Yahoo! Movies User Ratings and Descriptive Content Information, v.1.0

A fundamental aspect of rating based systems is the observation process; the process which users choose the movies they rate. Finding user to user similarity is a fundamental component for collaborative filtering. In user to user similarity ratings assigned by two users to a set of items are pairwise compared and averaged is called correlation. In this project I want to show user to user similarity adaptive i.e., we dynamically change the computation depending on the profiles of the compared users and the target movie whose prediction is sought. I evaluate the proposed theory with k-means clustering by grouping similar users which rated similar movies with same rating. i.e., whoever is having same will come under one group

Miniaturizing High Throughput Droplet Assays For Ultrasensitive Molecular Detection On A Portable Platform

Digital droplet assays – in which biological samples are compartmentalized into millions of femtoliter-volume droplets and interrogated individually – have generated enormous enthusiasm for their ability to detect biomarkers with single-molecule sensitivity. These assays have untapped potential for point-of-care diagnostics but are mainly confined to laboratory settings due to the instrumentation necessary to serially generate, control, and measure millions of compartments. To address this challenge, we developed an optofluidic platform that miniaturizes digital assays into a mobile format by parallelizing their operation. This technology has three key innovations: 1. the integration and parallel operation of hundred droplet generators onto a single chip that operates \u3e100x faster than a single droplet generator. 2. the fluorescence detection of droplets at \u3e100x faster than conventional in-flow detection using time-domain encoded mobile-phone imaging, and 3. the integration of on-chip delay lines and sample processing to allow serum-to-answer device operation. By using this time-domain modulation with cloud computing, we overcome the low framerate of digital imaging, and achieve throughputs of one million droplets per second. To demonstrate the power of this approach, we performed a duplex digital enzyme-linked immunosorbent assay (ELISA) in serum to show a 1000x improvement over standard ELISA and matching that of the existing laboratory-based gold standard digital ELISA system. This work has broad potential for ultrasensitive, highly multiplexed detection, in a mobile format. Building on our initial demonstration, we explored the following: (i) we demonstrated that the platform can be extended to \u3e100x multiplexing by using time-domain encoded light sources to detect color-coded beads that each correspond to a unique assay, (ii) we demonstrated that the platform can be extended to the detection of nucleic acid by implementing polymerase chain reaction, and (iii) we demonstrated that sensitivity can be improved with a nanoparticle-enhanced ELISA. Clinical applications can be expanded to measure numerous biomarkers simultaneously such as surface markers, proteins, and nucleic acids. Ultimately, by building a robust device, suitable for low-cost implementation with ultrasensitive capabilities, this platform can be used as a tool to quantify numerous medical conditions and help physicians choose optimal treatment strategies to enable personalized medicine in a cost-effective manner

A case of formic acid poisoning: prompting for a different line of management

Formic acid is an easily available substance and can thus be consumed voluntarily or accidentally. Here is a case who presented to our center 5 days post accidental ingestion of formic acid. He had developed acute renal failure requiring hemodialysis. Post admission he had altered sensorium probably alcohol withdrawal and later aspiration pneumonia and ARDS. He developed a late onset GI bleed on day 8 of ingestion with significant hemoglobin drop. An emergency endoscopy was done which showed a normal esophagus but extensive corrosive damage and active bleeding from gastric area. He continued to have drop in hemoglobin in-spite of aggressive volume and blood product transfusions. He was taken up for an emergency subtotal gastrectomy and viable tissue was demarcated with intraoperative endoscopy and a subtotal gastrectomy was performed. He stabilized initially but worsened again 2 days later with worsening lactic acidosis and succumbed to his illness. The fact that esophagus was completely spared with extensive involvement of stomach could possibly indicate a need for review of initial management of corrosive/organic acid poisoning

Iwasawa theory for Rankin-Selberg convolution at an Eisenstein prime

Let $p$ be an odd prime, $f$ be a $p$-ordinary newform of weight $k$ and $h$ be a normalized cuspidal $p$-ordinary Hecke eigenform of weight $l < k$. In this article, we study the $p$-adic $L$-function and $p^{\infty}$-Selmer group of the Rankin-Selberg product of $f$ and $h$ under the assumption that $p$ is an Eisenstein prime for $h$ i.e. the residual Galois representation of $h$ at $p$ is reducible. We show that the $p$-adic $L$-function and the characteristic ideal of the $p^\infty$-Selmer group of the Rankin-Selberg product of $f, h$ generate the same ideal modulo $p$ in the Iwasawa algebra i.e. the Rankin-Selberg Iwasawa main conjecture for $f \otimes h$ holds mod $p$. As an application to our results, we explicitly describe a few examples where the above congruence holds.Comment: Updated version relaxes certain assumptions and addresses typos. 35 pages. Comments are welcom

COVID-19 lockdown induced fractures

Tough times and tough measures taken by central government of India. India is under national lockdown due to COVID-19 pandemic.It was difficult for common man in many ways to deal with lockdown. The basics of life food, fuel, transport was handicapped during lockdown phase. People in major cities and towns have sources of food availability in terms of continuous grocery supply from supermarket chains, food delivery chains. It was rural population of India that was more effected due to lockdown rather than urban population.The rural population of India sustained on food that was available in around houses and in the fields. Most of them went to fields and bought vegetables for their lunch and dinner. During this process people climbed trees and fell down causing major limb injuries. We present few scenarios of injury that occurred during lockdown of COVID-19 pandemic causing major limb fractures. Tough times and tough measures to control pandemic COVID-19 caused new problems for people in search of food and daily needs. These are some of those injuries which were able to document in these tough times

Self-Healing Ability of High-Strength Fibre-Reinforced Concrete with Fly Ash and Crystalline Admixture

The aim of this study is to analyse the self-healing capability of high-strength fibre-reinforced concrete (M70) with fly ash and crystalline admixture (CA) in four types of environmental exposures i.e. Water Immersion (WI), Wet-Dry Cycles (WD), Water contact (WC) and Air Exposure (AE). Specimens for four mixes are cast, one mix containing 1.1% of CA and three mixes with 10%, 20% and 30% partial replacement of cement with fly ash and additions of 1.1% CA. The specimens were pre-cracked at 28 days, in the range of 0.10-0.40 mm and the time set for healing was 42 days. The result shows that all the mixes have considerable amount of closing ability and strength-regaining capability for all exposure conditions. The concrete with 20% fly ash and 1.1% CA has complete crack closing ability and 100% strength-regaining capability for WI and WD cycle conditions. From SEM analysis, it is confirmed that self-healing products are CaCO3 and C-S-H gel

Study Of Multi Layered Composite Shell With Shape Memory Alloy

The use of special composite materials has been continuously growing in recent years. Although many applications for composite materials include identified. general research is still being carried out in order to expand this field. New materials and advancements have been explored. One such new application is the coordination of shape memory materials inside composite materials.   In this study certain parts of the dynamic conduct of a multilayered composite shell with shape memory combination wires have been examined. The influence of SMA wires, the orientation and the thickness to diameter ratio and different boundary conditions, on changes in critical load, the natural frequencies and modes of vibration of the shell have been studied and discussed in the present study. The results presented are obtained by the use of finite element method. The analysis both static and modal has been carried out using ANSYS 12.0. The shape memory alloys possess the inherent ability to change their material properties in particularly their young’s modulus, damping capacity as well as great capacity for the generation of large internal forces. Integrating SMA’s within composite material structures potentially allow the active control of certain static and dynamic behaviour of the integrated structures