plan used to achieve those goals will vary among individuals. There are many clinically proven options available for the treatment of diabetes. While there are well-established guidelines regarding which intervention is the best option for patients with either type 1 or type 2 diabetes, individual patient characteristics and needs should drive the care process. Assuring patient access to the wide variety of medications is crucial to meeting these needs and achieving quality, cost-effective diabetes management

Measuring helical FCG voltage with an electric field antenna

A method of measuring the voltage produced by a helical explosive flux compression generator using a remote electric field antenna is described in detail. The diagnostic has been successfully implemented on several experiments. Measured data from the diagnostic compare favorably with voltages predicted using the code CAGEN, validating our predictive modeling tools. The measured data is important to understanding generator performance, and is measured with a low-risk, minimally intrusive approach

Near-Equilibrium Polymorphic Phase Transformations in Praseodymium Under Dynamic Compression

We report the first experimental observation of sequential, multiple polymorphic phase transformations occurring in Praseodymium dynamically compressed using a ramp wave. The experiments also display the signatures of reverse transformations occuring upon pressure release and reveal the presence of small hysteresys loops. The results are in very good agreement with equilibrium hydrodynamic calculations performed using a thermodynamically consistent, multi-phase equation of state for Praseodymium, suggesting a near-equilibrium transformation behavior

Dynamic Strength of Metals in Shock Deformation

It is shown that the Hugoniot and the critical shear stress required to deform a metal plastically in shock compression can be obtained directly from molecular dynamics simulations without recourse to surface velocity profiles, or to details of the dislocation evolution. Specific calculations are shown for aluminum shocked along the [100] direction, and containing an initial distribution of microscopic defects. The presence of such defects has a minor effect on the Hugoniot and on the dynamic strength at high pressures. Computed results agree with experimental data

Isentropic Compression with a Rectangular Configuration for Tungstene and Tantalum, Computations and Comparison with Experiments

Isentropic compression experiments and numerical simulations on metals are performed at Z accelerator facility from Sandia National Laboratory and at Lawrence Livermore National Laboratory in order to study the isentrope, associated Hugoniot and phase changes of these metals [1]. 3D configurations have been calculated here to benchmark the new beta version of the electromagnetism package coupled with the dynamics in Ls-Dyna and compared with the ICE Z shots 1511 and 1555. The electromagnetism module is being developed in the general-purpose explicit and implicit finite element program LS-DYNA{reg_sign} in order to perform coupled mechanical/thermal/electromagnetism simulations. The Maxwell equations are solved using a Finite Element Method (FEM) for the solid conductors coupled with a Boundary Element Method (BEM) for the surrounding air (or vacuum). More details can be read in the reference [2], [3]

A Compact Torus Fusion Reactor Utilizing a Continuously Generated Strings of CT's. The CT String Reactor, CTSR.

A fusion reactor is described in which a moving string of mutually repelling compact toruses (alternating helicity, unidirectional Btheta) is generated by repetitive injection using a magnetized coaxial gun driven by continuous gun current with alternating poloidal field. An injected CT relaxes to a minimum magnetic energy equilibrium, moves into a compression cone, and enters a conducting cylinder where the plasma is heated to fusion-producing temperature. The CT then passes into a blanketed region where fusion energy is produced and, on emergence from the fusion region, the CT undergoes controlled expansion in an exit cone where an alternating poloidal field opens the flux surfaces to directly recover the CT magnetic energy as current which is returned to the formation gun. The CT String Reactor (CTSTR) reactor satisfies all the necessary MHD stability requirements and is based on extrapolation of experimentally achieved formation, stability, and plasma confinement. It is supported by extensive 2D, MHD calculations. CTSTR employs minimal external fields supplied by normal conductors, and can produce high fusion power density with uniform wall loading. The geometric simplicity of CTSTR acts to minimize initial and maintenance costs, including periodic replacement of the reactor first wall

Soft systems methodology: a context within a 50-year retrospective of OR/MS

Soft systems methodology (SSM) has been used in the practice of operations research and management science OR/MS) since the early 1970s. In the 1990s, it emerged as a viable academic discipline. Unfortunately, its proponents consider SSM and traditional systems thinking to be mutually exclusive. Despite the differences claimed by SSM proponents between the two, they have been complementary. An extensive sampling of the OR/MS literature over its entire lifetime demonstrates the richness with which the non-SSM literature has been addressing the very same issues as does SSM

Synthesis, Characterization and Magnetic Susceptibility of the Heavy Fermion Transition Metal Oxide LiV_{2}O_{4}

The preparative method, characterization and magnetic susceptibility \chi measurements versus temperature T of the heavy fermion transition metal oxide LiV_{2}O_{4} are reported in detail. The intrinsic \chi(T) shows a nearly T-independent behavior below ~ 30 K with a shallow broad maximum at about 16 K, whereas Curie-Weiss-like behavior is observed above 50-100 K. Field-cooled and zero-field-cooled magnetization M measurements in applied magnetic fields H = 10 to 100 G from 1.8 to 50 K showed no evidence for spin-glass ordering. Crystalline electric field theory for an assumed cubic V point group symmetry is found insufficient to describe the observed temperature variation of the effective magnetic moment. The Kondo and Coqblin-Schrieffer models do not describe the magnitude and T dependence of \chi with realistic parameters. In the high T range, fits of \chi(T) by the predictions of high temperature series expansion calculations provide estimates of the V-V antiferromagnetic exchange coupling constant J/k_{B} ~ 20 K, g-factor g ~ 2 and the T-independent susceptibility. Other possible models to describe the \chi(T) are discussed. The paramagnetic impurities in the samples were characterized using isothermal M(H) measurements with 0 < H <= 5.5 Tesla at 2 to 6 K. These impurities are inferred to have spin S_{imp} ~ 3/2 to 4, g_{imp} ~ 2 and molar concentrations of 0.01 to 0.8 %, depending on the sample.Comment: 19 typeset RevTeX pages, 16 eps figures included, uses epsf; to be published in Phys. Rev.

Development of the vacuum power flow channel for the Mini-G

Abstract not provide