4 research outputs found
Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols
International audienceBenzimidazoles may be formed in high yield through the phosphite-triggered reductive cyclization of o-nitroaniline derivatives. This reaction was used for the one-pot synthesis of benzimidazoles from o-nitrophenols and isocyanides. The mechanism is discussed in relation with nitroso intermediates. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Multicomponent synthesis of fused benzimidazolopiperazines
International audienceWe present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation. © 2011 American Chemical Society