Role of Omeprazole as An Antifungal Agent

The antifungal activity of various concentrations of omeprazole (0.1mg/ml, 0.25mg/ml, 0.5mg/ml, 1mg/ml, 2.5mg/ml, 5mg/ml, 10mg/ml, and 20mg/ml) were studied in different pH media (5 and 7) against Aspergillus niger, and Trichophyton urbrum.The laboratory results showed the inhibitory effect of omeprazole against Aspergillus niger at pH 7 and starting from concentration 10mg/ml, and against Trichophyton urbrum starting from 1mg/ml. While its antifungal activity in a medium with pH 5 was extended to reach the lower concentrations 0.25mg/ml against selected fungi. Accordingly, omeprazole is pH dependent.It seems that omeprazole changed cell membrane potential of selected fungal species which led to depolarization of cell membrane as a result of inhibition of the proton pump mechanism. This made the fungal cell not willing to uptake chemicals needed for living.Keywords: omeprazole, proton pump inhibitor, antifungal agent, Aspergillus niger, and Trichophyton urbrum

ANTIBACTERIAL ACTIVITY OF APRICOT KERNEL EXTRACT CONTAINING AMYGDALIN

Abstract Amygdalin was extracted from apricot kernels, the chemical characteristics of amygdalin are: white, crystalline, and inodorous powder, slightly soluble in cold water, very soluble in hot water, alcohol and acetone, and insoluble in ether. It has a pH of 7 in saturated aqueous solution. Amygdalin purity in the extract was estimated to give 99.5%. Amygdalin was identified in the extract by FT-IR. The sensitivity of some species of pathogenic bacteria included Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, and Streptococcus pyogenes to different concentration of amygdalin (2%, 4%, 6%, 8%, and 10%) was tested to find out the role of amygdalin as antibacterial agent. The experimental results of bacterial sensitivity to different concentrations of amygdalin, showed sensitivity of tested bacteria to all concentrations of amygdalin except concentration 2% amygdalin, bacterial species were resistant to it