VLBA determination of the distance to nearby star-forming regions I. The distance to T Tauri with 0.4% accuracy

In this article, we present the results of a series of twelve 3.6-cm radio continuum observations of T Tau Sb, one of the companions of the famous young stellar object T Tauri. The data were collected roughly every two months between September 2003 and July 2005 with the Very Long Baseline Array (VLBA). Thanks to the remarkably accurate astrometry delivered by the VLBA, the absolute position of T Tau Sb could be measured with a precision typically better than about 100 micro-arcseconds at each of the twelve observed epochs. The trajectory of T Tau Sb on the plane of the sky could, therefore, be traced very precisely, and modeled as the superposition of the trigonometric parallax of the source and an accelerated proper motion. The best fit yields a distance to T Tau Sb of 147.6 +/- 0.6 pc. The observed positions of T Tau Sb are in good agreement with recent infrared measurements, but seem to favor a somewhat longer orbital period than that recently reported by Duchene et al. (2006) for the T Tau Sa/T Tau Sb system.Comment: 24 pages, 3 pages, AASTEX format, accepted for publication in Ap

Localized bank collapse or regional event?

This study presents a detailed synopsis of the sedimentological and structural features displayed within an underdescribed enigmatic facies observed in the basal Lower Jurassic Kayenta Formation of the Colorado Plateau. The facies comprises pebble to cobble-sized clasts of fine to medium-grained crossbedded sandstone with mud-draped and deformed foresets, as well as clasts of parallel-laminated but highly contorted siltstone and mudstone, supported in a silty to sandy matrix. The deposits are internally deformed and show both ductile and brittle structures in close spatial proximity, with a consistent and pervasive westdirected sense of shear. The facies occurs consistently within the same approximate stratigraphic interval, at or near the base of the Kayenta Formation. It is, however, observed only at four localities, distributed in a crudely linear arrangement parallel to the Utah-Idaho trough, despite extensive studies of outcrops of the same stratigraphic interval widely distributed across both Utah and Arizona. This study interprets the depositional processes as that of a partially subaerial debris flow with depositional events perhaps taking place during the waning period after ephemeral stream activity. The clast morphology and composition suggests a local source for the sediment entrained within the flow, and a limited transport distance. All of these observations are difficult to reconcile with the consistency of the stratigraphic interval in which the facies occur, or with the regional distribution of preserved examples. Consequently, this study discusses the potential for a common and time-equivalent triggering mechanism across all examples, which may have regional significance in the Jurassic evolution of the region

Aeolian–lacustrine margins: implications for carbon capture and storage within the Rotliegend Group, Southern North Sea

The Southern North Sea Basins of the United Kingdom were renowned for their hydrocarbon resources and exploited extensively from the 1960s to the 1990s. The Permian Leman Sandstone in particular formed an excellent reservoir due to its extensive clean aeolian sediments and was subsequently explored for decades, resulting in a wealth of subsurface data that are now widely accessible. The strata of the Leman Sandstone comprises mixed continental deposits from aeolian, fluvial and lacustrine environments which interfinger with the saline lake deposits of the Silverpit Formation. With the potential reassessment of depleted gas reservoirs in the North Sea for use as sequestration targets for captured carbon dioxide, there is significant renewed interest in the reservoir geology of the Leman Sandstone. A regional study of the sedimentology and petrophysical properties of the Leman Sandstone and Silverpit formations within quadrants 43, 44, 48 and 49 of the Southern North Sea has been conducted. Multiple interactions between the depositional environments are observed, resulting in a complex interplay between aeolian and lacustrine transgressive/regressive events, and migration and expansion/contraction of the fluvial system. In wireline petrophysical data, each depositional environment, along with their transitional environments, form relatively distinct clusters that can be used as a predictive tool for reservoir interpretation in the absence of core, despite extensive sediment recycling between environments

Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups

OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium. METHODS: We harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis. RESULTS: In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethno-racial groups, some interethnic differences were found in the effects of risk factors on cognition. CONCLUSIONS: This study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethno-racial differences that warrant attention in the development of prevention strategies.OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for poststroke cognitive impairment (PSCI) using a standardized approach and individual participant data (IPD) from international cohorts in the Stroke and Cognition Consortium (STROKOG) consortium. METHODS: We harmonized data from 13 studies based in 8 countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardized cognitive domain scores. Domain-specific impairment was based on percentile cutoffs from normative groups, and associations between domain scores and risk factors were examined with 1-stage IPD meta-analysis. RESULTS: In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30% to 35% were impaired in individual domains 2 to 6 months after the index event. Diabetes mellitus and a history of stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking, and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethnoracial groups, some interethnic differences were found in the effects of risk factors on cognition. CONCLUSIONS: This study confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes mellitus, and points to ethnoracial differences that warrant attention in the development of prevention strategies.Peer reviewe

Discovery of Markers of Exposure Specific to Bites of Lutzomyia longipalpis, the Vector of Leishmania infantum chagasi in Latin America

Leishmania parasites are transmitted by the bite of an infected vector sand fly that injects salivary molecules into the host skin during feeding. Certain salivary molecules can produce antibodies and can be used as an indicator of exposure to a vector sand fly and potentially the disease it transmits. Here we identified potential markers of specific exposure to the sand fly Lutzomyia longipalpis, the vector of visceral leishmaniasis in Latin America. Initially, we determined which of the salivary proteins produce antibodies in humans, dogs, and foxes from areas endemic for the disease. To identify potential specific markers of vector exposure, we produced nine different recombinant salivary proteins from Lu. longipalpis and tested for their recognition by individuals exposed to another human-biting sand fly, Lu. intermedia, that transmits cutaneous leishmaniasis and commonly occurs in the same endemic areas as Lu. longipalpis. Two of the nine salivary proteins were recognized only by humans exposed to Lu. longipalpis, suggesting they are immunogenic proteins and may be useful in epidemiological studies. The identification of specific salivary proteins as potential markers of exposure to vector sand flies will increase our understanding of vector–human interaction, bring new insights to vector control, and in some instances act as an indicator for risk of acquiring disease

Linking Oviposition Site Choice to Offspring Fitness in Aedes aegypti: Consequences for Targeted Larval Control of Dengue Vectors

Controlling the mosquito Aedes aegypti, the predominant dengue vector, requires understanding the ecological and behavioral factors that influence population abundance. Females of several mosquito species are able to identify high-quality egg-laying sites, resulting in enhanced offspring development and survival, and ultimately promoting population growth. Here, the authors investigated egg-laying decisions of Ae. aegypti. Paradoxically, they found that larval survival and development were poorest in the containers females most often selected for egg deposition. Thus, egg-laying decisions may contribute to crowding of larvae and play a role in regulating mosquito populations. The authors also tested whether removal of the containers producing the most adult mosquitoes, a World Health Organization-recommended dengue prevention strategy, changes the pattern of how females allocate their eggs. Elimination of the most productive containers led to a more even distribution of eggs in one trial, but not another. These results suggest that behavioral adjustments by egg-laying females may lessen the effectiveness of a common mosquito control tactic. The authors advocate incorporating control strategies that take advantage of the natural egg-laying preferences of this vector species, such as luring egg-laying females to traps or places where their eggs will accumulate, but not develop

Non-Standard Errors

In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: Non-standard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for better reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants