Optical absorption spectrum in disordered semiconductor multilayers

The effects of chemical disorder on the electronic and optical properties of semiconductor alloy multilayers are studied based on the tight-binding theory and single-site coherent potential approximation. Due to the quantum confinement of the system, the electronic spectrum breaks into a set of subbands and the electronic density of states and hence the optical absorption spectrum become layer-dependent. We find that, the values of absorption depend on the alloy concentration, the strength of disorder, and the layer number. The absorption spectrum in all layers is broadened because of the influence of disorder and in the case of strong disorder regime, two optical absorption bands appear. In the process of absorption, most of the photon energy is absorbed by the interior layers of the system. The results may be useful for the development of optoelectronic nanodevices.Comment: 6 pages, 6 EPS figures, revised versio

Effect of oral genistein administration in early and late phases of allergic encephalomyelitis

Objective(s): Experimental allergic encephalomyelitis (EAE) is an autoimmune disease validated as animal model of multiple sclerosis (MS). Administration of genistein, a phytoestrogenic component of soy, to mice at the onset of EAE is known to attenuate the clinical signs of the disease. The potential effects of genistein on established EAE is less studied. In the current study, we aimed to compare the effects of genistein administration on EAE severity in early and late phases of the disease. Materials and Methods: The C57BL/6 mice were induced with EAE, using MOG 35-55 and gavaged with genistein (300 mg/kg) either after the appearance of the first clinical sign or 30 days post disease induction for ten days. 24 hr after the last gavage, mice were sacrificed. Brains and spleens were removed for assessing lymphocyte proliferation, cell cytotoxicity, and cytokine profile. Spinal cords were dissected to assess the amount of demyelination using Luxol fast blue/cresyl violet staining. Results: Administering mice with genistein, after the establishment of EAE, did not reverse the clinical signs of disease. However, treating with genistein at the onset of disease alleviated the clinical signs by reducing neuronal demyelination. Genistein suppressed the production of IFN-γ and enhanced IL-10 secretion in splenocyte and brain. Genistein also reduced IL-12 and TNF-α secretion in splenocytes, suppressed the proliferation of T-cells, and reduced the cell cytotoxicity. Conclusion: Genistein oral therapy might only reduce EAE severity if started in early phases of the disease

Terahertz and Infrared Photodetection using p-i-n Multiple-Graphene-Layer Structures

We propose to utilize multiple-graphene-layer structures with lateral p-i-n junctions for terahertz (THz) and infrared (IR) photodetection and substantiate the operation of photodetectors based on these structures. Using the developed device model, we calculate the detector dc responsivity and detectivity as functions of the number of graphene layers and geometrical parameters and show that the dc responsivity and detectivity can be fairly large, particularly, at the lower end of the THz range at room temperatures. Due to relatively high quantum efficiency and low thermogeneration rate, the photodetectors under consideration can substantially surpass other THz and IR detectors. Calculations of the detector responsivity as a function of modulation frequency of THz and IR radiation demonstrate that the proposed photodetectors are very fast and can operate at the modulation frequency of several tens of GHz.Comment: 7 pages, 4 figure

The effects of different levels of soybean meal replaced by fish meal on biochemical parameters haemolymph of freshwater crayfish (Astacus leptodactylus)

The present study examined the effects of different levels of plant protein (soybean meal) on biochemical parameters haemolymph of freshwater crayfish (Astacus leptodactylus). For this purpose, the effects of different levels of soybean meal protein including 0%, 30%, 50%, 70%, and 100% diet on some biochemical parameters and ion haemolymph of freshwater crayfish were evaluated after 60 days of trial. Sampling of 75 samples crayfish with apparently healthy haemolymph was carried out at the end of the testing period. Based on the results, with increasing soybean meal in the diet, the amount of glucose, cholesterol, triglyceride, creatinine and total protein had a significant decrease compared to the control group. A significant difference was observed in the amount of serum enzymes activities between control group and the other treatments. The amount of Bun, calcium, and sodium were not significantly different between treatments. Also, the amount of K, Fe and P in the diets containing soybean meal had a significant decrease compared with the control group

Long-Wavelength Quantum Well Infrared Photodetectors

A majority of IR sensors used for imaging arrays operating in the long-wavelength IR region between 8 µm-12 µm are based on mercury cadmium telluride (HgCdTe). This material system is unable to satisfy all the requirements imposed by modem applications. Structural difficulties due to poor uniformity, high defect densities, and weak bond strengths cause difficulties in manufacturing large IR focal plane array cameras. As an alternative, quantum well infrared photodetectors (QWIPs) utilising intersubband absorption between gallium arsenide (GaAs) wells and aluminium gallium arsenide (AIGaAs) barriers were perfected. These QWIPs possess better uniformity in comparison to HgCdTe detectors, and QWIP imaging arrays have recently become commercially available. However, the responsivity of GaAs/AlGaAs QWIPs is still lower than HgCdTe detectors. To further improve the responsivity of QWIP detectors, QWIPs with wells or barriers of GaInAsP instead of AlGaAs have been developed. Results of QWIPs made from the material systems GaAs/GaInP, GaInAs(P)/InP, (Al)GaInAs/InP, and GaInAs/AllnAs have been discussed

