Graphene nanoplatelets/CeO2 nanotiles nanocomposites as effective antibacterial material for multiple drug-resistant bacteria.

Antibacterial agents with low toxicity to normal cells, redox activity and free radical scavenging property are urgently needed to address the global health crisis. The phenomenal conducting nature of graphene is a best fit to enhance the antibacterial properties of metal oxides. In this work, CeO2 nanotiles and graphene nanoplatelets/CeO2 nanotiles nanocomposites (G/CeO2) have been synthesized by a solvothermal method. The prepared materials have been characterized using XRD, FE-SEM, EDX, and UV-visible spectroscopy techniques to investigate their crystallinity, morphology, composition, and optical bandgap energies. The CeO2 and G/CeO2 nanocomposites have also been tested for antibacterial applications. The neat CeO 2 nanotiles sample inhibits the bacterial growth of Pseudomonas aeruginosa and Staphylococcus aureus up to 14.21% and 39.53% respectively. The antibacterial activity was tremendously enhanced using 25% graphene-loaded sample (G/CeO2-II) i.e., approximately 83% loss of P. aeruginosa and 89% in case of S. aureus has been observed. This can be attributed to the unique nano-architecture, oxidative stress due to the excellent ability of reversible conversion between the two electronic states of CeO2 and the stress exerted by the planar graphene and CeO2 nanotiles. Therefore, the G/CeO2 nanocomposites can find potential application as nano-antibiotics for controlling pathogens

Early Infantile Gangliosidosis GM1, a Rare Clinical Entity

Gangliosidosis is a rare lysosomal storage disease. There have been about 200 cases reported, to date. The Overall prevalence at birth of GM1 Gangliosidosis is estimated to be 1 in 100,000 to 300,000. It is an inherited enzyme deficiency of beta-galactosidase, which results in the accumulation of glycosphingolipids within the lysosomes. It leads to neurological, skeletal and dermatological manifestations. Inferred GM1 Gangliosidosis is a lysosomal storage disorder, affected by mutations in GLB1, encoding beta-galactosidase. The range of severity is from type 1 infantile disease, lethal in early childhood, to type 3 adult on set, resulting in gradually progressive neurological symptoms in adulthood. The case report relates to a 13 months old patient with early infantile type of Gangliosidosis. &nbsp

Functional Potential and Chemical Profile Analysis of Propolis Oil Extracted from Propolis of Balochistan

Propolis oil (PO) was examined for chemical composition, phenolic and flavonoid content, and antioxidant and antimicrobial potential. Phenolic and flavonoid contents were 2.388 ± 1.116 mg GAE/g and 0.579 ± 0.140 mg QE/g. Oil showed 64.59 ± 14.59% inhibition of DPPH radical and significant antibacterial activities against target bacteria. Salmonella typhi was found to be highly sensitive (27.23 ± 4.35 mm) to PO, compared to Escherichia coli (23.40 ± 3.21), Staphylococcus aureus (21.43 ± 2.80), and Klebsiella pneumoniae (21.26 ± 3.25). The MIC and MBS values of PO were 0.35 and 0.7 mg/mL for S. typhi and E. coli, whereas they were 0.7 and 1.4 mg/mL for S. aureus. Moreover, the PO was found to be bacteriostatic for K. pneumoniae. Aspergillus flavus was found to be highly sensitive to PO, with an effective growth inhibition percentage of 73%, followed by Aspergillus niger (70%), whereas Aspergillus parasiticus was less sensitive with 25% growth inhibition. Functional groups in PO were determined with an FTIR spectrophotometer, and alcohol, alkane, aldehydes, alkenes, and ketones groups were found to be present, whereas GC-MS analysis revealed the presence of 27 different medicinal compounds, among which α-copanene (29.85%), benzyl benzoate (26.8%), 2,4-bis[1-(4-hydroxyphenyl)isopropyl]phenol, acetophenone (14.92%), undecylenic aldehyde (7.46%), p-linalool (5.9%), and ethyl 3-phenylpropionate (4.47%) were found in abundance

Research on rumors surrounding food safety based on information source differences (a review)

Food is a basic human right since it is necessary for survival. Unsafe food threatens billions of people throughout the world. Every year, hundreds of thousands of people grow sick and die. Microbial, chemical, personal, and environmental hygiene are all issues that the food chain faces from farm to fork/plate. Human tragedies and economic disasters have been reported in the past as a result of purposeful or inadvertent personal behavior and government inability to ensure food safety and quality. The issue of food safety has gotten a lot of press. As a result, a Food Safety Information Platform (FSIP) based on machine learning and open data with a Chatbot based on cloud computing (MLODCCC) architecture was developed, which includes a nice Facebook hyperlink and chatbot interface for locating trustworthy food safety knowledge. Rumors about the safety of food goods instill fear in people, leading to a broad boycott and, as a result, significant economic loss. This study looked into the function of rumors among friends. The findings suggested that people choose to use news media information in interaction with friends because it is seen to be more reliable than other resources