Auditory cortical responses in patients with cochlera implants

Currently, the most commonly used electrophysiological tests for cochlear implant evaluation are Averaged Electrical Voltages (AEV), Electrical Advisory Brainstem Responses (EABR) and Neural Response Telemetry (NRT). The present paper focuses on the study of acoustic auditory cortical responses, or slow vertex responses, which are not widely used due to the difficulty in recording, especially in young children. Aims of this study were validation of slow vertex responses and their possible applications in monitoring postimplant results, particularly restoration of hearing and auditory maturation. In practice, the use of tone-bursts, also through hearing aids or cochlear implants, as in slow vertex responses, allows many more frequencies to be investigated and louder intensities to be reached than with other tests based on a click as stimulus. Study design focused on latencies of N1 and P2 slow vertex response peaks in cochlear implants. The study population comprised 45 implant recipients (aged 2 to 70 years), divided into 5 different homogeneous groups according to chronological age, age at onset of deafness, and age at implantation. For each subject, slow vertex responses and free-field auditory responses (PTAS) were recorded for tone-bursts at 500 and 2000 Hz before cochlear implant surgery (using hearing aid amplification) and during scheduled sessions at 3rd and 12th month after implant activation. Results showed that N1 and P2 latencies decreased in all groups starting from 3rd through 12th month after activation. Subjects implanted before school age or at least before age 8 yrs showed the widest latency changes. All subjects showed a reduction in the gap between subjective thresholds (obtained with free field auditory responses) and objective thresholds (obtained with slow vertex responses), obtained in presurgery stage and after cochlear implant. In conclusion, a natural evolution of neurophysiological cortical activities of the auditory pathway, over time, was found especially in young children with prelingual deafness and implanted in preschool age. Cochlear implantation appears to provide hearing restoration, demonstrated by the sharp reduction of the gap between subjective free field auditory responses and slow vertex responses threshold obtained with hearing aids vs. cochlear implant

Laser processing optimization for large-area perovskite solar modules

The industrial exploitation of perovskite solar cell technology is still hampered by the lack of repeatable and high-throughput fabrication processes for large-area modules. The joint efforts of the scientific community allowed to demonstrate high-performing small area solar cells; however, retaining such results over large area modules is not trivial. Indeed, the development of deposition methods over large substrates is required together with additional laser processes for the realization of the monolithically integrated cells and their interconnections. In this work, we develop an efficient perovskite solar module based on 2D material engineered structure by optimizing the laser ablation steps (namely P1, P2, P3) required for shaping the module layout in series connected sub-cells. We investigate the impact of the P2 and P3 laser processes, carried out by employing a UV pulsed laser (pulse width = 10 ns; lambda = 355 nm), over the final module performance. In particular, a P2 process for removing 2D material-based cell stack from interconnection area among adjacent cells is optimized. Moreover, the impact of the P3 process used to isolate adjacent sub-cells after gold realization over the module performance once laminated in panel configuration is elucidated. The developed fabrication process ensures high-performance repeatability over a large module number by demonstrating the use of laser processing in industrial production

Synergic use of two-dimensional materials to tailor interfaces in large area perovskite modules

In the field of halide perovskite solar cells (PSCs), interface engineering has been conceptualized and exploited as a powerful mean to improve solar cell performance, stability, and scalability. In this regard, here we propose the use of a multi two-dimensional (2D) materials as intra and inter layers in a mesoscopic PSCs. By combining graphene into both compact and mesoporous TiO2, Ti3C2Tx MXenes into the perovskite absorbing layer and functionalized-MoS2 at the interface between perovskite and the hole transporting layer, we boost the efficiency of PSCs (i.e., +10%) compared to the 2D materials-free PSCs. The optimized 2D materials-based structure has been successfully extended from lab-scale cell dimensions to large area module on 121 cm2 substrates (11 x11 cm2) till to 210 cm2 substrates (14.5 x14.5 cm2) with active area efficiency of 17.2% and 14.7%, respectively. The remarkable results are supported by a systematic statistical analysis, testifying the effectiveness of 2D materials interface engineering also on large area devices, extending the 2D materials-perovskite photovoltaic technology to the industrial exploitation

