164 research outputs found
Identity-Based Blind Signature Scheme with Message Recovery
Blind signature allows a user to obtain a signature on a message without revealing anything about the message to the signer. Blind signatures play an important role in many real world applications such as e-voting, e-cash system where anonymity is of great concern. Due to the rapid growth in popularity of both wireless communications and mobile devices, the design of secure schemes with low-bandwidth capability is an important research issue. In this paper, we present a new blind signature scheme with message recovery in the ID-based setting using bilinear pairings over elliptic curves. The proposed scheme is unforgeable with the assumption that the Computational Diffie-Hellman problem is hard. We compare our scheme with the related schemes in terms of computational and communicational point of view
DEVELOPMENT OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE AND LEVOCETIRIZINE DIHYDROCHLORIDE
A simple, precise and accurate method has been developed for simultaneous estimation of Ambroxol hydrochloride and Levocetirizine dihydrochloride. The proposed RP-HPLC method utilises Enable C18 G column (250 x 4.6mm, 5m), mobile phase consisting of Phosphate buffer pH 3.0: Methanol in the ratio of 20:80 (v/v) and UV detection at 236nm using a photodiode array detector. ambroxol hydrochloride and levocetirizine dihydrochloride were exposed to acidic, alkali, oxidative, thermal and photolytic stress conditions and the stressed samples were analysed by the proposed method. Peak homogeneity data of ambroxol hydrochloride and levocetirizine dihydrochloride in the stressed samples demonstrated the specificity of the method for their estimation in presence of degradants. The described method was linear over a range of 15 45 g/mL for ambroxol hydrochloride and 1 3 g/mL for levocetirizine dihydrochloride respectively. The method validation data showed excellent results for accuracy, precision, linearity, specificity, limit of detection, limit of quantification and robustness. The present method can be successfully used for routine quality control and stability studies
Investigation of Impact Energy Absorption of AA6061 and Composites: Role of Post-Aging Cooling Methods
Al6061 and its composites are widely employed in applications requiring high strength and impact resistance. Heat treatment, particularly ageing, is a well-established method for enhancing the mechanical properties of these composites. However, the influence of post-ageing cooling methods on the impact energy absorption capacity of Al6061 and its composites remains inadequately understood. This investigation aims to examine the impact energy absorption of Al6061 and its composites after ageing at 460°C for 2 hours, employing different cooling methods, including furnace cooling, air cooling, and water cooling. The composites were produced using the stir casting technique with varying weight fractions of graphite and SiC particles based on Taguchi's design of experiments. Charpy impact tests were conducted using a specialised testing machine. The results reveal that the impact energy absorption capacity of the composites is influenced by the cooling method employed after the ageing treatment. Furnace cooling demonstrated the highest impact energy absorption capacity compared to the other cooling methods, exhibiting a 28% increase compared to the monolithic aluminium alloy. Furthermore, it was observed that the impact energy absorption capacity of the composites did not improve with an increase in the weight fraction of SiC particles, while the addition of graphite negatively impacted the absorption capacity
Seasonal Variability of the Observed Barrier Layer in the Arabian Sea
The formation mechanisms of the barrier layer ( BL) and its seasonal variability in the Arabian Sea ( AS) are studied using a comprehensive dataset of temperature and salinity profiles from Argo and other archives for the AS. Relatively thick BL of 20-60 m with large spatial extent is found in the central-southwestern AS ( CSWAS), the convergence zone of the monsoon wind, during the peak summer monsoon ( July-August) and in the southeastern AS ( SEAS) and northeastern AS ( NEAS) during the winter ( January-February). Although the BL in the SEAS has been reported before, the observed thick BL in the central-southwestern AS during the peak summer monsoon and in the northeastern AS during late winter are the new findings of this study. The seasonal variability of BL thickness ( BLT) is closely related to the processes that occur during summer and winter monsoons. During both seasons, the Ekman processes and the distribution of low-salinity waters in the surface layer show a dominant influence on the observed BLT distributions. In addition, Kelvin and Rossby waves also modulate the observed BL thickness in the AS. The relatively low salinity surface water overlying the Arabian Sea high-salinity water ( ASHSW) provides an ideal ground for strong haline stratification in the CSWAS ( during summer monsoon) and in NEAS ( during winter monsoon). During summer, northward advection of equatorial low-salinity water by the Somali Current and the offshore advection of low-salinity water from the upwelling region facilitate the salinity stratification that is necessary to develop the observed BL in the CSWAS. In the SEAS, during winter, the winter monsoon current ( WMC) carries less saline water over relatively high salinity ambient water to form the observed BL there. The winter West India Coastal Current ( WICC) transports the low-salinity water from the SEAS to the NEAS, where it lies over the subducted ASHSW leading to strong haline stratification. Ekman pumping together with the downwelling Kelvin wave in the NEAS deepen the thermocline to cause the observed thick BL in the NEAS
Investigation of Impact Energy Absorption of AA6061 and Composites: Role of Post-Aging Cooling Methods
Al6061 and its composites are widely employed in applications requiring high strength and impact resistance. Heat treatment, particularly ageing, is a well-established method for enhancing the mechanical properties of these composites. However, the influence of post-ageing cooling methods on the impact energy absorption capacity of Al6061 and its composites remains inadequately understood. This investigation aims to examine the impact energy absorption of Al6061 and its composites after ageing at 460°C for 2 hours, employing different cooling methods, including furnace cooling, air cooling, and water cooling. The composites were produced using the stir casting technique with varying weight fractions of graphite and SiC particles based on Taguchi's design of experiments. Charpy impact tests were conducted using a specialised testing machine. The results reveal that the impact energy absorption capacity of the composites is influenced by the cooling method employed after the ageing treatment. Furnace cooling demonstrated the highest impact energy absorption capacity compared to the other cooling methods, exhibiting a 28% increase compared to the monolithic aluminium alloy. Furthermore, it was observed that the impact energy absorption capacity of the composites did not improve with an increase in the weight fraction of SiC particles, while the addition of graphite negatively impacted the absorption capacity
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015
Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context.
Methods: We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI).
Findings: Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa.
Interpretation: Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden.
Funding: Bill & Melinda Gates Foundation
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