Surgical repair of indirect inguinal hernia in bonnet macaque (Macaca radiata)

Background: Hernia is a protrusion of an organ from the wall of the cavity bearing it. Omentum, adipose tissue, and intestinal loops are the most frequently involved organs. The present case report is a rare case of indirect inguinal hernia having omentum engaged in scrotum through hernial ring in a bonnet macaque (Macaca radiata) and its surgical management.Case Description: A 19-year-old male bonnet macaque was presented with distension of the right inguinal and scrotal region. Physical examination revealed an inguinal hernia. Surgical intervention was deemed necessary considering the state of the animal. The herniation was surgically corrected by the removal of the protruded fatty mass. The monkey was kept in strict confinement till complete healing. The animal recovered uneventfully in 2 weeks without any postoperative complications. This case report details a successful surgical repair of an indirect inguinal hernia in a bonnet macaque.Conclusion: Based on the present case study, it is concluded that surgery can be an ideal and effective option for the treatment of inguinal hernias in primates

CRP 2020 Reviews:Rice Agri-Food Systems (RICE)

In 2020 the CGIAR CAS Secretariat is conducting independent reviews of the 12 CGIAR Research Programs (CRPs), including this one of RICE. The reviews will provide information on quality of science and effectiveness in each CRP. This review covers the Phase II years of 2017 through 2019, with a view to identifying lessons for future research modalities

Analysis of pollen in honey samples in the district of Prayagraj, India

The analysis of pollen grains found in honey, known as melissopalynology, reveals pertinent details about the pollen and nectar sources in a location where bees produce honey, allowing researchers to identify the honey’s geographical and botanical origins. To determine the significant source plants in the area, the present analysis is conducted on five samples of winter honey that were collected from Prayagraj’s urban localities (Dahi, Baksi, Sirsa, Soraon, and Phoolpur). The methodology recommended by the International Commission of Bee Botany (ICBB) was followed in this study. Analysis of 5 honey samples recorded a diversity of 31 pollen types and one fungal spore type. The majority of pollen grains recovered from honey samples belong to entomophilous taxa (66%), 25% of the pollen is from anemophilous taxa, and 9% from amphiphilous taxa. Four honey samples (S1, S2, S3, and S5) were found to be unifloral while the remaining samples (S4) were multi-floral. The field mustard i.e. Brassica campestris L. was the predominant pollen type. The secondary frequency class contained three different pollen types, while the minor and significant minor frequency classes contained 14 and 30, respectively. With respect to the frequency of occurrence of pollen types in honey samples, field mustard was found to be a very common pollen type as they were recovered from more than 50% of the collected honey samples. The various type of pollen and spores were also observed in collected honey samples

Investigation on the Bio-degradability of the Starch Modified Polypropylene with the Help of Maleic Anhydride as a Coupling Agent

Polypropylene was modified with starch in 1/20 ratio by adding a coupling agent in the absence and presence of a compatiblizer so as to produce a modified polypropylene with the advantage of bio-degradability in lesser time as compare to normal time span of degradation. As polypropylene a hydrophobic material and starch a hydrophilic material, so maleic anhydride was used as a coupling agent and PVA used as a compatiblizer to produce proper formation of bond. For the proper inter-mixing of the polymers they were swollen by aromatic compound such as toluene at elevated temperature. The material produced was tested in IR spectroscopy, universal testing machine, water absorption test, soil burial test and scanning electron microscopy for the checking of proper inter-mixing, change in mechanical properties and to check the bio-degradability respectively

Usporedba lidokaina i kombinacije lidokaina i ketamina primijenjenih za distalnu intravensku regionalnu anesteziju (DIVRA) u goveda

The hoof diseases of cattle can be managed surgically under intravenous regional anesthesia (IVRA). For routine induction of IVRA, a tourniquet is placed circumferentially at the metacarpus/metatarsus. In the present study, hoof diseases of cattle were corrected using a modified IVRA technique. The cattle with hoof ailments were randomly divided into two groups and a tourniquet was placed just distal to the dew claws instead of at the metacarpus/metatarsus in order to decrease the dose of anesthetic. In group I lidocaine (2mg/kg) and in group II a mixture of lidocaine and ketamine (2mg/kg+1.5mg/kg) was injected into the axial digital vein to induce distal intravenous regional anesthesia (DIVRA). The heart rate, respiration rate, systolic and diastolic pressure were unaffected in both groups. Oxygen saturation was significantly (P<0.05) lower between 5 and 60 minutes in group I and between 15 and 40 minutes in group II animals. The sensory and motor block onset time was shorter, and the sensory and motor block recovery time was longer in group II animals as compared to group I animals. It was concluded that the DIVRA technique using lidocaine alone and lidocaine admixed with ketamine are suitable for hoof examination and surgery.Bolesti papaka u goveda mogu se kirurški liječiti pod intravenskom regionalnom anestezijom (IVRA). Za rutinsko uvođenje u IVRA-u postavlja se kružno čvrsti zavoj na metakarpus/metatarzus. U ovom su istraživanju bolesti papaka u goveda liječene modificiranom IVRA metodom. Istražene životinje nasumično su podijeljene u dvije skupine a zavoj kojim se samnjuje doza anestetika postavljen je, umjesto na metakarpus/metatarzus, distalno od rudimentiranih papaka. U skupini I primijenjen je lidokain (2 mg/kg), a u skupini II kombinacija lidokaina i ketamina (2 mg/kg + 1,5 mg/kg). Za uvođenje u distalnu intravensku regionalnu anesteziju (DIVRA) anestetici su aplicirani u aksijalnu digitalnu venu. Srčana frekvencija, frekvencija disanja, sistolički i dijastolički tlak u obje su skupine bili nepromijenjeni. Zasićenost kisikom bila je znakovito niža (P<0,05) između 5. i 60. minute u skupini I te između 15. i 40. minute u skupini II. Vrijeme pojave senzornih i motoričkih blokova bilo je kraće, a vrijeme oporavka tih blokova dulje u životinja u skupini II u usporedbi sa skupinom I. Zaključeno je da je DIVRA, uz upotrebu i samog lidokaina i lidokaina u kombinaciji s ketaminom, prikladna metoda za pregled i obavljanje kiruških zahvata na papcima goveda

