A Potential Correlation Between the Temperature of the Pacific Ocean and Data from Google Trends May Yield a Warning Sign for the Outbreak of Zika

There has been a large number of reported cases of the occurrence of Zika in different countries in 2016 and it is necessary to develop an early warning system to initiate preventive campaigns against the disease. A potential early warning system based on the rise in ocean temperature of the Pacific Ni\~no Index is proposed. The efficacy is verified using data for the outbreak in Colombia as obtained from Google Trends.Comment: 3 pages, 2 figures, Open Acces

A Preliminary Mathematical Model for the Dynamic Transmission of Dengue, Chikungunya and Zika

Aedes aegypti is a known vector of Dengue, Chikungunya and Zika and the goal of this study is to propose the first mathematical model to describe the dynamic transmission of these three diseases. We present two preliminary models that consist of the SEIR model for the human populations and an SEI model for the vector to describe (a) the single transmission dynamics of dengue, Chikungunya or Zika, and (b) any possible coinfection between two diseases in the same population. In order to do that, we obtain an analytical solution of the system of 17 and 30 coupled differential equations for each model respectively, and later obtain the eigenvalues by analyzing the Jacobian matrix in order to begin the development of a surveillance system to prevent the spread of these three diseases.Comment: 5 pages, 2 figures, open acces

Analysis of an SEIR-SEI four-strain epidemic dengue model with primary and secondary infections

We propose an SEIR model for the populations and an SEI model for the vector to describe the transmission dynamics of a four-strain model with both primary and secondary dengue infections. In order to accomplish this, we propose and obtain an analytic solution of a system of 47 coupled differential equations. This would be the most complete epidemic model proposed to describe the dengue epidemic.Comment: 5 pages, 2 figures, 1 tabl

Can Bioinformatics Be Considered as an Experimental Biological Science?

The objective of this short report is to reconsider the subject of bioinformatics as just being a tool of experimental biological science. To do that, we introduce three examples to show how bioinformatics could be considered as an experimental science. These examples show how the development of theoretical biological models generates experimentally verifiable computer hypotheses, which necessarily must be validated by experiments in vitro or in vivo.Comment: 3 pages, Open Acces

Distributed computing applied applied to the identification of new drugs

This work emphasizes the assets of implementing the distributed computing for the intensive use in computational science devoted to the search of new medicines that could be applied in public healthy problems.Comment: 12 pages, Spanis

Phylogenetic tree calculations using the Grid with DAG job

The goal of the work is to implement molecular phylogenetic calculations using the Grid paradigm by means of the MrBayes software using Directed Acyclic Graphs (DAG) jobs. In this method, a set of jobs depends on the input or the output of other jobs. Once the runs have been successfully done, all the results can be collected by a specific Perl script inside the defined DAG job. For testing this methodology, we calculate the evolution of papillomavirus with 121 sequences.Comment: 5 pages, 2 figure

Identification of 11 potential malaria vaccine candidates using Bioinformatics

In this paper, we suggested eleven protein targets to be used as possible vaccines against Plasmodium falciparum causative agent of almost two to three million deaths per year. A comprehensive analysis of protein target have been selected from the small experimental fragment of antigen in the P. falciparum genome, all of them common to the four stages of the parasite life cycle (i.e., sporozoites, merozoites, trophozoites and gametocytes). The potential vaccine candidates should be analyzed in silico technique using various bioinformatics tools. Finally, the possible protein target according to PlasmoDB gene ID are PFC0975c, PFE0660c, PF08_0071, PF10_0084, PFI0180w, MAL13P1.56, PF14_0192, PF13_0141, PF14_0425, PF13_0322, y PF14_0598.Comment: 5 page

Identificaci\'on de nuevos medicamentos a trav\'es de m\'etodos computacionales

Resumen: El desarrollo de nuevos medicamentos es un problema complejo que carece de una soluci\'on \'unica y autom\'atica desde un punto de vista computacional, debido a la carencia de programas que permitan manejar grandes vol\'umenes de informaci\'on que est\'an distribuidos a lo largo de todo el mundo entre m\'ultiples bases de datos. Por ello se describe una metodolog\'ia que permita realizar experimentos in silico para la identificaci\'on actual de nuevos medicamentos. Abstract: The development of new drugs is a problem that nowadays has no solution in terms of computational power due to the lack of software for handling the big volume of available information; besides, these data are stored in multiple formats and are distributed all around the world. To resolve that, a development of an in silico drug design methodology.Comment: 20 pages, 4 figures, Spanish pape

Analyzing the love affair of Romeo and Juliet with modern mathematical tools

We facetiously suggest that the romance between Romeo and Juliet can be interpreted using modern terminology and include current temptations. Using this model, we consider various factors such as the time that they might spend consulting social networks, the time that they could spend alone together and along with friends as well as their tolerance of being able to waste the couple's money. The model consists of a set of differential equations which describes the relationship between them. Finally, we analyze the eigenvalues the mathematical equations in order to determine if the critical point in this model is stable or not in four different hypothetical scenarios.Comment: 4 pages, 0 figure

Challenges and characterization of a Biological system on Grid by means of the PhyloGrid application

In this work we present a new application that is being developed. PhyloGrid is able to perform large-scale phylogenetic calculations as those that have been made for estimating the phylogeny of all the sequences already stored in the public NCBI database. The further analysis has been focused on checking the origin of the HIV-1 disease by means of a huge number of sequences that sum up to 2900 taxa. Such a study has been able to be done by the implementation of a workflow in Taverna.Comment: 8 pages, 3 figures, appears in Proceedings of the First EELA-2 Conference, 200