14 research outputs found
DNA Binding and Photocleavage Studies of Cobalt(III) Ethylenediamine Pyridine Complexes: [Co(en)2(py)2]3+ and [Co(en)2(mepy)2]3+
Two novel cobalt(III) pyridine complexes (1)
[Co(en)2(py)2]3+ and (2)
[Co(en)2(mepy)2]3+ (en=ethylenediamine, py=pyridine, and mepy=methylpyridine) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated by absorption, emission spectroscopy, viscosity measurements, DNA melting, and DNA photocleavage. Results suggest that the two complexes bind to DNA via groove mode and complex 2 binds more strongly to CT DNA than complex 1. Moreover, these Co(III) complexes have been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365 nm, cytotoxicity results of complexes are also showing anticancer activity
Zn(II), Cd(II) and Hg(II) metal complexes of 2-aminonicotinaldehyde: Synthesis, crystal structure, biological evaluation and molecular docking study
In this report, the ligand, 2-aminonicotinaldehyde (ANA) and its metal complexes Zn(ANA)(2)Cl-2], Cd (ANA)(2)Cl-2] and Hg(ANA)(2)Cl-2] have been synthesized and characterized by analytical and various spectroscopic (IR, Electronic, H-1 and C-13 NMR) studies. The single crystal X-ray diffraction studies of ANA and Zn(ANA)(2)Cl-2] complex have been discussed. It was found that intra/intermolecular hydrogen bonding exists in both compounds and N-atom of pyridine ring of ANA coordinated to the metal ion in tetrahedral fashion. Metal chlorides, ANA and its complexes were subjected to biological screening, antioxidant, in vitro cytotoxicity and EGFR (Epidermal growth factor receptor) targeting molecular docking studies which indicated the synergistic effect of metal complexes on the biological activity than the free ligand and metal chlorides. (C) 2017 Elsevier B.V. All rights reserved