Satellite Remote Sensing and Field Studies on Narrowing of Three Sea Mouths of Pulicat Lake Sanctuary and Ecological Impact

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Nanomedicine Clinical Use, Regulatory and Toxicology Issues in Europe

Nano medicine is a revolutionizing field that can benefit both diagnosis and treatment and contribute to a better quality of life. Despite the expected huge benefits, the potential risks on human health are significant as well. This thesis aims to defense a perspective that in case of nascent technologies, where the data are still emerging and scientific uncertainty prevails, risk governance should sustain the process of scientific knowledge by developing guidelines, codes of conduct and public information and provide a minimum level of safety acceptable to protect human health. Although Nano medicine is at an early stage of development some cautious measures should be taken that will provide regulatory mechanisms able to respond to the challenges posed by Nano medicine, establish a minimum level of safety but will also allow the further promotion of scientific knowledge. This multidisciplinary approach can contribute in adopting regulatory choices and tools that will help manage the risks, protect human health and promote scientific knowledge.  As the technologies are designed based on a clear understanding of a particular disease, disease specific oriented focus is required for the development of novel pharmaceuticals. In addition, it will be important to establish a case-by-case approach to clinical and regulatory evaluation of each Nano pharmaceutical. High priority should be given to enhancing communication and exchange of information among academia, industry and regulatory agencies encompassing all facets of this multidisciplinary approach. Keywords: novel pharmaceuticals, Nano pharmaceuticals, toxicological issues, clinical use, Nano medicine

Tuberculoma of the liver

We report an isolated giant solid macronodular tuberculoma in an 8-year-old boy. A large-space-occupying lesion in the right lobe with nodular surface and hard consistency mimicked liver malignancy. This case is unusual as the ultrasonography, computed tomography scan, and aspiration cytology were all suggestive of a malignant tumor. Laparotomy confirmed a 15 x 10 cm nodular tumor present in the right lobe of liver. The segments 5, 6, 7, and 8 were excised. The histopathology revealed tuberculosis

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Not AvailableThe effect of dietary inclusion of solvent extracted pongamia cake (SPC) and iso propyl alcohol (IPA) treated SPC supplemented with protease (4000 U kg-1), phytase (400 U kg-1) and liver tonic (1 g kg-1) using 360 day old commercial broiler chicks. At 60 g kg-1 level, growth depression and poor FCR caused by the experimental diets could not be alleviated by enzymes/liver tonic supplementation. Dietary inclusion of SPC increased percent giblet weight. Pancreas, abdominal fat, HI titres to SRBC, CMI response to PHA-P and relative weight of spleen were similar in all the dietary groups. However, bursa weight was (p<0.05) higher in SPC supplementation with phytase (400 U kg-1) than control. The serum protein levels (p<0.05) increased in IPA treated SPC at 60 g kg-1 at 3rd week of age. The serum cholesterol level was significantly (p<0.05) higher in SPC incorporated diet with supplementation with liver tonic. The pongamia cake did not influence the activity of alkaline phosphatase. The histological changes suggested that pongamia cake leads to hepatotoxicity and nephrotoxicity in broilers. It can be concluded that, supplementation of enzymes/liver tonic cannot alleviate the toxic effects of SPC or IPA treated pongamia cake at 60 g kg-1 level in the diet. Effect of Enzymes and Liver Tonic Supplementation on Performance of Broiler Chicken Fed Processed Pongamia (Pongamia glabra vent) Cake | Request PDF. Available from: https://www.researchgate.net/publication/283201642_Effect_of_Enzymes_and_Liver_Tonic_Supplementation_on_Performance_of_Broiler_Chicken_Fed_Processed_Pongamia_Pongamia_glabra_vent_Cake [accessed Nov 06 2018].Not Availabl

EVALUATION OF ANTICANCER ACTIVITY OF PARKINSONIA ACULEATA LEAVES EXTRACT ON EHRLICH'S ASCITES CARCINOMA-INDUCED MICE.

 Objective: The objective of the study was to investigate the anticancer activity of the ethanolic extract of Parkinsonia aculeata (EEPA) leaves. Methods: Anticancer activity of P. aculeata (EEPA) of leaf extract was evaluated in Swiss albino mice against Ehrlich ascites carcinoma (EAC) cell line at the doses of 200 and 400 mg/kg body weight orally. The extracts were administered for 14 consecutive days. 24 h of the last dose and 18 h of fasting, the mice were sacrificed, and the anticancer effect of EEPA was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight, hematological parameters, and biochemical parameters of EAC bearing mice.Results: P. aculeata extracts showed a significant decrease in (p&lt;0.01) tumor volume, viable cell count, tumor weight, and elevated the life span of EAC bearing mice. Hematological profile such as red blood cell, hemoglobin count reverted to normal level in EEPA treated mice. The extracts significantly (p&lt;0.05) decreased the levels of lipid peroxidation and significantly (p&lt;0.05) increased the levels of reduced glutathione, superoxide dismutase and catalase.Conclusion: The results showed that the EEPA was effective in inhibiting the tumor growth in ascitic models and that is comparable to 5-fluorouracil.Â

Policy Paper 01/2018

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