Ethnobotanical Survey on Respiratory Disorders in Eastern Ghats of Andhra Pradesh, India

An Ethnopharmacological survey of the Eastern Ghats region of Andhra Pradesh, comprising Chittoor, Cuddapah, East Godavari, Guntur, Khammam, Krishna, Kurnool, Srikakulam, Visakhapatnam, Vijayanagaram and the West Godavari districts, was conducted during 2000-2005. Eighty-four species of folk drug plants belonging to 72 genera and 41 families were found to be used as a remedy for respiratory disorders by the rural people and forest ethnic people (Chenchus, Erukulas, Lambadas, Koyas, Kondareddies, Nukadoras, Yanadis). The scientific, vernacular and family names of these medicinal plants, along with the parts used and the mode of their administration are enumerated

Noise characteristics of upper surface blown configurations: Analytical Studies

Noise and flow results of upper surface blown configurations were analyzed. The dominant noise source mechanisms were identified from experimental data. From far-field noise data for various geometric and operational parameters, an empirical noise prediction program was developed and evaluated by comparing predicted results with experimental data from other tests. USB aircraft compatibility studies were conducted using the described noise prediction and a cruise performance data base. A final design aircraft was selected and theory was developed for the noise from the trailing edge wake assuming it as a highly sheared layer

Cationic Carbonyl Complexes of Rh(I) with Imidazoles

621-62

Integrated Management of the Yellow Mite, Polyphagotarsonemus latus (Banks), on Sweet Pepper Grown under Polyhouse

Different IPM modules were evaluated for the management of yellow mite, Polyphagotarsonemus latus (Banks) on sweet pepper grown under protected cultivation at the Indian Institute of Horticultural Research, Bangalore. Results indicated that application of module 1(spray of abamectin followed by ethion and abamectin) or module 2 (spray of abamectin followed by profenophos and abamectin) was significantly more effective (3.91-6.58 mites/ leaf) than module 3 (spray of dicofol followed by pongamia oil and neem seed kernal extract (5.79 -6.95 mites/ leaf) in the first two trials (Sept. 2002- Mar. 2003 and June - Dec.2003). IPM modules like module 4 (spray of dicofol followed by release of Amblyseius tetranychivorus and spray of Verticillium lecanii and module 5 (spray of dicofol followed by release of A. tetranychivorus and spray of pongamia oil (9.25-15.53 mites/leaf) were marginally effective during the first two trials. However, in the third trial (Mar. - Sept., 2004) all the revised modules, viz., abamectin followed by dicofol (M1), dicofol-fenazaquin (M2), fenazaquin-pongamia oil (M3) and organic module oxymetrin-neem soap (M4) were effective (2.30-3.03 mites/leaf) against the yellow mite

The Stability of Strange Star Crusts and Strangelets

We construct strangelets, taking into account electrostatic effects, including Debye screening, and arbitrary surface tension sigma of the interface between vacuum and quark matter. We find that there is a critical surface tension sigma_crit below which large strangelets are unstable to fragmentation and below which quark star surfaces will fragment into a crystalline crust made of charged strangelets immersed in an electron gas. We derive a model-independent relationship between sigma_crit and two parameters that characterize any quark matter equation of state. For reasonable model equations of state, we find sigma_crit typically of order a few MeV/fm^2. If sigma <= sigma_crit, the size-distribution of strangelets in cosmic rays could feature a peak corresponding to the stable strangelets that we construct.Comment: 11 pages, LaTe

DEVELOPMENT OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM FOR NATEGLINIDE AN ANTI-DIABETIC DRUG

Objective: The purpose of the present study was to develop an oral push-pull osmotic drug delivery system for the drug Nateglinide which is a bio pharmaceutics classification system (BCS) class II drug. Methods: The tablets were prepared by the wet granulation method using ingredients microcrystalline cellulose (Adsorbent), potassium chloride (Osmotic agent), poly ethylene glycol (4000 and 6000) (Hydrophilic polymer, Plasticizer), starch (Disintegrant), and aerosil. The granules were compacted by double compression method and were coated with eudragit by dipping method. Different batches were prepared to study the effect of the various ingredients and their effect on the release of the drug from the system by varying the concentrations of the ingredients in each batch. Dissolution was assessed using USP dissolution apparatus 2 in phosphate buffer pH 6.8 for 12 h. Results: Certain key findings observed includes a decrease in micro crystalline cellulose content reduced the release of the drug due to the reduction of the hydrophilic content in the tablet which complements the uptake of water from the surroundings, and increase in the ethylene glycol leads to decrease in the release which resulted due to excess swelling and increase in the osmotic agent concentration lead to satisfactory release of the drug and followed zero-order release. Conclusion: To conclude, the push-pull osmotic tablet of Nateglinide was able to deliver the drug in a controlled pattern for a prolonged period of time. This type of formulation can be used in conditions like hyperglycemia where the patient compliance can improve by reducing the dosing frequency and the plasma drug levels can be maintained, the total drug load is also reduced so that the dose related side-effects are also reduced. Keywords: Controlled release, Push-pull osmotic pump, Nateglinid

A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population

The autosomal DAZL (Deleted-in-Azoospermic-Like) gene, mapped to the short arm of the human chromosome 3, is the precursor for the Y-chromosomal DAZ cluster, which encodes for putative RNA-binding proteins. Mutations in the DAZL have been reported to be associated with spermatogenic failure in Taiwanese population but not in Caucasians. As there was no study on Indian populations, we have analysed the entire coding sequences of exons 2 and 3 of DAZL in a total of 1010 men from Indian subcontinent, including 660 infertile men with 598 non-obstructive azoospermia, 62 severe oligozoospermia and 350 normozoospermic fertile control men, to investigate whether mutation(s) in the DAZL is associated with male infertility. Interestingly, none of our samples (1010) showed A386G (T54A) mutation, which was found to be associated with spermatogenic failure in Taiwanese population. In contrast, A260G (T12A) mutation was observed in both infertile and normozoospermic fertile control men, without any significant association with infertile groups (χ2=0.342; p=0.556). Similarly, we have found a novel A437G (I71V) mutation, which is also present in both infertile and normozoospermic fertile control men without any significant difference (χ2=0.476; p=0.490). Our study clearly demonstrates the complete absence of the A386G (T54A) mutation in Indian subcontinent and the other two mutations- A260G (T12A) and A437G (I71V)- observed are polymorpic. Therefore, we conclude that these mutations in the DAZL gene are not associated with male infertility in Indian subcontinent

First Order Kaon Condensation in Neutron Stars: Finite Size Effects in the Mixed Phase

We study the role of Coulomb and surface effects on the phase transition from dense nuclear matter to a mixed phase of nuclear and kaon-condensed matter. We calculate corrections to the bulk calculation of the equation of state (EOS) and the critical density for the transition by solving explicitly for spherical, cylindrical, and planar structures. The importance of Debye screening in the determination of the charged particle profiles is studied in some detail. We find that the surface and Coulomb contributions to the energy density are small, but that they play an important role in the determination of the critical pressure for the transition, as well as affecting the size and geometry of favored structures. This changes the EOS over a wide range of pressure and consequently increases the maximum mass by about 0.1 solar masses. Implications for transport properties of the mixed phase are also discussed.Comment: 18 pages, 6 figure