Lignin: a sustainable antiviral coating material

Transmission of viruses through contact with contaminated surfaces is an important pathway for the spread of infections. Antiviral surface coatings are useful to minimize such risks. Current state-of-the-art approaches toward antiviral surface coatings either involve metal-based materials or complex synthetic polymers. These approaches, however, even if successful, will have to face great challenges when it comes to large-scale applications and their environmental sustainability. Here, an antiviral surface coating was prepared by spin-coating lignin, a natural biomass residue of the paper production industry. We show effective inactivation of herpes simplex virus type 2 (>99% after 30 min) on a surface coating that is low-cost and environmentally sustainable. The antiviral mechanism of the lignin surface was investigated and is attributed to reactive oxygen species generated upon oxidation of lignin phenols. This mechanism does not consume the surface coating (as opposed to the release of a specific antiviral agent) and does not require regeneration. The coating is stable in ambient conditions, as demonstrated in a 6 month aging study that did not reveal any decrease in antiviral activity. This research suggests that natural compounds may be used for the development of affordable and sustainable antiviral coatings

Combining Mini-Mental State Examination and Montreal Cognitive Assessment for assessing the clinical efficacy of cholinesterase inhibitors in mild Alzheimer's disease: a pilot study

Current drugs for Alzheimer's Disease (AD), such as cholinesterase inhibitors (ChEIs), exert only symptomatic activity. Different psychometric tools are needed to assess cognitive and non-cognitive dimensions during pharmacological treatment. In this pilot study, we monitored 33 mild-AD patients treated with ChEIs. Specifically, we evaluated the effects of 6 months (Group 1 = 17 patients) and 9 months (Group 2 = 16 patients) of ChEIs administration on cognition with the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Frontal Assessment Battery (FAB), while depressive symptoms were measured with the Hamilton Depression Rating Scale (HDRS). After 6 months (Group 1), a significant decrease in MoCA performance was detected. After 9 months (Group 2), a significant decrease in MMSE, MoCA, and FAB performance was observed. ChEIs did not modify depressive symptoms. Overall, our data suggest MoCA is a potentially useful tool for evaluating the effectiveness of ChEIs

Accesso alla tecnologia. Access To Technologies (H.E.A.R.I.N.G. package of interventions, WHO 2021)

In Italia, lo Stato interviene con il Servizio Sanitario per l’assegnazione, agli aventi diritto, della tecnologia audiologica. La materia è regolata da una normativa specifica, spesso completata da provvedimenti regionali. Si ricorda che una normativa particolare è prevista per gli invalidi del lavoro ai quali, in caso di ipoacusia professionale, le prestazioni sono fornite dall’INAIL con procedure dedicate. Per i non aventi diritto la prescrizione medica è sempre necessaria, ma rispetto alle forniture pubbliche, non sono previste ulteriori valutazioni obbligatorie di controllo. Per le forniture pubbliche agli invalidi civili, i provvedimenti di interesse nazionale sono riportati nei Nomenclatori Tariffari del 1990 e del 1999 e nel provvedimento ad hoc sugli impianti cocleari del 2007. Oggi tutta la normativa ambulatoriale è stata sostituita dai LEA del 2017 (D.P.C.M 12 gennaio 2017) approvati, ma non ancora operativi, e che riuniscono tutti i principali argomenti in un unico documento eccetto le forniture chirurgiche. Distingueremo pertanto i LEA ambulatoriali, dai LEA chirurgici regolati da DRG. È importante sottolineare che l’atto legislativo dei LEA prevede il suo aggiornamento annuale da parte delle Societa Scientifiche, facoltà che, fino ad ora, non è mai stata esercitata

Evidence for a Chandrasekhar-mass explosion in the Ca-strong 1991bg-like type la supernova 2016hnk

Aims. We present a comprehensive dataset of optical and near-infrared photometry and spectroscopy of type Ia supernova (SN) 2016hnk, combined with integral field spectroscopy (IFS) of its host galaxy, MCG-01-06-070, and nearby environment. Our goal with this complete dataset is to understand the nature of this peculiar object. Methods. Properties of the SN local environment are characterized by means of single stellar population synthesis applied to IFS observations taken two years after the SN exploded. We performed detailed analyses of SN photometric data by studying its peculiar light and color curves. SN 2016hnk spectra were compared to other 1991bg-like SNe Ia, 2002es-like SNe Ia, and Ca-rich transients. In addition, we used abundance stratification modeling to identify the various spectral features in the early phase spectral sequence and also compared the dataset to a modified non-LTE model previously produced for the sublumnious SN 1999by. Results. SN 2016hnk is consistent with being a subluminous (MB = -16.7 mag, sBV=0.43 ± 0.03), highly reddened object. The IFS of its host galaxy reveals both a significant amount of dust at the SN location, residual star formation, and a high proportion of old stellar populations in the local environment compared to other locations in the galaxy, which favors an old progenitor for SN 2016hnk. Inspection of a nebular spectrum obtained one year after maximum contains two narrow emission lines attributed to the forbidden [Ca ii] λλ7291,7324 doublet with a Doppler shift of 700 km s-1. Based on various observational diagnostics, we argue that the progenitor of SN 2016hnk was likely a near Chandrasekhar-mass (MCh) carbon-oxygen white dwarf that produced 0.108 M of 56Ni. Our modeling suggests that the narrow [Ca ii] features observed in the nebular spectrum are associated with 48Ca from electron capture during the explosion, which is expected to occur only in white dwarfs that explode near or at the MCh limit

