High incidence of Angina pectoris in patients treated with 5-fluorouracil - A planned surveillance study with 102 patients

Objective: Angina pectoris, arrhythmic sudden death and myocardial infarction, all these cardiac events have occasionally been reported during 5-fluorouracil (5-FU) chemotherapy. Underlying mechanisms leading to these events are unknown; damage to the myocytes or vasospasms have been discussed. Methods: 102 consecutive and unselected patients were monitored with 12-lead ECG, echocardiography and radionuclide ventriculography prior to the first cycle of 5-FU chemotherapy and 3 months from baseline. Results: 19% of the patients developed reversible symptoms of angina pectoris during treatment which lasted up to 12 h after cessation of the infusion. Most of the 19 patients showed corresponding ECG changes. 6 out of the 19 patients with severe angina pectoris had subsequent coronary angiography. In none of these patients the coronary angiography showed coronary artery disease, but it showed low ventricular function (ejection fraction <50%) in 2 patients. The ejection fraction did not increase overtime. Arrhythmias were screened for with Holter monitoring during 5-FU chemotherapy. The frequency of bradycardia and ventricular extrasystoles increased significantly (p < 0.05) during treatment compared to arrhythmias in Holter monitoring 3 months later. Furthermore the Qtc time in the ECG 3 months later was significantly prolonged (p < 0.05) compared to baseline values. Conclusions:The incidence of angina pectoris in patients during 5-FU treatment seems higher than previously suspected. As myocardial ischemia can be fatal, attentiveness to these symptoms and immediate treatment are crucial. Copyright (C) 2003 S. Karger AG, Basel

Allan Sandage and the distance scale

Allan Sandage returned to the distance scale and the calibration of the Hubble constant again and again during his active life, experimenting with different distance indicators. In 1952 his proof of the high luminosity of Cepheids confirmed Baade's revision of the distance scale (H0 ~ 250 km s−1 Mpc−1). During the next 25 years, he lowered the value to 75 and 55. Upon the arrival of the Hubble Space Telescope, he observed Cepheids to calibrate the mean luminosity of nearby Type Ia supernovae (SNe Ia) which, used as standard candles, led to the cosmic value of H0 = 62.3 ± 1.3 ± 5.0 km s−1 Mpc−1. Eventually he turned to the tip of the red giant branch (TRGB) as a very powerful distance indicator. A compilation of 176 TRGB distances yielded a mean, very local value of H0 = 62.9 ± 1.6 km s−1 Mpc−1 and shed light on the streaming velocities in the Local Supercluster. Moreover, TRGB distances are now available for six SNe Ia; if their mean luminosity is applied to distant SNe Ia, one obtains H0 = 64.6 ± 1.6 ± 2.0 km s−1 Mpc−1. The weighted mean of the two independent large-scale calibrations yields H0 = 64.1 km s−1 Mpc−1 within 3.6

Simulative verification of a novel semi-active broadband energy harvester

This paper presents a semi-active broadband vibrational-energy harvesting system. Based on a non-resonant rotational generator, electronic circuitry was used to overcome the physical start-up restrictions. Due to the functional design it remains an energy harvester suitable for battery-less devices. For the first time a vibrational energy harvester is presented that allows standardization and thus higher volume production. A system layout, simulation, and measurement data will be shown