51 research outputs found
Erythropoietin Stimulates Cancer Cell Migration and Activates RhoA Protein through a Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase-Dependent Mechanism
Full text linkInhibition of Geranylgeranyl Diphosphate Synthase Induces Apoptosis through Multiple Mechanisms and Displays Synergy with Inhibition of Other Isoprenoid Biosynthetic Enzymes
Full text linkPutative Multifunctional Signature of Lung Metastases in Dedifferentiated Chondrosarcoma
Full text linkAddition of elotuzumab to lenalidomide and dexamethasone for patients with newly diagnosed, transplantation ineligible multiple myeloma (ELOQUENT-1): an open-label, multicentre, randomised, phase 3 trial
Get PDFIsoprenoids and Cancer
No full textObjectives:
1. Global understanding of isoprenoids, their metabolism, and interface with disease.
2. Relate the clinical activity to underlying mechanisms of action(s) at the cellular and biochemical levels.
3. Know the relatively unique clinical pharmacology features associated with these agents.
4. Understand opportunities for new applications of these agents.
Presentation: 62 minute
Stereoselective Synthesis of the 5‘-Hydroxy-5‘-phosphonate Derivatives of Cytidine and Cytosine Arabinoside
No full text
Synthesis of isoprenoid bisphosphonate ethers through C–P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase
No full textA set of bisphosphonate ethers has been prepared through sequential phosphonylation and alkylation of monophosphonate ethers. After formation of the corresponding phosphonic acid salts, these compounds were tested for their ability to inhibit the enzyme geranylgeranyl diphosphate synthase (GGDPS). Five of the new compounds show IC50 values of less than 1 μM against GGDPS with little to no activity against the related enzyme farnesyl diphosphate synthase (FDPS). The most active compound displayed an IC50 value of 82 nM when assayed with GGDPS, and no activity against FDPS even at a 10 μM concentration
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