Learning to assess in higher education: a collaborative exploration of the interplay of 'formal' and 'informal' learning in the academic workplace

During 2005 to 2010 74 Centres for Excellence in Teaching and Learning (CETLs) were funded by the Higher Education Funding Council for England (HEFCE). As the name suggests, the aim of the CETL initiative was to reward and develop expertise in teaching and learning linked to particular areas of excellence. The CETL where the authors of this paper worked focused on developing Assessment for Learning (AfL) practices (McDowell et al., 2008). The paper discusses the findings from three research projects undertaken at the CETL which can be grouped under the broad theme of the exploration of assessment practices and academic development.However, while we are all interested in the ways academics learn to assess, the disciplinary/research backgrounds and theoretical assumptions we bring to our respective projects are quite different. Hodkinson and Macleod (2010) discuss conceptualisations of learning by referring to metaphors which are commonly used ‘when learning is thought about’ (p.174): learning as acquisition, as participation, as construction, as formation and as becoming. They argue that each metaphor assumes particular approaches to understanding and researching learning, and this also applies to the projects drawn on for this paper. The projects which have generated the data considered in this paper are, on the one hand, underpinned and informed by different conceptualisations of learning, bodies of literature and methodologies. On the other hand, the institutional context within which the data were collected and the data collection methods, i.e. semi-structured interviews, are the same. This paper also explores the benefits and challenges of working collaboratively on HE research questions from different theoretical perspectives. We would like to argue that that using data generated by all three projects is a legitimate, albeit unusual, way of advancing our understanding of learning in the academic workplace since it allows us to focus on the interface between informal and formal learning rather than discussing one type of learning at the expense of the other

Social moderation and calibration versus codification: a way forward for academic standards in higher education?

A key responsibility of higher education providers is the accurate certification of the knowledge and skills attained by their students. However, despite an intense focus on developing relevant quality assurance regulations, academic standards in higher education have remained resistant to explication and consistent application. In this paper, we initially deconstruct and evaluate academic standards and dominant practitioner perspectives on their nature and use, including techno-rational, sociocultural and sociomaterial approaches. The limited prior research on the effectiveness of calibration and social moderation processes is reviewed, highlighting the significant challenges in sharing tacitly held understandings of assessment criteria (attributes of quality) and standards (levels of achievement). Further complications are considered that arise from the varying expertise and power relationships of assessors and the complexities inherent in the development and use of codified artefacts for capturing and sharing standards. We opine that because of the difficulties in clearly representing and agreeing standards, it is unsurprising that there is little evidence of marking consistency to be found in the literature even in contexts where carefully crafted artefacts, such as rubrics, are in use. We conclude that effectiveness would be enhanced through sharing understandings more widely and refocusing the use of assessment codifications towards how they may catalyse effective social moderation and calibration dialogues. Dialogues that foreground individuals’ positions of consensus and dissensus at significant points of interpretation in the assessment process are identified within the paper

Degree standards project: calibration synthesis report

This report considers the issue of comparability of assessment standards in higher education, and the need to establish comparable standards. It considers the potential of calibration through social moderation processes to address the problem, gives a brief history of calibration and the recent experience of attempts in a range of disciplines undertaken by the Advance HE led Graduate Standards Project

Generation and Characterisation of a Canine EGFP-HMGA2 Prostate Cancer In Vitro Model

The architectural transcription factor HMGA2 is abundantly expressed during embryonic development. In several malignant neoplasias including prostate cancer, high re-expression of HMGA2 is correlated with malignancy and poor prognosis. The let-7 miRNA family is described to regulate HMGA2 negatively. The balance of let-7 and HMGA2 is discussed to play a major role in tumour aetiology. To further analyse the role of HMGA2 in prostate cancer a stable and highly reproducible in vitro model system is precondition. Herein we established a canine CT1258-EGFP-HMGA2 prostate cancer cell line stably overexpressing HMGA2 linked to EGFP and in addition the reference cell line CT1258-EGFP expressing solely EGFP to exclude EGFP-induced effects. Both recombinant cell lines were characterised by fluorescence microscopy, flow cytometry and immunocytochemistry. The proliferative effect of ectopically overexpressed HMGA2 was determined via BrdU assays. Comparative karyotyping of the derived and the initial CT1258 cell lines was performed to analyse chromosome consistency. The impact of the ectopic HMGA2 expression on its regulator let-7a was analysed by quantitative real-time PCR. Fluorescence microscopy and immunocytochemistry detected successful expression of the EGFP-HMGA2 fusion protein exclusively accumulating in the nucleus. Gene expression analyses confirmed HMGA2 overexpression in CT1258-EGFP-HMGA2 in comparison to CT1258-EGFP and native cells. Significantly higher let-7a expression levels were found in CT1258-EGFP-HMGA2 and CT1258-EGFP. The BrdU assays detected an increased proliferation of CT1258-HMGA2-EGFP cells compared to CT1258-EGFP and native CT1258. The cytogenetic analyses of CT1258-EGFP and CT1258-EGFP-HMGA2 resulted in a comparable hyperdiploid karyotype as described for native CT1258 cells. To further investigate the impact of recombinant overexpressed HMGA2 on CT1258 cells, other selected targets described to underlie HMGA2 regulation were screened in addition. The new fluorescent CT1258-EGFP-HMGA2 cell line is a stable tool enabling in vitro and in vivo analyses of the HMGA2-mediated effects on cells and the development and pathogenesis of prostate cancer

