359 research outputs found

    Treatment and impact of mental disorders during pregnancy

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    Treatment and impact of mental disorders during pregnancy

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    Replication-coupled Gene Editing in Mammalian cells

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    The Impact of Breast Cancer Screening on Population Health

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    Breast cancer is an important public health problem with an estimated number of 1.38 million breast cancer cases and 458,000 deaths from the disease yearly worldwide. Randomized trials have shown that mammography screening significantly reduces breast cancer mortality. Besides the benefits in terms of lives saved, mammography screening is, however, also associated with harms, such as false-positive test results and overdiagnosis. This thesis describes the impact of breast cancer screening in the population and compares the effects to the effects of other interventions. We found that mammography screening has had a substantial impact on breast cancer mortality in the U.S. and is projected to continue to do so in the future. Screening women biennially from age 50 to 74 years leads to a favorable balance between benefits and harms. More intensive screening (either extending the age ranges or increasing the screenin

    Success Factors of Business Process Management Systems Implementation

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    In this research (critical) success factors for Business Process Management Systems implementation are identified and qualitatively validated. Furthermore a list of critical success factors is constructed. Based on the identified factors a BPMS implementation approach is suggested. Future research consists of situationally considering the success factors in relation to phases in the implementation approach

    A Situational Implementation Method for Business Process Management Systems

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    For the integrated implementation of Business Process Management and supporting information systems many methods are available. Most of these methods, however, apply a one-size fits all approach and do not take into account the specific situation of the organization in which an information system is to be implemented. These situational factors, however, strongly determine the success of any implementation project. In this paper a method is provided that establishes situational factors of and their influence on implementation methods. The provided method enables a more successful implementation project, because the project team can create a more suitable implementation method for business process management system implementation projects

    Using the Delphi Method to Identify Hospital-Specific Business Process Management Capabilities in The Netherlands

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    Business Process Management (BPM) is an important discipline for organisations that are desiring quality improvement. Many models for assessing, comparing and improving the maturity of organisational BPM are found in literature. An effective BPM Maturity Model should contain a validated set of capability areas specific to the application domain. We attempt to fill a gap by providing a model specific to the hospital industry. This paper presents the first phase in the development of such a model. For this we use the Delphi Method, a multi-round technique for collecting rich data and gaining consensus among a panel of experts. Based on the opinions provided by experts in hospitals and academia in The Netherlands, we identify relevant and domain-specific capabilities for improving BPM maturity in the Dutch hospital industry. Hospitals are characterised by complex, multidisciplinary processes. Our findings reflect that capabilities related to people and organisational culture are most important for achieving BPM maturity
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