The Ursinus Weekly, May 22, 1975

Dr. Cope accepts history post at U. of Nebraska • Questionnaire summarized • UC faculty hears speaker from AAUP • U.C. Plans for Bicentennial • From the cluttered desk of the U.S.G.A. president • George Bause wins Scotland scholarship • Editorial: Last moments • Focus: Ms. Swanson • Wolsey Hall: British study • Alvarez attends seminar • Changes at library: Dr. Yost resigns post • Letters to the editor: Pets • Alumni elects • Intramural golf winners • Senior comments: Geoffery Higgins • Commencement • Earns degree • From the president • Cub and Key elects • Senior Spotlight: Dave McNamara • Reflections • Spring festival review • Study center success • New professors appointed • Ursinus bear squad • Volunteers needed at Pennhurst • Mulch queen contest • Concert review: Jesse Colin Young • Miller chosen • Dick Allen returns • Lacrosse wins 2 • Women\u27s tennis given team honors • Baseball: Season ends wrap-up • New results • Golf wins seven • Faculty-student net tournament • Intramural winnershttps://digitalcommons.ursinus.edu/weekly/1039/thumbnail.jp

The Ursinus Weekly, May 22, 1975

Dr. Cope accepts history post at U. of Nebraska • Questionnaire summarized • UC faculty hears speaker from AAUP • U.C. Plans for Bicentennial • From the cluttered desk of the U.S.G.A. president • George Bause wins Scotland scholarship • Editorial: Last moments • Focus: Ms. Swanson • Wolsey Hall: British study • Alvarez attends seminar • Changes at library: Dr. Yost resigns post • Letters to the editor: Pets • Alumni elects • Intramural golf winners • Senior comments: Geoffery Higgins • Commencement • Earns degree • From the president • Cub and Key elects • Senior Spotlight: Dave McNamara • Reflections • Spring festival review • Study center success • New professors appointed • Ursinus bear squad • Volunteers needed at Pennhurst • Mulch queen contest • Concert review: Jesse Colin Young • Miller chosen • Dick Allen returns • Lacrosse wins 2 • Women\u27s tennis given team honors • Baseball: Season ends wrap-up • New results • Golf wins seven • Faculty-student net tournament • Intramural winnershttps://digitalcommons.ursinus.edu/weekly/1039/thumbnail.jp

Molecular traces of alternative social organization in a termite genome

Although eusociality evolved independently within several orders of insects, research into the molecular underpinnings of the transition towards social complexity has been confined primarily to Hymenoptera (for example, ants and bees). Here we sequence the genome and stage-specific transcriptomes of the dampwood termite Zootermopsis nevadensis (Blattodea) and compare them with similar data for eusocial Hymenoptera, to better identify commonalities and differences in achieving this significant transition. We show an expansion of genes related to male fertility, with upregulated gene expression in male reproductive individuals reflecting the profound differences in mating biology relative to the Hymenoptera. For several chemoreceptor families, we show divergent numbers of genes, which may correspond to the more claustral lifestyle of these termites. We also show similarities in the number and expression of genes related to caste determination mechanisms. Finally, patterns of DNAmethylation and alternative splicing support

The Duration of Zidovudine Benefit in Persons With Asymptomatic HIV Infection: Prolonged Evaluation of Protocol 019 of the AIDS Clinical Trials Group

Objective.—To determine the durability of zidovudine-induced delay in clinical progression of asymptomatic human immunodeficiency virus (HIV) disease and to assess the relationship between this effect and the entry CD4+ cell count.Design and Interventions.—Extended follow-up data from subjects participating in protocol 019 of the AIDS [acquired immunodeficiency syndrome] Clinical Trials Group were examined. Subjects were offered a total daily dose of 500 mg of open-label zidovudine after the unblinding of the original randomized trial in 1989. Original treatment groups included placebo, 500 mg of zidovudine, or 1500 mg of zidovudine daily in divided doses. Three distinct analyses were conducted to assess the duration of zidovudine's effect on progression to AIDS or death: (1) analysis of all follow-up information from all subjects, (2) analysis of all subjects but with follow-up of original placebo-assigned subjects censored at the time open-label zidovudine was initiated, and (3) analysis of the effect of initiating zidovudine in subjects initially assigned to receive placebo.Setting.—University-based and university-affiliated AIDS research clinics participating in AIDS Clinical Trials Group protocol 019.Patients.—A total of 1565 asymptomatic HIV-infected subjects with entry CD4+ cell counts less than 0.50×109/L (500/μL).Main Outcome Measure.—Time to progression to AIDS or death.Results.—During follow-up of up to 4.5 years (mean, 2.6 years), 232 subjects progressed to AIDS or died. In each of the three analyses described herein, zidovudine was associated with a significant (P=.008,.004,.007) decrease in the risk of such progression. However, each of these analyses also indicated a decreasing placebo:zidovudine relative risk with duration of use (P=.002,.08,.04), suggesting a nonpermanent effect. The duration of benefit appeared to be related to entry CD4+ cell count, with greater benefit in those with higher counts at entry. No significant differences in survival were found between those originally randomized to zidovudine or placebo.Conclusions.—Zidovudine at 500 mg/d caused a significant delay in progression to AIDS or death, but its earlier use in asymptomatic disease was not associated with an additional prolongation of survival compared with delayed initiation. The delay in progression diminished over time especially in subjects with entry CD4+ cell counts less than 0.30×109/L (300/μL). Treatment strategies that alter drug regimens before the loss of zidovudine benefit should be explored.(JAMA. 1994;272:437-442