Chromosomal assignment of canine THADA gene to CFA 10q25

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

The Goldbeter-Koshland switch in the first-order region and its response to dynamic disorder

In their classical work (Proc. Natl. Acad. Sci. USA, 1981, 78:6840-6844), Goldbeter and Koshland mathematically analyzed a reversible covalent modification system which is highly sensitive to the concentration of effectors. Its signal-response curve appears sigmoidal, constituting a biochemical switch. However, the switch behavior only emerges in the "zero-order region", i.e. when the signal molecule concentration is much lower than that of the substrate it modifies. In this work we showed that the switching behavior can also occur under comparable concentrations of signals and substrates, provided that the signal molecules catalyze the modification reaction in cooperation. We also studied the effect of dynamic disorders on the proposed biochemical switch, in which the enzymatic reaction rates, instead of constant, appear as stochastic functions of time. We showed that the system is robust to dynamic disorder at bulk concentration. But if the dynamic disorder is quasi-static, large fluctuations of the switch response behavior may be observed at low concentrations. Such fluctuation is relevant to many biological functions. It can be reduced by either increasing the conformation interconversion rate of the protein, or correlating the enzymatic reaction rates in the network.Comment: 23 pages, 4 figures, accepted by PLOS ON

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Effectiveness and safety of opicapone in Parkinson’s disease patients with motor fluctuations: the OPTIPARK open-label study

Background The efficacy and safety of opicapone, a once-daily catechol-O-methyltransferase inhibitor, have been established in two large randomized, placebo-controlled, multinational pivotal trials. Still, clinical evidence from routine practice is needed to complement the data from the pivotal trials. Methods OPTIPARK (NCT02847442) was a prospective, open-label, single-arm trial conducted in Germany and the UK under clinical practice conditions. Patients with Parkinson’s disease and motor fluctuations were treated with opicapone 50 mg for 3 (Germany) or 6 (UK) months in addition to their current levodopa and other antiparkinsonian treatments. The primary endpoint was the Clinician’s Global Impression of Change (CGI-C) after 3 months. Secondary assessments included Patient Global Impressions of Change (PGI-C), the Unified Parkinson’s Disease Rating Scale (UPDRS), Parkinson’s Disease Questionnaire (PDQ-8), and the Non-Motor Symptoms Scale (NMSS). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs). Results Of the 506 patients enrolled, 495 (97.8%) took at least one dose of opicapone. Of these, 393 (79.4%) patients completed 3 months of treatment. Overall, 71.3 and 76.9% of patients experienced any improvement on CGI-C and PGI-C after 3 months, respectively (full analysis set). At 6 months, for UK subgroup only (n = 95), 85.3% of patients were judged by investigators as improved since commencing treatment. UPDRS scores at 3 months showed statistically significant improvements in activities of daily living during OFF (mean ± SD change from baseline: − 3.0 ± 4.6, p < 0.0001) and motor scores during ON (− 4.6 ± 8.1, p < 0.0001). The mean ± SD improvements of − 3.4 ± 12.8 points for PDQ-8 and -6.8 ± 19.7 points for NMSS were statistically significant versus baseline (both p < 0.0001). Most of TEAEs (94.8% of events) were of mild or moderate intensity. TEAEs considered to be at least possibly related to opicapone were reported for 45.1% of patients, with dyskinesia (11.5%) and dry mouth (6.5%) being the most frequently reported. Serious TEAEs considered at least possibly related to opicapone were reported for 1.4% of patients. Conclusions Opicapone 50 mg was effective and generally well-tolerated in PD patients with motor fluctuations treated in clinical practice. Trial registration Registered in July 2016 at clinicaltrials.gov (NCT02847442)