Isolation and Characterization of Tamarind Seed Gum as Pharmaceutical Excipient

Objective: Tamarind seed gum (TSG) is a polysaccharide having galactomannans as chemical constituents, and it is extracted from the seeds of Tamarindus indica L (Family Fabaceae). Generally, polysaccharides play most important roles as thickening, gelling, emulsifying, hydrating, and suspending agents in pharmaceutical formulations. The purpose of this work was to investigate the film coating potential of tamarind seed gum (TSG), using paracetamol as a model drug. Material and Method: Tamarind seed gum, Paracetamol tablet, Hydroxypropylmethylcellulose Sodium alginate, and Distilled water. Core tablets of paracetamol were obtained from a pharmacy shop in the local market and the physicochemical properties such as weight, hardness, friability, and disintegration time were evaluated. Aqueous coating solution consists of 2% TSG hydroxypropylmethylcellulose (HPMC) (2% w/v), and sodium alginate (1% w/v) were prepared and used to coat the tablets by dip coating technique. The coated tablets were evaluated. Result: The coated tablets showed lower friability; increased disintegration time (14 min) as compared to the core tablet (3 min), improved hardness, and improved drug release profile. TSG film coated batches showed drug release profile up to 10 hrs and HPMC coated batches showed drug release up to 12 hrs. The results of drug release rate of TSG film is very closed to HPMC release profile. This TSG have good film formers properties. It is a promising natural, biodegradable, cheap and eco-friendly film former, particularly when masking of taste or objectionable odor in a solid dosage formulation is desired. It can be used as carrier in sustained release formulation.Conclusion: On the basis of result we can conclude that TSG has promising properties as pharmaceutical excipient. It could be used in the formulation of sustained release matrix as coating agent. &nbsp

Application of nano-curcumin as a natural antimicrobial agent against Gram-positive pathogens

Gram-positive bacteria cause various diseases from the superficial skin to deep tissue infections. The capability of causing numerous diseases is due to the production of virulence factors which are tightly regulated by the virulence genes. Various Gram-positive pathogenic bacteria e.g. Staphylococcus, Mycobacterium, and Listeria are capable of causing lethal infections in humans and animals. Conventional antibiotics, targeted antibiotics, and combinatorial drugs are used as therapeutic agents against Gram-positive pathogens. Due to intricate virulence pathway bacteria readily adopt resistance to available drugs. Therefore, there is need to develop some alternative approaches to combat these infections. Various natural extracts are effective against pathogenic bacteria with or without the available drugs. Curcumin is a natural extract of Curcuma longas rhizome, known as turmeric. Curcumin shows various biological activities such as antimicrobial, antioxidant and anti-inflammatory. It also shows strong antibacterial activity against Gram-positive and few Gram-negative bacteria. Besides all these beneficial applications, major drawbacks of curcumin are poor aqueous solubility and less bioavailability. However, drug delivery approaches including nanoformulation are developed to increase its stability in vitro and in vivo settings. The present review article focused on the translation of potential applications of curcumin in various diseases specifically caused by Gram-positive pathogens. Various methods used for the formulations of curcumin nanoparticles, combinatorial strategies with curcumin nanoparticles and their application in the prevention of infections have been discussed. The present article also discusses the future aspects of curcumin-nanoparticles and its use as an alternative therapeutic approach against pathogens

Organochlorine pesticides application, xenobiotic metabolizing gene polymorphism and incidences of cancers in India: a review

Excessive application of pesticides on crops has been noticed to gain maximum yield. It results in heavy damage to human health as well as environment. Pesticides application beyond permissible limit has detrimental effects on ecosystem. Organochlorine compounds are widely used as pest controller. These are considered as substantial environmental pollutant and carcinogens due to their extensive environmental release. There are sufficient numbers of studies that supports positive co-relation of organochlorine pesticides with cancer. To evaluate these detrimental effects on human health we have reviewed various studies and concluded the positive co-relation of organochloro compounds with cancers. In this study, the altered metabolism effects of organochlorine pesticides on cytochrome P450 enzyme have been observed