107 research outputs found
The effect of temperature and body size on filtration rates of Limnoperna fortunei (Bivalvia, Mytilidae) under laboratory conditions
Full text linkPredicting the effect of climate change on temperate shallow lakes with the ecosystem model PCLake
Full text linkNutrient Changes in Saginaw Bay, Lake Huron, After the Establishment of the Zebra Mussel ( Dreissena polymorpha )
Full text linkPolycystic kidney diseases: From molecular discoveries to targeted therapeutic strategies
Get PDFPolycystic kidney diseases (PKDs) represent a large group of progressive renal disorders characterized by the development of renal cysts leading to end-stage renal disease. Enormous strides have been made in understanding the pathogenesis of PKDs and the development of new therapies. Studies of autosomal dominant and recessive polycystic kidney diseases converge on molecular mechanisms of cystogenesis, including ciliary abnormalities and intracellular calcium dysregulation, ultimately leading to increased proliferation, apoptosis and dedifferentiation. Here we review the pathobiology of PKD, highlighting recent progress in elucidating common molecular pathways of cystogenesis. We discuss available models and challenges for therapeutic discovery as well as summarize the results from preclinical experimental treatments targeting key disease-specific pathways
Effects of pyrrolidine dithiocarbamate on proliferation and nuclear factor-κB activity in autosomal dominant polycystic kidney disease cells
Full text linkPricing and actuarial approaches within the Australian National Disability Insurance Scheme
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Estimating zebra mussel impact on pelagic food webs: the role of size-specific grazing rates
No full textAdapting to a marketised system: Network analysis of a personalisation scheme in early implementation.
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