“Ser mãe é padecer no paraíso.!? : percepções de mulheres mães sobre a maternidade

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Ceilândia, 2018.Introdução: A construção da maternidade inicia-se muito antes da concepção, e cooperam para este processo, atitudes transgeracionais e culturais, acoplados ao que se deseja de uma menina e de uma mulher dentro da família e da sociedade. As mudanças que acompanham a maternidade podem trazer consigo riscos de crises e desequilíbrios para a vida da mulher, pois as mesmas refletem no papel social, na necessidade de novas adaptações e no reajustamento de sua identidade. Portanto, faz-se necessário conhecer e compreender as percepções de mulheres mães sobre o papel ocupacional materno, e sua relação com o repertório ocupacional e perdas de papéis ocupacionais associadas ao processo da maternidade. Método: Trata-se de estudo qualitativo realizado em um hospital universitário da região centro-oeste do Brasil. A amostra foi composta por 12 mulheres, mães de crianças com desenvolvimento típico, que aguardavam consultas de rotinas. Os dados foram obtidos por meio de entrevista estruturada, gravada com anuência das participantes. Resultados: As mulheres entrevistadas encontravam-se na faixa etária entre 22 e 57 anos; cinco são mães primíparas e sete são mães multíparas; a escolaridade variou entre ensino fundamental incompleto a especialização completa; seis mães exerciam atividades remuneradas e seis mães não exerciam tais atividades. A pré-análise identificou 4 categorias analíticas: “Ser mãe é um dom!”; “Ser mãe é uma responsabilidade da mulher!”; “Ser mãe é padecer no paraíso!”; e perdas ocupacionais. Considerações Finais: A maternidade por si só, leva a modificação nas ocupações desempenhadas e nos papéis ocupacionais que as mulheres mães se engajam, causando muitas vezes perdas ocupacionais significativas. A terapia ocupacional pode atuar desenvolvendo e estimulando as habilidades de gerenciamento de tempo, simplificação de atividades, conservação de energia, técnicas de enfrentamento, técnicas de relaxamento, entre outras intervenções, objetivando o desempenho ocupacional satisfatório e desejado, de acordo com a subjetividade, contexto e cotidiano da mulher mãe

Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments

We previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein. Here we examined how this interaction contributes to KT-MT attachments. Depletion of Bub3 or dynein induced misaligned chromosomes, consistent with their role in KT-MT attachments. Unexpectedly, co-silencing of both proteins partially suppressed the misalignment phenotype and restored chromosome congression. Consistent with these observations, KT-MT attachments in co-depleted cells were stable, able to drive chromosome congression, and produce inter-and intra-kinetochore stretch, indicating they are functional. We suggest that a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.CESPU [02-GCQF-CICS-2011N]; FCT - Fundacao para a Ciencia e a Tecnologia [CEQUIMED-PEst-OE/SAU/UI4040/2014]; FCT [SFRH/BD/90744/2012]info:eu-repo/semantics/publishedVersio

Sentinel Lymph Node Biopsy in Penile Cancer: A Comparative Study Using Modified Inguinal Dissection

Introduction In the case of clinically negative inguinal regions in penile cancer, the treatments proposed might vary from careful observation to radical dissection for all patients. We evaluated the effectiveness of the sentinel lymph node biopsy using lymphoscintigraphy in patients with penile cancer and at least one negative inguinal region Materials and Methods In 18 patients, biopsy of the sentinel lymph node from the 32 negative inguinal regions and modified radical lymphadenectomy in these regions regardless of the biopsy results was performed. Clinical staging, pathological results of the sentinel and the other lymph nodes removed during lymphadenectomy, tumor behavior, local and inguinal recurrence and specific disease mortality were accessed. Results: The mean age of the study sample was 57.7 years (44 - 81 years) and the sentinel lymph node presented 0% false negative 66% sensitivity, and 79.3% specificity when compared with the modified inguinal lymphadenectomy as the gold standard treatment Conclusion: Sentinel lymph node biopsy is a feasible method of assessing the presence of regional metastasis in patients with penile cancer and clinically negative inguinal regions However, the optimal lymphoscintigraphy technique is still in evolution and requires further optimization at high volume centers34672573