The lifecycle of molecular clouds in nearby star-forming disc galaxies

It remains a major challenge to derive a theory of cloud-scale (⁠≲100 pc) star formation and feedback, describing how galaxies convert gas into stars as a function of the galactic environment. Progress has been hampered by a lack of robust empirical constraints on the giant molecular cloud (GMC) lifecycle. We address this problem by systematically applying a new statistical method for measuring the evolutionary timeline of the GMC lifecycle, star formation, and feedback to a sample of nine nearby disc galaxies, observed as part of the PHANGS-ALMA survey. We measure the spatially resolved (∼100 pc) CO-to-H α flux ratio and find a universal de-correlation between molecular gas and young stars on GMC scales, allowing us to quantify the underlying evolutionary timeline. GMC lifetimes are short, typically 10−30 Myr⁠, and exhibit environmental variation, between and within galaxies. At kpc-scale molecular gas surface densities Σ_(H₂) ≥ 8 M_⊙ pc⁻²⁠, the GMC lifetime correlates with time-scales for galactic dynamical processes, whereas at Σ_(H₂) ≤ 8 M_⊙ pc⁻² GMCs decouple from galactic dynamics and live for an internal dynamical time-scale. After a long inert phase without massive star formation traced by H α (75–90 per cent of the cloud lifetime), GMCs disperse within just 1−5 Myr once massive stars emerge. The dispersal is most likely due to early stellar feedback, causing GMCs to achieve integrated star formation efficiencies of 4–10 per cent. These results show that galactic star formation is governed by cloud-scale, environmentally dependent, dynamical processes driving rapid evolutionary cycling. GMCs and H II regions are the fundamental units undergoing these lifecycles, with mean separations of 100−300 pc in star-forming discs. Future work should characterize the multiscale physics and mass flows driving these lifecycles

Star Formation Laws and Efficiencies across 80 Nearby Galaxies

We measure empirical relationships between the local star formation rate (SFR) and properties of the star-forming molecular gas on 1.5 kpc scales across 80 nearby galaxies. These relationships, commonly referred to as "star formation laws," aim at predicting the local SFR surface density from various combinations of molecular gas surface density, galactic orbital time, molecular cloud free-fall time, and the interstellar medium dynamical equilibrium pressure. Leveraging a multiwavelength database built for the PHANGS survey, we measure these quantities consistently across all galaxies and quantify systematic uncertainties stemming from choices of SFR calibrations and the CO-to-H$_2$ conversion factors. The star formation laws we examine show 0.3-0.4 dex of intrinsic scatter, among which the molecular Kennicutt-Schmidt relation shows a $\sim$10% larger scatter than the other three. The slope of this relation ranges $\beta\approx0.9{-}1.2$, implying that the molecular gas depletion time remains roughly constant across the environments probed in our sample. The other relations have shallower slopes ($\beta\approx0.6{-}1.0$), suggesting that the star formation efficiency (SFE) per orbital time, the SFE per free-fall time, and the pressure-to-SFR surface density ratio (i.e., the feedback yield) may vary systematically with local molecular gas and SFR surface densities. Last but not least, the shapes of the star formation laws depend sensitively on methodological choices. Different choices of SFR calibrations can introduce systematic uncertainties of at least 10-15% in the star formation law slopes and 0.15-0.25 dex in their normalization, while the CO-to-H$_2$ conversion factors can additionally produce uncertainties of 20-25% for the slope and 0.10-0.20 dex for the normalization.Comment: 10 pages main text + 2 appendices. ApJL in press. Data products available at https://www.canfar.net/storage/list/phangs/RELEASES/Sun_etal_2023 . Slides summarizing key results can be found at https://www.dropbox.com/s/5gsegexeo9n0t05/Sun_et_PHANGS_2023.pptx?dl=