Measurements of the model parameter in the littlest Higgs model with T-parity

In the Littlest Higgs model with T-parity, we study production processes of new gauge bosons at the international linear collider (ILC). Through Monte Carlo simulations of the production processes, we show that the heavy gauge boson masses can be determined very accurately at the ILC for a representative parameter point of the model. From the simulation result, we also discuss the determination of other model parameters at the ILC.Comment: 4 pages, 2 figures. Talk given at LCWS08, Chicago, November 200

Precision Measurements of Little Higgs Parameters at the International Linear Collider

We investigate a possibility of precision measurements for parameters of the Littlest Higgs model with T-parity at the International Linear Collider (ILC). The model predicts new gauge bosons (AH, ZH, and WH), among which the heavy photon (AH) is a candidate for dark matter. The masses of these new gauge bosons strongly depend on the vacuum expectation value that breaks a global symmetry of the model. Through Monte Carlo simulations of the processes: e+ e- ->AH ZH and e+ e- -> WH+ WH-, we show how precisely the masses can be determined at the ILC for a representative parameter point of the model. We also discuss the determination of the Little Higgs parameters and its impact on the future measurement of the thermal abundance of the dark matter relics in our universe.Comment: 22 pages, 10 figures, 6 tabl

Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group.

The bioorganic synthesis of an end-capped anti-HIV peptide from a recombinant protein was investigated. Cyanogen bromide-mediated cleavage of two Met-Gln sites across the target anti-HIV sequence generated an HIV-1 fusion inhibitor (SC35EK) analog bearing an N-terminal pyroglutamate (pGlu) residue and a C-terminal homoserine lactone (Hsl) residue. The end-capped peptide, pGlu-SC35EK-Hsl, had similar bioactivity and biophysical properties to the parent peptide, and an improved resistance to peptidase-mediated degradation was observed compared with the non-end-capped peptide obtained using standard recombinant technology

Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature

Marginal zone lymphoma (MZL) arising from the anterior mediastinum is rare. In the majority of reported cases, the tumor was incidentally discovered, reflecting its indolent clinical features. We present a 38-year-old woman who had no medical history, and presented with a bulky anterior mediastinal tumor complicated by life-threatening compression of the vasculature and bronchi. Biopsy specimens of the neoplasm suggested transformed diffuse large B-cell lymphoma (DLBCL) from MZL. To our best knowledge, this is the first case report of anterior mediastinum MZL associated with an aggressive clinical course and life-threatening complications likely due to transformation to DLBCL

Identification of minimal sequence for HIV-1 fusion inhibitors.

Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment. Recently, the virus-cell membrane fusion process has been identified as a promising target for the development of novel drugs against these resistant variants. In this study, we identified a 29-residue peptide fusion inhibitor, SC29EK, which shows activity comparable to the previously reported inhibitor SC35EK. Some residues in SC29EK not required for interaction with virus gp41 heptad repeat 1 (HR1) were replaced with a non-proteinogenic amino acid, 2-aminoisobutyric acid (Aib), to stabilize the alpha-helix structure and to provide resistance to peptidases

Commonality and variation in mental representations of music revealed by a cross-cultural comparison of rhythm priors in 15 countries

Music is present in every known society but varies from place to place. What, if anything, is universal to music cognition? We measured a signature of mental representations of rhythm in 39 participant groups in 15 countries, spanning urban societies and Indigenous populations. Listeners reproduced random ‘seed’ rhythms; their reproductions were fed back as the stimulus (as in the game of ‘telephone’), such that their biases (the prior) could be estimated from the distribution of reproductions. Every tested group showed a sparse prior with peaks at integer-ratio rhythms. However, the importance of different integer ratios varied across groups, often reflecting local musical practices. Our results suggest a common feature of music cognition: discrete rhythm ‘categories’ at small-integer ratios. These discrete representations plausibly stabilize musical systems in the face of cultural transmission but interact with culture-specific traditions to yield the diversity that is evident when mental representations are probed across many cultures