Conduction‐ and valence‐band offsets in GaAs/Ga0.51In0.49P single quantum wells grown by metalorganic chemical vapor deposition

We have independently estimated the conduction‐ and valence‐band offsets ΔEc and ΔEv in GaAs/Ga0.51In0.49P quantum wells by measuring the capacitance transient resulting from thermal emission of carriers from the respective wells. The heterostructure samples were grown by low‐pressure metalorganic chemical vapor deposition. The band offsets are extrapolated from the emission activation energies with appropriate corrections. The estimated values of ΔEc and ΔEv are 0.198 and 0.285 eV, respectively.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70070/2/APPLAB-56-9-833-1.pd

A New Transport Regime in the Quantum Hall Effect

This paper describes an experimental identification and characterization of a new low temperature transport regime near the quantum Hall-to-insulator transition. In this regime, a wide range of transport data are compactly described by a simple phenomenological form which, on the one hand, is inconsistent with either quantum Hall or insulating behavior and, on the other hand, is also clearly at odds with a quantum-critical, or scaling, description. We are unable to determine whether this new regime represents a clearly defined state or is a consequence of finite temperature and sample-size measurements.Comment: Revtex, 3 pages, 2 figure

Protection of mice by a λ-based therapeutic vaccine against cancer associated with human papillomavirus type 16

Objective: Human papillomavirus (HPV) oncoproteins (i.e. E6 and E7) are constitutively expressed in cervical cancer cells. The proteins are ideal targets to be used for developing therapeutic vaccines against existing HPV-associated carcinomas. To date, whole bacteriophage ('phage')-λ particles, rather than purified 'naked' DNA, have been described as highly efficient delivery vehicles for a DNA vaccine. Methods: In this study, a safe and efficient λ-based therapeutic cancer vaccine, recombinant λ-ZAP E7 phage, was developed by inserting a HPV16 E7 gene into the Lambda ZAP® cytomegalovirus vector. λ-ZAP E7 phages were employed to immunize mice against the E7-expressing murine tumor cell line (TC-1), which is used as a tumor model in an H-2b murine system. Results: The tumor-bearing mice indicated a significant inhibition of tumor growth after 3 injections of 2 × 1012 particles of recombinant phages. Released lactate dehydrogenase, interferon-γ and granzyme B from spleen cells and lymphocyte proliferation of spleen cells, which all demonstrate the enhancement of cell-mediated immunity, suggested the phages could be a potent gene delivery system in animal models. Conclusion: Our results suggest the recombinant phages can be used as effective biological tools for inducing E7-specific protective immune responses. Hence, the study introduces a possible therapeutic strategy against cervical cancer and other HPV-related neoplasia. Copyright © 2010 S. Karger AG, Basel

Recombinant λ-phage nanobioparticles for tumor therapy in mice models

Lambda phages have considerable potential as gene delivery vehicles due to their genetic tractability, low cost, safety and physical characteristics in comparison to other nanocarriers and gene porters. Little is known concerning lambda phage-mediated gene transfer and expression in mammalian hosts. We therefore performed experiments to evaluate lambda-ZAP bacteriophage-mediated gene transfer and expression in vitro. For this purpose, we constructed recombinant λ-phage nanobioparticles containing a mammalian expression cassette encoding enhanced green fluorescent protein (EGFP) and E7 gene of human papillomavirus type 16 (λ-HPV-16 E7) using Lambda ZAP- CMV XR vector. Four cell lines (COS-7, CHO, TC-1 and HEK-239) were transduced with the nanobioparticles. We also characterized the therapeutic anti-tumor effects of the recombinant λ-HPV-16 E7 phage in C57BL/6 tumor mice model as a cancer vaccine. Obtained results showed that delivery and expression of these genes in fibroblastic cells (COS-7 and CHO) are more efficient than epithelial cells (TC-1 and HEK-239) using these nanobioparticles. Despite the same phage M.O.I entry, the internalizing titers of COS-7 and CHO cells were more than TC-1 and HEK-293 cells, respectively. Mice vaccinated with λ-HPV-16 E7 are able to generate potent therapeutic antitumor effects against challenge with E7- expressing tumor cell line, TC-1 compared to group treated with the wild phage. The results demonstrated that the recombinant λ-phages, due to their capabilities in transducing mammalian cells, can also be considered in design and construction of novel and safe phage-based nanomedicines