Vesicostomy as a Protector of Upper Urinary Tract in Long-Term Follow-Up

Introduction: The aim of this study was to analyze the results of vesicostomy in children as a protector of the upper urinary tract and assess the adjustments taken by the caregivers. Materials and Methods: Twenty-one children who had undergone vesicostomy with the Blocksom technique were evaluated. Their mean age was 3.7 years (range, < 1 to 10 years). The evaluation consisted of kidney function tests, cystography, and analysis of complications. Twenty parents or caregivers were interviewed about their attitudes towards vesicostomy and its outcomes. Results: The main causes of the vesical dysfunction were posterior urethral valve in 7 (33.3%) and myelomeningocele in 5 patients (23.8%). Ten children (58.8%) showed improvement and 7 (41,2%) showed cure. Hydronephrosis observed in 17 children was alleviated or cured following the procedure. Kidney function, tested by creatinine clearance calculation, remained stable or improved in 20 patients (95.2%). Episodes of urinary tract infection and 1 (71.4%), vesicoureteral reflux lowered in 8 of 21 (38.1%) and 10 of 14 patients respectively. Subjective evaluation of 20 cases showed that 18 children (90.0%) remained dry during the day and 14 caregivers/parents (70.0%) felt they had acquired the skills necessary to handle a patient with vesicostomy. The mean global rate of satisfaction of the results of the surgery ranging from 0 (worst result) to 10 (best result) was 8.7. Conclusion: Vesicostomy is a simple surgery that protects the upper urinary tract, decreases hydronephrosis, and improves kidney function. There was adequate adjustment to vesicostomy and a positive global evaluation as reported by the parents and caregivers.629610

Intravesical Protrusion of the Prostate as a Predictive Method of Bladder Outlet Obstruction

Objective. Pressure-flow study is the gold standard for diagnosis of bladder outlet obstruction (BOO) A prospective study was carried out to compare urodynamic evaluation and measurement of intravesical protrusion of the prostate for diagnosing BOO Materials and Methods Patients presenting with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia and suspected BOO were prospectively evaluated through conventional urodynamics and classified according to the bladder outlet obstruction index (BOO!). They also underwent abdominal ultrasound measurement of the intravesical prostatic protrusion (IPP) and prostatic volume. The I PP was classified into three stages grade I under 5 mm; grade 11, between 5 and 10 mm, and grade III over 10 mm Results Forty-two patients, mean age 64.8 +/- 8.5 years were enrolled Transabdominal ultrasound determined a mean prostatic volume of 45 +/- 3 2 mL. Achieved IPP's values were the following: grade I - 12 (28.5%), grade II - 5 - (12%) and grade III - 25 (59.5%). The results of prostate volume differed significantly between obstructed and non-obstructed men (p = 0.033) and for IPP among obstructed, inconclusive and non-obstructed men (p = 0 016). For IPP, the area under ROC curve was 0.758 (95% confidence interval - 0.601 to 0 876), and the cutoff point to indicate BOO was 5 mm with 95 % sensitivity (75 1 - 99 2) and 50% specificity (28.2 - 71 8). Conclusion IPP and prostatic volume measured through abdominal ultrasound are noninvasive and accessible methods that significantly correlate to urinary BOO, and are useful in the diagnosis of male urinary obstructive problems.34562763

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.

We utilized induced pluripotent stem cells (iPSCs) derived from Huntington's disease (HD) patients as a human model of HD and determined that the disease phenotypes only manifest in the differentiated neural stem cell (NSC) stage, not in iPSCs. To understand the molecular basis for the CAG repeat expansion-dependent disease phenotypes in NSCs, we performed transcriptomic analysis of HD iPSCs and HD NSCs compared to isogenic controls. Differential gene expression and pathway analysis pointed to transforming growth factor β (TGF-β) and netrin-1 as the top dysregulated pathways. Using data-driven gene coexpression network analysis, we identified seven distinct coexpression modules and focused on two that were correlated with changes in gene expression due to the CAG expansion. Our HD NSC model revealed the dysregulation of genes involved in neuronal development and the formation of the dorsal striatum. The striatal and neuronal networks disrupted could be modulated to correct HD phenotypes and provide therapeutic targets

Ações de extensão no contexto coleta seletiva na escola: uma forma de educação ambiental

O objetivo desta atividade de extensão foi inserir os princípios da educação ambiental na vida de alunos e comunidades escolares da cidade de Passos, objetivando a propagação do conhecimento e prática da coleta seletiva, bem como disseminação de hábitos sustentáveis com orientação correta de descarte dos resíduos sólidos urbanos (RSU). Foram realizadas palestras, gincanas educativas e lançada para a comunidade uma campanha de coleta de materiais recicláveis. Observou-se que a gincana despertou um maior engajamento e participação ativa dos estudantes na campanha de arrecadação dos recicláveis, em que foram coletados cerca de 1574 kg de materiais, além dos 3329 bilhetes para o sorteio de uma bicicleta e cesta com doces. Concluiu-se que as atividades lúdicas e palestras, influenciaram positivamente no comportamento dos estudantes

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants

Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. Methods: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings: We used data from 751 studies including 4,372,000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-7.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Interpretation: Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults affected, has increased faster in low-income and middle-income countries than in high-income countries.Bin Zhou, Yuan Lu, Kaveh Hajifathalian, James Bentham … Robert J. Adams … Anne Taylor … et al. (WNCD Risk Factor Collaboration