Infant feeding and child health and survival in Derbyshire in the early twentieth century.

This paper uses detailed records relating to feeding and health for a large sample of infants born in Derbyshire in the early twentieth century to provide a more detailed and nuanced picture than has previously been possible of the extent and duration of breast-feeding, reasons for ceasing to feed and the dangers of feeding in the early twentieth century. Results indicate that breast-feeding was the norm among working class British women in the early twentieth century, but the social gradient was the inverse to that found in Britain today. However this disguises much individual variation and early weaning was more common among twins, illegitimate infants, first births, and women in poor health, which placed infants at greater risk of death from many causes of death, but particularly gastro-intestinal infections. There is evidence that health visitors were successful both in promoting breast-feeding and in supporting safe hand-feeding.The data entry and early work leading to this paper were funded by a Wellcome Trust PhD studentship (grant number 044948/Z/95/Z), a British Academy Small Grant (SG: 31626) and small grants from the Population Investigation Committee and the Simon Population Trust

Geoarchaeological Approaches to Pictish Settlement Sites: Assessing Heritage at Risk

Due to the poor preservation of Pictish period buildings and the occupation deposits within them, very little is known of daily life in early medieval Scotland. In lowland and coastal areas, Pictish buildings are generally truncated by deep ploughing, coastal erosion, or urban development, while those uncovered in upland areas seem to have no preserved floor deposits for reasons that remain poorly understood. Geoarchaeological techniques are particularly effective in clarifying site formation processes and understanding post-depositional transformations. They are also a powerful research tool for identifying floor deposits, distinguishing their composition, and linking this to daily activities. However, archaeologists are often reluctant to apply geoarchaeological methods if they suspect preservation is poor or stratigraphy is not visible in the field. This study therefore employs an innovative suite of geoarchaeological techniques to evaluate the preservation of Pictish period buildings and the potential that fragmentary buildings have to reconstruct daily life in early medieval Scotland. Alongside literature analysis and a desk-based comparison with national soil datasets, over 400 sediment samples from three key settlement sites were subjected to integrated soil micromorphology, x-ray fluorescence, magnetic susceptibility, loss-on-ignition, pH, electrical conductivity and microrefuse analysis. The combined data were successful in generating new information about the depositional and post-depositional history of the sites, preservation conditions of the occupation deposits, and activity areas within domestic dwellings. Most significantly, the integrated approach demonstrated that ephemeral and fragmented occupation surfaces retain surviving characteristics of the use of space, even if floors are not preserved well enough to be clearly defined in the field or in thin-section. A partnership with Historic Environment Scotland has channelled this work into research-led guidelines aimed at communicating geoarchaeological methods and principles to a wider audience

Looking for an explanation for the excessive male mortality in England and Wales since the end of the 19th century.

Several papers have primarily considered a female disadvantage in mortality as something to explain, considering a male disadvantage to be a "natural condition". Even if, due to biological reasons, shorter life expectancy among males has been demonstrated, other factors need to be involved to explain firstly the increasing, and then the decreasing, of the male relative disadvantage over the past century. The principal aim of this paper is to provide a clearer picture of the major age-class and cause-of-death contributions to male excess mortality in England and Wales from 1881 to 2011. Results indicate a clear shift in contributions to the male disadvantage from differences occurring during the first year of life to those occurring in ageing people, and from tuberculosis, respiratory diseases, external causes and perinatal and congenital conditions to neoplasms and circulatory diseases. In contrast, the narrowing of the gap since 1981 seems to be most closely related to the decrease in the male disadvantage in respiratory diseases and to the simultaneous increasing in the female disadvantage in old-age diseases. The most important novelty of this research relates to the method: instead of using ratios to investigate gender differences in health, we use decomposition methods.Economic and Social Research Council, Digitising Scotland project, ES/K00574X/

Cardio classics revisited: focus on the role of amlodipine

Amlodipine is a long-acting, dihydropyridine calcium antagonist now widely used for lowering of elevated blood pressure. In recent years it has been shown to be effective in reducing both blood pressure and risk of cardiovascular (CV) events when used in combination with other antihypertensive agents of different classes. Strong evidence of cardiovascular benefit has been attained for combination of amlodipine with diuretics or angiotensin converting enzyme (ACE) inhibitors in a number of high-risk CV groups, including those with established coronary artery disease, diabetes, and at risk of renal disease. Combination therapies of amlodipine with other agents eliciting renin-angiotensin-aldosterone system blockade (angiotensin II receptor blockers or renin inhibitors) have been shown to be effective blood pressure-lowering strategies, but await the results of ongoing trials for direct evidence of benefit for renal disease progression and CV morbidity and mortality

