Collation of the results of the 2014 aggregate minerals survey for England and Wales

1.1 Aggregate Minerals (AM) surveys, normally undertaken at four-yearly intervals since 1973, provide an in-depth and up-to-date understanding of national and sub-national sales, inter-regional flows, transportation, consumption and permitted reserves of primary aggregates. The surveys are used to inform the development of minerals policy in respect to the production, movement and consumption of aggregates. The data are made publicly available. 1.2 This report is the collation of the data for primary aggregates for 2014, therefore there has been a five year period between this and the previous survey (AM2009). In addition to presenting information on regional and national sales, consumption, and permitted reserves of primary aggregates, the AM2014 report also presents data on the movement and consumption of primary aggregates by sub-region. Information is also presented on the quantity of aggregate minerals granted and refused planning permission and planning permission applications withdrawn between 2010 and 2014. In addition, information is presented on the quantity of aggregate minerals within planning permission applications submitted between 2010 and 2014 and were awaiting a decision at 31 December 2014. 1.3 The information is presented for England and Wales and for individual regions and was collected from aggregate producers by Mineral Planning Authorities (MPAs) using a standard form (Appendix F). It was subsequently collated at regional level by the relevant Aggregate Working Party Secretary (Appendix I) or the British Geological Survey (BGS)1 and at national level by the BGS on behalf of the Department for Communities and Local Government (DCLG) and the Welsh Government. Similar information was published by the then Department of the Environment for 1973, 1977, 1985, 1989 and 1993, the Department of the Environment, Transport and the Regions for 1997, the Office of the Deputy Prime Minister for 2001 and the Department for Communities and Local Government and the Welsh Assembly Government for 2005 and 2009 (Appendix H). Comparisons of sales, consumption and permitted reserves for these years and 2014 are provided in Tables D1 to D3

World mineral production 2007-11

This volume is the latest in the series World Mineral Production, published by the British Geological Survey. It comprises the most recent addition to a continuous dataset on global mineral production which stretches back to 1913, and includes the preceding titles World Mineral Statistics and Statistical Summary of the Minerals Industry. The data for 2011 represents the 99th year of this dataset and we have therefore decided to prepare for a “Centenary Edition” next year

Melanoma cells transfected to express CD83 induce antitumor immunity that can be increased by also engaging CD137

Interactions between CD83 and its ligand(s) can up-regulate immune responses. M2-CD83 cells, derived by transfecting the M2 clone of mouse melanoma K1735 cells to express mouse CD83, were rejected by syngeneic mice, unless they were injected with a CD83Ig fusion protein. Rejection was mediated by CD4(+) and CD8(+) T cells plus natural killer cells, whereas rejection of M2-1D8 cells, which express anti-CD137 single-chain variable region fragments (scFv), occurs in the absence of CD8(+) T cells. Furthermore, the tumor specificity of the immunity induced by the two cell lines differed. Immunization with live or mitomycin C-treated M2-CD83 cells prevented outgrowth of transplanted M2-WT cells and had therapeutic efficacy against established M2-WT tumors. A highly metastatic clone of K1735 cells, SW1-C, and its subline SW1-P2, which expresses an activating transcription factor 2-driven peptide, were then studied because they have particularly low immunogenicity. Neither SW1-C nor SW1-P2 cells became rejectable after expression of CD83 or anti-CD137 scFv. However, outgrowth of cells from either line was delayed in mice immunized against M2-CD83 or M2-1D8 cells, and immunization with a mixture of mitomycin C-treated cells from M2-CD83 plus M2-1D8 prevented tumor formation by SW1-P2 cells in five of five and by SW1-C cells in three of five mice. We conclude that M2 cells expressing CD83 can induce a tumor-destructive immune response also against SW1 cells and that this response can be made more effective by combining them with M2 cells expressing anti-CD137 scFv. A similar approach may be therapeutically beneficial against certain human cancers

Oxygen consumption during digestion in Anodonta anatina and Unio pictorum in response to algal concentration

Abstract The metabolic activity of unionid mussels influences the oxygen fluxes and other physical and chemical characteristics in aquatic systems. Unionid oxygen consumption rate during digestion and its dependency on food availability is understudied. In laboratory conditions, we quantified the oxygen consumption rate of Anodonta anatina and Unio pictorum in response to algal concentration—0.05, 6.0 and 12.0 mg of Ash Free Dry Mass of Chlorella vulgaris L-1 —and mussel dry soft-tissue mass at 19 ± 1C. Following a 5-h feeding-period, the oxygen consumption rate (mg O2 h-1 ) increased with algal concentration and mussel dry mass in both species during a 2-h digestion-period. The mean oxygen consumption per gram of dry mass (mg O2 gDM-1 h-1 ) increased with the algal concentration in both species. The oxygen consumption rate of A. anatina was significantly greater than that of U. pictorum at a given algal concentration. The A. anatina oxygen consumption per gram of dry mass decreased with increasing dry mass. Oxygen consumption rate during digestion shows inter-specific differences and is dependent on food availability. The findings inform the species specific quantification of oxygen consumption, and validation is required in in situ conditions.This work was funded by an ESRC PhD studentshi