The structure of the accretion disk in NGC 4258 derived from observations of its water vapor masers

A wealth of new information about the structure of the maser disk in NGC 4258 has been obtained from a series of 18 VLBA observations spanning three years, as well as from 32 additional epochs of spectral monitoring data from 1994 to the present, acquired with the VLA, Effelsberg, and GBT. The warp of the disk has been defined precisely. The thickness of the maser disk has been measured to be 12 microarcseconds (FWHM), which is slightly smaller than previously quoted upper limits. Under the assumption that the masers trace the true vertical distribution of material in the disk, from the condition of hydrostatic equilibrium the sound speed is 1.5 km/s, corresponding to a thermal temperature of 600K. The accelerations of the high velocity maser components have been accurately measured for many features on both the blue and red side of the spectrum. The azimuthal offsets of these masers from the midline (the line through the disk in the plane of the sky) and derived projected offsets from the midline based on the warp model correspond well with the measured offsets. This result suggests that the masers are well described as discrete clumps of masing gas, which accurately trace the Keplerian motion of the disk. However, we have continued to search for evidence of apparent motions caused by ``phase effects.'' This work provides the foundation for refining the estimate of the distance to NGC 4258 through measurements of feature acceleration and proper motion. The refined estimate of this distance is expected to be announced in the near future.Comment: 8 pages, 5 figures, to appear in proceedings of IAU Symposium 242 "Astrophysical Masers and their Environments", held in Alice Springs, March 200

Adapting the Own Children Method to allow comparison of fertility between populations with different marriage regimes.

The Own Children Method (OCM) is an indirect procedure for deriving age-specific fertility rates and total fertility from children living with their mothers at a census or survey. The method was designed primarily for the calculation of overall fertility, although there are variants that allow the calculation of marital fertility. In this paper we argue that the standard variants for calculating marital fertility can produce misleading results and require strong assumptions, particularly when applied to social or spatial subgroups. We present two new variants of the method for calculating marital fertility: the first of these allows for the presence of non-marital fertility and the second also permits the more robust calculation of rates for social subgroups of the population. We illustrate and test these using full-count census data for England and Wales in 1911

Socio-cultural inhibitors to use of modern contraceptive techniques in rural Uganda: a qualitative study.

INTRODUCTION: Family planning is one of the cost-effective strategies in reducing maternal and child morbidity and mortality rates. Yet in Uganda, the contraceptive prevalence rate is only 30% among married women in conjunction with a persistently high fertility rate of 6.2 children per woman. These demographic indicators have contributed to a high population growth rate of over 3.2% annually. This study examines the role of socio-cultural inhibitions in the use of modern contraceptives in rural Uganda. METHODS: This was a qualitative study conducted in 2012 among men aged 15-64 and women aged 15-49 in the districts of Mpigi and Bugiri in rural Uganda. Eighteen selected focus group discussions (FGDs), each internally homogeneous, and eight in-depth interviews (IDIs) were conducted among men and women. Data were collected on sociocultural beliefs and practices, barriers to modern contraceptive use and perceptions of and attitudes to contraceptive use. All interviews were tape recoded, translated and transcribed verbatim. All the transcripts were coded, prearranged into categories and later analyzed using a latent content analysis approach, with support of ATLAS.ti qualitative software. Suitable quotations were used to provide in-depth explanations of the findings. RESULTS: Three themes central in hindering the uptake of modern contraceptives emerged: (i) persistence of socio-cultural beliefs and practices promoting births (such as polygamy, extending family lineage, replacement of the dead, gender-based violence, power relations and twin myths). (ii) Continued reliance on traditional family planning practices and (iii) misconceptions and fears about modern contraception. CONCLUSION: Sociocultural expectations and values attached to marriage, women and child bearing remain an impediment to using family planning methods. The study suggests a need to eradicate the cultural beliefs and practices that hinder people from using contraceptives, as well as a need to scale-up family planning services and sensitization at the grassroots